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Sequential formation and resolution of multiple rosettes drive embryo remodelling after implantation

last modified Oct 15, 2018 04:59 PM
New study by Magda Zernicka-Goetz's lab on Nature Cell Biology examines the mechanisms of cavity formation during development for the correct formation of the embryo

Formation and fusion of luminal spaces is a central feature of embryogenesis. During mouse post-implantation embryogenesis two lumens form: one within the pluripotent embryonic compartment and another within the extra-embryonic compartment. Fusion of these lumens to form the pro-amniotic cavity is essential for embryo survival. This work reveals the morphogenetic events responsible for the unification of the embryonic and extraembryonic cavities.

Specifically, the data show that extra-cellular matrix signaling-mediated formation and polarized resolution of 3D epithelial rosettes mediates embryo remodeling and unification of cavities.

Extension and fusion of cavities have been described during development of different organs such as the pancreas and the kidneys. It is likely that the morphogenetic mechanism revealed by our study is used across different tissues for progression and fusion of cavities. Thus pro-amniotic cavity formation can provide an in vivo model to study in detail the cellular and molecular mechanisms controlling cavities extension and fusion.

This work was funded by the Welcome Trust, the European Research Council the EU Horizon 2020 Marie Sklodowska-Curie actions and by BBSRC Doctoral training studentship.

Reference: Neophytos Christodoulou, Christos Kyprianou, Antonia Weberling, Ran Wang, Guizhong Cui, Guangdum Peng, Naihe Jing, Magdalena Zernicka-Goetz, Sequential formation and resolution of multiple rosettes drive embryo remodelling after implantation, Nature Cell Biology