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Bursting the Notch Bubble: New Insights into In Vivo Transcriptional Dynamics

last modified Aug 19, 2019 05:25 PM
Study from the Bray lab makes the cover of the journal Developmental Cell

This artistic rendering of the city map of Barcelona depicts the contrasting chaotic street layout in the Medieval Old City with the structured grid of the 19th century Eixample district. The transition between these two districts represents the shift from stochastic to stereotypic transcription brought about by enhancer priming. To learn more about how enhancers detect and respond to Notch signaling in real time in vivo see Falo-Sanjuan et al. (Cover image from a vector map produced by Ilyas Tukhtarev (© Ilyas Tukhtarev | Dreamstime.com))