How flat sheets of cells become tubular organs
New research by Guy Blanchard in collaboration with the LMB Cell Biology Division gives new insight into how flat layers of cell tissue develop into 3D structures
Rapid Cue-Specific Remodeling of the Nascent Axonal Proteome
The Holt lab at PDN has developed a new method to identify newly synthesized axonal proteins in response to axon guidance cues. Axons stimulated by different guidance cues show distinct and common signatures.
PDN scientists generate key life event in artificial mouse ‘embryo’ created from stem cells
The creation of artificial embryos has moved a step forward after an international team lead by Magda Zernicka-Goetz used mouse stem cells to produce artificial embryo-like structures capable of ‘gastrulation’, a key step in the life of any embryo
Discovery of genetic variant could lead to personalised treatments for mood disorder
New work by PDN member Andrea Santagelo on serotonine transporter gene could identify targets for tailored therapies
CTR funded PhD student awarded prize for best medical engineering project
Romina Plitman, former PhD at CTR, received the Depuy Best Postgraduate Medical Engineering Project award
Amanda Sferruzzi-Perri awarded Lister Prize Fellowship
The Lister Institute provides research funding to outstanding early career scientists whose work shows excellent potential to make an impact in the field of biomedical sciences
Five members of Dino Giussani's group awarded prizes at international meeting
Postdocs, PhDs and undergraduate members of Dino's group receive awards at the Society for Reproductive Investigation 65th Annual International Meeting
Prof Ewa Paluch awarded EMBO membership
PDN's Director of Research among 62 newly selected member of European research organization
Wolfram Schultz awarded The 2018 Gruber Neuroscience Prize
The PDN neuroscientist received the joint award for his work on the structure, organization and functions of the basal ganglia
The game of fate: tracing the origin of heterogeneity and symmetry breaking in the early mammalian embryo
New paper on Nature Communications by Magda Zernicka Goetz in collaboration with researchers from the University of Nevada digs into one of the central questions of developmental biology, single cell differentiation
How muscle satellite-like cells remain undifferentiated
New study by Hadi Boukhatmi and Sarah Bray shows population of adult satellite-like cells in Drosophila maintained through a switch in RNA-isoforms
Transcription factor HIF2a necessary for the development and function of the carotid body.
Study by Randall Johnson's lab uses genetic and physiological analysis to demonstrate the essential role of the transcription factor HIF-2alpha in the sympathetic nervous system control of the ventilatory response to hypoxia
Mechanism behind neuron death in motor neurone disease and frontotemporal dementia discovered
Scientists from Christine Holt lab in collaboration with the University of Toronto have identified the molecular mechanism that leads to the death of neurons in amyotrophic lateral sclerosis (also known as ALS or motor neurone disease) and a common form of frontotemporal dementia.
‘Sleeping’ stem cells could aid regenerative medicine for brain repair
Scientists at the Wellcome Trust/ Cancer Research UK Gurdon Institute, University of Cambridge, have identified a new type of stem cell in the brain which they say has a high potential for repair following brain injury or disease.
New studies describe role of glutamate receptor ion channels in cancer progression
Two studies published in Open Biology and Cancer Cell, co-authored by Hugh Robinson, have shed new light on how glutamate receptor ion channels are involved in cancer progression
Study shows how muscles regulate their oxygen consumption
A new study by Randall Johnson published in Cell Metabolism shows that an enzyme called FIH determines how muscles consume oxygen. Without the enzyme, the need for oxygen increases during physical exercise. The finding is of potential significance to elite athletes, who have been found to have higher levels of FIH in their muscles than others.
Azim Surani to receive coveted Canada Gairdner International Award for discovery of genomic imprinting
Azim Surani of the Gurdon Institute and Davor Solter of the Max Planck Institute of Immunobiology and Epigenetics will receive Canada's top research award from the Gairdner Foundation in recognition of their work establishing the field of epigenetics with the discovery of genomic imprinting
The world's highest lab is uncovering the secrets of extreme fitness
Andrew Murray, part of the Xtreme Everest project, was interviewed by Wired Magazine on the difficulties of testing Sherpas in high altitude, low oxygen environments
How does the brain’s spatial map change when we change the shape of the room?
Study published in Science by Juljia Kupric examines the role of “metric” cells in the GPS of the brain
Dr Matt Mason awarded 2018 Pilkington Prize
The Pilkington Prize award acknowledges excellence in teaching at the University of Cambridge
How the brain tidies up memories during sleep
Connections between brain cells are refined during sleep in a way that makes a memory stand out without interfering with previously stored memories, new study by Ole Paulsen's group shows
The body in miniature - organoid research at Meritxell Huch's lab
Dr Laura Broutier from Huch's lab interviewed about recent advancements in organoids on the latest issue of Research Horizons
PDN scientists discover the secrets behind the cuttlefish’s 3D ‘invisibility cloak’
An international team of scientists led by Trevor Wardill has identified the neural circuits that enable cuttlefish to change their appearance in just the blink to eye – and discovered that this is similar to the neural circuit that controls iridescence in squids.
The honeycomb maze provides a novel test to study hippocampal-dependent spatial navigation
A powerful new tool for the study of spatial memory was today described in Nature as a significant improvement over the standard, the Morris Water Maze. The study was led by the Sainsbury Wellcome Centre in collaboration with PDN's Julija Krupic
Female sexual behavior in mice is controlled by kisspeptin neurons
An international research team which included Prof Bill Colledge has made a major advancement in understanding how the brain controls sexual behaviour, published in Nature Communications.
Meritxell Huch awarded WICB Medal
Dr Meritxell has received the 2018 Women in Cell Biology Early Career Medal from the British Society for Cell Biology
OCD film wins Openness Award for depiction of animal research at Cambridge
A series of films illustrating how research using animals is helping further our understanding of obsessive compulsive disorder (OCD) was awarded the 2017 Openness Award in the category of Website or Use of New Media
Scientists at PDN shed light on the mechanisms of early pregnancy loss
Using a newly developed technique to culture mouse and human embryos in vitro beyond implantation, PDN researchers led by Magdalena Zernicka-Goetz show how alteration of the first morphological transformation can lead to pregnancy termination
Dino Giussani given 2017 Nick Hales Award
Prof Giussani has received the prize from the International Society for Developmental Origins of Health & Disease
Harder for T cells to fight cancer in absence of VEGF-A
New research by Randall Johnson about the role of VEGF-A in helping T-cells in low oxygen environments makes the cover of Cancer Cell