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Department of Physiology, Development and Neuroscience


Research interests

FlyBase is a database of genetic, genomic and functional data for Drosophila species, with a focus on the model organism Drosophila melanogaster. We integrate information from the research literature and various external databases and projects, and make these data available to the research community via our public website. In so doing, FlyBase provides an essential bioinformatic resource to the genetics, genomics and biomedical research communities all over the world.

The FlyBase project is a collaboration between four groups based at Harvard University, USA (PI Norbert Perrimon); Indiana University, USA (PIs Thom Kaufman and Brian Calvi); The University of New Mexico, USA (PI Richard Cripps); and The University of Cambridge, UK (PI Nick Brown).

The primary task of the FlyBase-Cambridge division is to identify genetic data from scientific articles concerning Drosophila and to record these data in a systematic manner. Relevant data include all genetic entities (genes, alleles, transgenic constructs, etc.) and certain types of associated information such as phenotypes, genetic interactions and gene product functions. Curated data are subsequently integrated into the FlyBase database and website.

Other responsibilities of FlyBase-Cambridge include the maintenance of the FlyBase bibliography and the development of controlled vocabularies (ontologies) used in literature curation.

Enquiries regarding FlyBase-Cambridge should be sent to the Group Manager, Steven Marygold. General enquires and feedback about FlyBase should be communicated using the Contact FlyBase form.

Key publications

Larkin A, Marygold SJ, Antonazzo G, Attrill H, dos Santos G, Garapati PV, Goodman JL, Gramates LS, Millburn G, Strelets VB, Tabone CJ, Thurmond J and the FlyBase Consortium (2021) FlyBase: updates to the Drosophila melanogaster knowledge base. Nucleic Acids Res. 49(D1) D899–D907

Antonazzo G, Urbano JM, Marygold SJ, Millburn GH and Brown NH (2020)
Building a pipeline to solicit expert knowledge from the community to aid gene summary curation.
Database 2020 baz152

The Alliance of Genome Resources Consortium (2020) Alliance of Genome Resources Portal: unified model organism research platform. Nucleic Acids Res 48(D1) D650–D658

Marygold SJ, Crosby MA, Goodman JL and The FlyBase Consortium. (2016) Using FlyBase, a Database of Drosophila Genes and Genomes. Drosophila: Methods and Protocols, Second ed., vol. 1478 (C. Dahmann, ed.) pp. 1-31. Springer, New York

Contact details

Group Leader: Professor Nick Brown
Tel: +44 (0)1223 334128

Group Manager: Dr Steven Marygold
Tel: +44 (0)1223 333170

Senior Curator: Dr Gillian Millburn
Tel: +44(0)1223 333865

Group members