Naiveversusnonnaive2.png
Pluripotency regulates mouse and human embryonic morphogenesis: cells that are in an unrestricted naive pluripotent state (marked by the expression of Nanog in yellow) fail to undergo proper morphogenesis and form the amniotic cavity (left structure). Loss of naive pluripotency (marked by the lack of Nanog expression) directs morphogenesis and amniotic cavity formation (right structure). Magenta labels Podocalyxin (luminal protein), cyan labels F-actin (cellular shapes) and blue labels nuclei.
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