Ventromedial prefrontal area 14 provides opposing regulation of threat and reward-elicited responses in the common marmoset
New study published in the Proceedings of the National Academy of Sciences this week shows how overactivity of an area in the frontal lobes, called area 14, that shows altered activity in depression, can flatten anticipatory excitement in marmoset monkeys and cause an acute state of anxiety-like behaviour.
Insight into development of cells in the nose that can promote nerve repair
Study by the Baker lab identifies novel markers for developing olfactory ensheathing cells and unexpected parallels with oligodendrocytes
Prevention of heart disease can start before birth
Mitochondrial therapy in complicated pregnancies lowers the chance of cardiovascular problems in the offspring
Developmental potential of aneuploid human embryos cultured beyond implantation
The first detailed analysis of post-implantation development of aneuploid human embryos have been published in Nature Communications by the Zernicka-Goetz lab
Origin and function of the yolk sac in primate embryogenesis
Why do human embryos need a yolk sac and how does it form? This Perspective on Nature Communications by Thorsten Boroviak and Connor Ross explores the development and function of the yolk sac in primate embryogenesis
Kristian Franze receives Senior Academic Promotion to Professor
Kristian to become Professor of Neuronal Mechanics
DDIEM: drug database for inborn errors of metabolism
A new paper published in the rare disease Orphanet Journal by the Schofield group announces the release of a new database for metabolic diseases
Autophagy-mediated apoptosis eliminates chromosomally abnormal cells from the mouse epiblast
New paper in Nature Communications by the Zernicka-Goetz group shows that apoptosis and autophagy ensure aneuploid cells in early stage embryos do not proceed through post-implantation development of the fetus
High doses of ketamine can temporarily switch off the brain
The Morton lab has identified two brain phenomena that may explain some of the side-effects of ketamine. Measurements of the brain waves of sheep sedated by the drug may explain the out-of-body experience and state of complete oblivion it can cause
Chicken embryo studies hatch clue on improving life-saving therapy for preterm babies
Research by the Giussani Lab published in The FASEB Journal suggests that combining currently used glucocorticoids with antioxidant could improve clinical treatment in pregnancies at risk of preterm birth
Neutrophils self-organise during the initiation of inflammatory responses
New study by the Sarris lab in Current Biology describes how close communication of neutrophils inside clusters organises their migration to sites of tissue damage and contributes to local defence
Living cells adapt their stiffness to that of their surroundings, or not?
New study by the Franze lab published in Nature Materials could have disproven a central dogma of mechanobiology: that living cells adapt their stiffness to the stiffness of their microenvironment.
Trait anxiety mediated by amygdala serotonin transporter in the common marmoset
New research by the Angela Robert's lab was published in the Journal of Neuroscience
Basement membrane remodelling regulates development
New study by Zernicka-Goetz lab published on Nature on the mechanism of membrane perforation during the development of the mouse embryo
Double-label immunohistochemistry to assess labyrinth structure of the mouse placenta with stereology
The study was published by the Sferruzzi-Perri lab on the journal Placenta
Cancerous cells hijack their microenvironment through long-range Notch activation
The Bray lab investigates how cancerous epithelial cells sustain tumor growth in their latest paper published on Current Biology, showing that epithelial cytonemes provide Delta to co-opt the normal mesenchyme through long-range Notch activation
Parental exposure to pathogens can result in increased response in their offspring
Nick Burton has just published a new studio on Nature Communications about how the response in parents to environmental stress, such as infections, can prime their offspring to better react to the same type of stress.
Fat fetuses: thyroid hormone deficiency before birth modifies adipose tissue development
New study by PDN and collaborators demonstrates that thyroid hormone deficiency before birth causes overgrowth of white adipose tissue
Study reveals novel aspects of the human metabolic response to hypoxia
In a report published in the New England Journal of Medicine, Dr Andrew Murray and Dr Katie O’Brien of PDN, along with an international team of collaborators, describe new aspects of the human metabolic response to low oxygen levels
Cancer prediction through artificial neural network algorithms
International team of researchers led by Paul Schofield developes a new algorithmic method capable of analyzing molecular data collected in studies and identifying genetic patterns associated to the development of cancer
New study by Ewa Paluch's lab makes cover of Developmental Cell
The researchers used proteomics to identify key factors controlling actin organisation in mitosis
Common technique used in IVF impacts placenta growth and function
New mouse study by the Watson group published in Reproduction shows that a common technique required for in vitro fertilization changes how genes are expressed in the placenta and alters fetal and placental growth with potential implications on life-long health.
PDN students win prizes for best oral presentation at Anatomical Meetings
The British Association of Clinical Anatomists has awarded prizes to Tabbie Brough and Katie James, while Claudia Santoni has been awarded by the Anatomical Society
Evidence for an effect of receptor density on ligand occupancy and agonist EC50
In this study in Scientific Reports Gavin Jarvis and co-author Andrew Thompson reveal an unexpected effect on the relationship between drug concentration and effect
Cell corners essential for correct development of cell shapes
New study by the Sanson group published in PLoS Biology shows that cell corners are important for normal morphogenesis in epithelia
Research in sheep suggests possible early test for fetal heart health
New study led by Dino Giussani shows that changes in heart rate due to hypoxia in advaced pregnancies could be used to predict the future heart health of babies
Placenta changes could mean male offspring of older mums more likely to develop heart problems in later life
Changes occur in the placenta in older pregnant mothers leading to a greater likelihood of poor health in their male offspring, a study in rats by CTR has shown
Dr Paul Schofield awarded Alan Turing Fellowship
Schofield's work in machine learning has been recognized by the national institute for data science and artificial intelligence