Unsupervised, frequent and remote: A novel platform for personalised digital phenotyping of long-term memory in humans

A short study description:

Krupic lab developed a novel hAge platform (healthy Age) for remote and unsupervised testing of long-term memory in humans, which has the potential to be used as an early digital biomarker for Alzheimer's disease (AD). The tests are based on research in rodents, showing that they are highly sensitive to impairments in entorhinal and hippocampal areas - the first regions affected by AD pathology. The hAge platform was used continuously by 191 individuals (18-81 years old) for more than eight weeks while they were engaged in their normal daily activities. In line with previous findings, we showed that long-term memory declines with longer inter-trial intervals and depends on the difficulty of the task. We also found that although mobile device-based testing solves scalability and access problems, it introduces new challenges related to unsupervised remote testing.     

Marius Bauza (1), Marino Krstulovic (2) and Julija Krupic (2)
(1) Sainsbury Wellcome Centre, University College London, London, UK.
(2) Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK

View the full paper here https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0284220