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Department of Physiology, Development and Neuroscience

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DDIEM: drug database for inborn errors of metabolism

A new paper published in the rare disease Orphanet Journal by the Schofield group announces the release of a new database for metabolic diseases

DDIEM: drug database for inborn errors of metabolism - Read More…

Autophagy-mediated apoptosis eliminates chromosomally abnormal cells from the mouse epiblast

New paper in Nature Communications by the Zernicka-Goetz group shows that apoptosis and autophagy ensure aneuploid cells in early stage embryos do not proceed through post-implantation development of the fetus

Autophagy-mediated apoptosis eliminates chromosomally abnormal cells from the mouse epiblast - Read More…

High doses of ketamine can temporarily switch off the brain

High doses of ketamine can temporarily switch off the brain

The Morton lab has identified two brain phenomena that may explain some of the side-effects of ketamine. Measurements of the brain waves of sheep sedated by the drug may explain the out-of-body experience and state of complete oblivion it can cause

High doses of ketamine can temporarily switch off the brain - Read More…

Chicken embryo studies hatch clue on improving life-saving therapy for preterm babies

Chicken embryo studies hatch clue on improving life-saving therapy for preterm babies

Research by the Giussani Lab published in The FASEB Journal suggests that combining currently used glucocorticoids with antioxidant could improve clinical treatment in pregnancies at risk of preterm birth

Chicken embryo studies hatch clue on improving life-saving therapy for preterm babies - Read More…

Neutrophils self-organise during the initiation of inflammatory responses

Neutrophils self-organise during the initiation of inflammatory responses

New study by the Sarris lab in Current Biology describes how close communication of neutrophils inside clusters organises their migration to sites of tissue damage and contributes to local defence

Neutrophils self-organise during the initiation of inflammatory responses - Read More…

Living cells adapt their stiffness to that of their surroundings, or not?

Living cells adapt their stiffness to that of their surroundings, or not?

New study by the Franze lab published in Nature Materials could have disproven a central dogma of mechanobiology: that living cells adapt their stiffness to the stiffness of their microenvironment.

Living cells adapt their stiffness to that of their surroundings, or not? - Read More…

Basement membrane remodelling regulates development

Basement membrane remodelling regulates development

New study by Zernicka-Goetz lab published on Nature on the mechanism of membrane perforation during the development of the mouse embryo

Basement membrane remodelling regulates development - Read More…

Cancerous cells hijack their microenvironment through long-range Notch activation

Cancerous cells hijack their microenvironment through long-range Notch activation

The Bray lab investigates how cancerous epithelial cells sustain tumor growth in their latest paper published on Current Biology, showing that epithelial cytonemes provide Delta to co-opt the normal mesenchyme through long-range Notch activation

Cancerous cells hijack their microenvironment through long-range Notch activation - Read More…

Parental exposure to pathogens can result in increased response in their offspring

Nick Burton has just published a new studio on Nature Communications about how the response in parents to environmental stress, such as infections, can prime their offspring to better react to the same type of stress.

Parental exposure to pathogens can result in increased response in their offspring - Read More…

Fat fetuses: thyroid hormone deficiency before birth modifies adipose tissue development

Fat fetuses: thyroid hormone deficiency before birth modifies adipose tissue development

New study by PDN and collaborators demonstrates that thyroid hormone deficiency before birth causes overgrowth of white adipose tissue

Fat fetuses: thyroid hormone deficiency before birth modifies adipose tissue development - Read More…

Study reveals novel aspects of the human metabolic response to hypoxia

Study reveals novel aspects of the human metabolic response to hypoxia

In a report published in the New England Journal of Medicine, Dr Andrew Murray and Dr Katie O’Brien of PDN, along with an international team of collaborators, describe new aspects of the human metabolic response to low oxygen levels

Study reveals novel aspects of the human metabolic response to hypoxia - Read More…

Cancer prediction through artificial neural network algorithms

Cancer prediction through artificial neural network algorithms

International team of researchers led by Paul Schofield developes a new algorithmic method capable of analyzing molecular data collected in studies and identifying genetic patterns associated to the development of cancer

Cancer prediction through artificial neural network algorithms - Read More…

New study by Ewa Paluch's lab makes cover of Developmental Cell

New study by Ewa Paluch's lab makes cover of Developmental Cell

The researchers used proteomics to identify key factors controlling actin organisation in mitosis

New study by Ewa Paluch's lab makes cover of Developmental Cell - Read More…

Common technique used in IVF impacts placenta growth and function

Common technique used in IVF impacts placenta growth and function

New mouse study by the Watson group published in Reproduction shows that a common technique required for in vitro fertilization changes how genes are expressed in the placenta and alters fetal and placental growth with potential implications on life-long health.

Common technique used in IVF impacts placenta growth and function - Read More…

PDN students win prizes for best oral presentation at Anatomical Meetings

The British Association of Clinical Anatomists has awarded prizes to Tabbie Brough and Katie James, while Claudia Santoni has been awarded by the Anatomical Society

PDN students win prizes for best oral presentation at Anatomical Meetings - Read More…

Evidence for an effect of receptor density on ligand occupancy and agonist EC50

In this study in Scientific Reports Gavin Jarvis and co-author Andrew Thompson reveal an unexpected effect on the relationship between drug concentration and effect

Evidence for an effect of receptor density on ligand occupancy and agonist EC50 - Read More…

Cell corners essential for correct development of cell shapes

Cell corners essential for correct development of cell shapes

New study by the Sanson group published in PLoS Biology shows that cell corners are important for normal morphogenesis in epithelia

Cell corners essential for correct development of cell shapes - Read More…

Research in sheep suggests possible early test for fetal heart health

Research in sheep suggests possible early test for fetal heart health

New study led by Dino Giussani shows that changes in heart rate due to hypoxia in advaced pregnancies could be used to predict the future heart health of babies

Research in sheep suggests possible early test for fetal heart health - Read More…

Placenta changes could mean male offspring of older mums more likely to develop heart problems in later life

Placenta changes could mean male offspring of older mums more likely to develop heart problems in later life

Changes occur in the placenta in older pregnant mothers leading to a greater likelihood of poor health in their male offspring, a study in rats by CTR has shown

Placenta changes could mean male offspring of older mums more likely to develop heart problems in later life - Read More…

Dr Paul Schofield awarded Alan Turing Fellowship

Dr Paul Schofield awarded Alan Turing Fellowship

Schofield's work in machine learning has been recognized by the national institute for data science and artificial intelligence

Dr Paul Schofield awarded Alan Turing Fellowship - Read More…

PDN unveils new departmental logo

The new logo was chosen as the winner of an internal competition among its staff

PDN unveils new departmental logo - Read More…

How synapse formation drives brain cancer growth

How synapse formation drives brain cancer growth

A study just published in Nature, by a team including Hugh Robinson of PDN, has shed new light on how glutamate receptor ion channels are involved in metastasis of cancer to the brain, showing that cancer cells which express growth-promoting glutamate receptors integrate themselves into neuronal synapses to obtain activating glutamate.

How synapse formation drives brain cancer growth - Read More…

Potential therapeutic target for early-onset preeclampsia

Potential therapeutic target for early-onset preeclampsia

Research by CTR in collaboration with Andrew Murray identified a protein response pathway during preeclampsia which could provide a new insight for potential therapeutic target of the disease

Potential therapeutic target for early-onset preeclampsia - Read More…

Margherita Turco receives ERC starting grant award

Margherita Turco receives ERC starting grant award

The CTR researchers is among 8 Cambridge recipients of European Union awards given to early-career researchers from over 50 countries

Margherita Turco receives ERC starting grant award - Read More…

Exercise in pregnancy improves health of obese mothers by restoring their tissues

Exercise in pregnancy improves health of obese mothers by restoring their tissues

Exercise immediately prior to and during pregnancy restores key tissues in the body, making them better able to manage blood sugar levels and lowering the risk of long term health problems, suggests new research carried out in mice by CTR

Exercise in pregnancy improves health of obese mothers by restoring their tissues - Read More…