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Evidence for an effect of receptor density on ligand occupancy and agonist EC50

last modified Dec 16, 2019 05:14 PM
In this study in Scientific Reports Gavin Jarvis and co-author Andrew Thompson reveal an unexpected effect on the relationship between drug concentration and effect

In this study Dr Jarvis and co-author Dr Thompson reveal an unexpected effect on the relationship between drug concentration and effect. This has implications for how cells regulate their response to serotonin (5-HT) and other neurotransmitters, and for how accurately pharmacologists measure those responses."

Reference: Evidence for an effect of receptor density on ligand occupancy and agonist EC50, Gavin E. Jarvis ,Andrew J. Thompson Scientific Reports volume 9, Article number: 19111 (2019)