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Department of Physiology, Development and Neuroscience

 
Read more at: AstraZeneca funded studentships

AstraZeneca funded studentships

14 October 2024

Two new AstraZeneca funded studentships, working with the Rawlins and Robinson labs at PDN, and starting Oct 2025 are now accepting applications. AstraZeneca Funded Non Clinical PhD Studentship (Fixed Term) in Ion channels and excitability in neuroendocrine cancer a collaborative project jointly supervised by Prof Hugh...


Read more at: Marmoset Trophoblast Stem Cells Model Shallow Embryo Implantation
Image of a marmoset embryo implanting into the uterus. The embryo (blue, central) expands to fill out the cavity and establishes only superficial contact with the uterus (green)

Marmoset Trophoblast Stem Cells Model Shallow Embryo Implantation

25 September 2024

PDN scientists have developed a pioneering method to culture marmoset placental cells in the lab, offering new insights into embryo implantation. Unlike human embryos, which implant deeply into the uterus, marmoset embryos undergo a much shallower implantation. This research opens new avenues for understanding the...


Read more at: Mother’s gut microbiome during pregnancy shapes baby’s brain development

Mother’s gut microbiome during pregnancy shapes baby’s brain development

21 August 2024

A study in mice has found that the bacteria Bifidobacterium breve in the mother’s gut during pregnancy supports healthy brain development in the fetus. Researchers from the Centre for Trophoblast Research, PDN, have compared the development of the fetal brain in mice whose mothers had no bacteria in their gut, to those...


Read more at: Multiple faces of anxiety: a frontal lobe perspective

Multiple faces of anxiety: a frontal lobe perspective

21 August 2024

A review written recently by senior postdoctoral scientist, Kevin G. Mulvihill and Professor Angela Roberts in PDN will be published in Trends in Neurosciences by Cell Press. Their review provides a novel perspective on understanding the multiple faces of anxiety, with a focus on the highly varied functions of the frontal...


Read more at: Kisspeptin signaling in astrocytes modulates the reproductive axis

Kisspeptin signaling in astrocytes modulates the reproductive axis

9 August 2024

A new paper shows that astrocyte cells in the brain influence and modify the reproductive axis. Previously, it was thought that only neurons did this. The paper, Kisspeptin signaling in astrocytes modulates the reproductive axis , is published in Journal of Clinical Investigation, and co-authored by members of the Colledge...


Read more at: PDN Professors elected to the EMBO

PDN Professors elected to the EMBO

12 July 2024

Congratulations to Professor Kathy Niakan and Professor Emma Rawlins as they are elected as Members of the European Molecular Biology Organisation (EMBO), in its 60th anniversary year. Joining 120 scientists, elected from across Europe, the Membership celebrates research excellence and outstanding achievements in life...


Read more at: Department promotions

Department promotions

17 June 2024

It is with great pleasure that we announce this years’ academic promotions in PDN. In the research and teaching track, Emma Rawlins has been promoted to Professor of Developmental Physiology, Milka Sarris and Hannah Clarke have been promoted to Professors. For teaching and scholarship, Cecilia Brasset has been promoted to...


Read more at: Professor Christine Holt awarded CBE
Professor Christine Holt

Professor Christine Holt awarded CBE

17 June 2024

It is with great pleasure that we congratulate Professor Emerita of Developmental Neuroscience, Christine Holt, who has been recognised in the King’s Birthday Honours 2024. Christine has received a CBE in recognition of her pioneering and innovative contributions to neuroscience. Professor Holt is best known for her work...


Read more at: New research from Sanson Lab

New research from Sanson Lab

7 June 2024

The extension of the ectoderm in gastrulating fruit fly embryos is remarkably robust to a pull in the perpendicular direction caused by the invagination of the neighbouring mesoderm. Embryonic development is both fascinating and visually dramatic. As the embryo takes shape, cells generate forces and tissues undergo...


Read more at: Mechanical stress combines with planar polarised patterning during metaphase to orient embryonic epithelial cell divisions
Control of the orientation of planar division in a Drosophila embryonic epithelium

Mechanical stress combines with planar polarised patterning during metaphase to orient embryonic epithelial cell divisions

28 May 2024

A new paper titled “ Mechanical stress combines with planar polarised patterning during metaphase to orient embryonic epithelial cell divisions ” has been published in Development from Guy Blanchard , Elena Scarpa , Leila Muresan and Bénédicte Sanson . A large body of work supports the Hertwig Rule, which states that the...