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Department of Physiology, Development and Neuroscience

 
Read more at: Motion in mole-rats – new paper by Matt Mason
Picture of a naked mole-rat with an image of semi-circular canals

Motion in mole-rats – new paper by Matt Mason

3 February 2023

Working with Ewan Smith from Pharmacology and a team from Belgium, Matt Mason has been investigating how the anatomy of the semi-circular canals links to function in different mammals. The semi-circular canals are involved in the detection of head rotations and can be used to determine aspects of head orientation. The team...


Read more at: New research published by Giussani/Kane

New research published by Giussani/Kane

3 February 2023

dino_giussani_and_andrew_kane_590x488.jpg Combined steroid and statin treatment could reduce ‘accelerated ageing’ in preterm babies, study in rats suggests A new study into new-born rats, which are naturally born prematurely, has combined glucocorticoid steroids and statin therapy. The results, published today in...


Read more at: New paper explores the role of DNA methylation in placental development
Immunofluorescence image of a mouse E12.5 placenta.  The red and green fluorescence stain for the two layers of syncytiotrophoblast within the placental labyrinth – the primary site for nutrient exchange between mother and foetus

New paper explores the role of DNA methylation in placental development

24 January 2023

DNA methylation is a repressive epigenetic modification that is essential for development, exemplified by the embryonic and perinatal lethality observed in mice lacking de novo DNA methyltransferases (DNMTs). A new paper characterises the role for DNMT3A, 3B and 3L in gene regulation and development of the mouse placenta...


Read more at: New studies from the Surani Lab

New studies from the Surani Lab

23 January 2023

Two new studies have been published by the Surani lab . The first, led by Wolfram Gruhn, has discovered that epigenetic resetting in the human germline is associated with profound changes in repressive histone modifications. Gruhn et al. find that the loss of repressive epigenetic information in the early human germline...


Read more at: New mechanical boundaries paper from the Sanson lab
Sanson lab research image

New mechanical boundaries paper from the Sanson lab

3 November 2022

In a new paper, the Sanson lab demonstrates that tartan , a LRR cell surface receptor, is responsible for the formation of mechanical boundaries during axis extension following gastrulation. Differential expression of the receptor at compartmental boundaries promotes the enrichment of the actomyosin cytoskeleton, which in...


Read more at: UPDATE - Lecture Prize Award for Ewa Paluch Today
DGZ awards poster

UPDATE - Lecture Prize Award for Ewa Paluch Today

1 November 2022

Ewa receives her prize today - please join her at the online zoom awards ceremony 11.30 GMT, 12.30 German time Zoom ID: 821 3525 1351 Passcode: Awards_22 https://twitter.com/DGZ_info/status/1587072882781425666 Just announced: the German Society for Cell Biology's Carl Zeiss Lecture Prize from is to be awarded to Ewa on...


Read more at: Christine Holt awarded the Rosenstiel Award
Photo of christine holt

Christine Holt awarded the Rosenstiel Award

26 October 2022

Congratulations to Professor Christine Holt on being awarded the Lewis S. Rosenstiel Award for Distinguished Work in Basic Medical Research https://www.brandeis.edu/rosenstiel/rosenstiel-award/


Read more at: Hearing in Hedgehogs: new paper from Matt Mason
Image of hedgehog inner ear

Hearing in Hedgehogs: new paper from Matt Mason

25 October 2022

Working with the well-known Heffner group from the University of Toledo, Matt Mason has been investigating how ear structure in African pygmy hedgehogs relates to their audiogram and other aspects of hearing. Features of the middle ear apparatus which are sometimes considered primitive, found not just in hedgehogs but in a...


Read more at: New Kolahgar Lab Paper
Research Image from Kolahgar Lab

New Kolahgar Lab Paper

25 October 2022

New study: The Kolahgar lab shows a subset of intestinal precursor cells is able to sense mechanical forces at cell-cell junctions to control the production of specialised cells. More information here: https://elifesciences.org/digests/72836/forcing-gut-cells-to-maturity .


Read more at: New Microtubules Paper from Franze Lab
Expansion microscopy image of D. melanogaster neuron.

New Microtubules Paper from Franze Lab

12 October 2022

In this paper, we identify a new mechanism contributing to sorting microtubules in neuronal axons, and we integrate this mechanism with previously identified ones to explain why almost all microtubules in axons point in the same direction, this way enabling efficient long-range transport required for normal neuronal...