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Department of Physiology, Development and Neuroscience

Sanson lab research image

In a new paper, the Sanson lab demonstrates that tartan, a LRR cell surface receptor, is responsible for the formation of mechanical boundaries during axis extension following gastrulation. Differential expression of the receptor at compartmental boundaries promotes the enrichment of the actomyosin cytoskeleton, which in turn introduces a mechanical discontinuity in the developing tissue. These mechanical boundaries are important to keep cells segregated and ordered during morphogenesis.


The lead researcher, Tom Sharrock, was a PhD student funded by the BBSRC-DTP, and the other contributing researchers are Jenny Evans and Guy Blanchard, both funded by a Wellcome Trust Investigator Award to Bénédicte Sanson.


Find the full paper here: