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FlyBase

Research interests

FlyBase is a database of genetic, genomic and functional data for Drosophila species, with a focus on the model organism Drosophila melanogaster. We integrate information from the research literature and various external databases and projects, and make these data available to the research community via our public website. In so doing, FlyBase provides an essential bioinformatic resource to the genetics, genomics and biomedical research communities all over the world.

The FlyBase project is a collaboration between four groups based at Harvard University, USA (PI Norbert Perrimon); Indiana University, USA (PIs Thom Kaufman and Brian Calvi); The University of New Mexico, USA (PIs Maggie Werner-Washburne and Richard Cripps); and The University of Cambridge, UK (PI Nick Brown).

The primary task of the FlyBase-Cambridge division is to identify genetic data from scientific articles concerning Drosophila and to record these data in a systematic manner. Relevant data include all genetic entities (genes, alleles, transgenic constructs, etc.) and certain types of associated information such as phenotypes, genetic interactions, gene product functions and models of human disease. Curated data are subsequently integrated into the FlyBase database and website.

Other responsibilities of FlyBase-Cambridge include the maintenance of the FlyBase bibliography and the development of controlled vocabularies (ontologies) used in literature curation.

Enquiries regarding FlyBase-Cambridge should be sent to the Group Manager, Steven Marygold. General enquires and feedback about FlyBase should be communicated using the Contact FlyBase form.

Key publications

Thurmond J, Goodman JL, Strelets VB, Attrill H, Gramates LS, Marygold SJ, Matthews BB, Millburn M, Antonazzo G, Trovisco V, Kaufman TC, Calvi BR and the FlyBase Consortium. (2019) FlyBase 2.0: the next generation. Nucleic Acids Res. gky1003

Rey AJ, Attrill H, Marygold SJ; the FlyBase Consortium. (2018) Using FlyBase to Find Functionally Related Drosophila Genes. Eukaryotic Genomic Databases: Methods and Protocols (M. Kollmar, ed.) pp. 493-512. Springer, New York (PMC5996772)

Howe DG, Blake JA, Bradford YM, Bult CJ, Calvi BR, Engel SR, Kadin JA, Kaufman TC, Kishore R, Laulederkind SJF, Lewis SE, Moxon SAT, Richardson JE and Smith C. (2018) Model organism data evolving in support of translational medicine. Lab Anim (NY) 47:277-289

Marygold SJ, Crosby MA, Goodman JL and The FlyBase Consortium. (2016)
Using FlyBase, a Database of Drosophila Genes and Genomes.
Drosophila: Methods and Protocols, Second ed., vol. 1478 (C. Dahmann, ed.) pp. 1-31. Springer, New York

Contact details

Group Leader: Professor Nick Brown
Email: nb117@cam.ac.uk
Tel: +44 (0)1223 334128

Group Manager: Dr Steven Marygold
Email: sjm41@cam.ac.uk
Tel: +44 (0)1223 333170

Senior Curator: Dr Gillian Millburn
Email: gm119@cam.ac.uk
Tel: +44(0)1223 333865

Group members