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Dr Susanna Barrett Mierau D Phil, MD

Dr Susanna Barrett Mierau, D Phil, MD

Marie Skłodowska-Curie Independent Research Fellow

University Lecturer (fixed-term)

Susanna Mierau is accepting applications for PhD students.


Office Phone: +44 (0)1223 746746

Biography:

I am a neuroscientist-neurologist specialized in autism and related neurodevelopmental disorders.   I am a member of the Neuronal Oscillations Group in PDN working with Prof. Ole Paulsen.  I am starting my own research group this summer in PDN.

Research Interests

My research focuses on the fundamental rules that govern the development of synaptic and network activity in the cortex and how this process is disrupted in autism and related disorders, with the ultimate goal of developing novel therapies.

I am combining electrophysiological recordings at the synaptic and network level with optogenetic techniques to investigate the cell-type specific mechanisms underlying NMDA and AMPA receptor development, impact on circuit function and synaptic plasticity, and role in neurodevelopmental disorders in acute cortical slices and primary cortical cultures.  I am collaborating with computational groups at Cambridge and MIT to develop novel methods for analyzing the development of network activity.

Collaborators

Prof Ole Paulsen, PDN
Dr Sue Jones, PDN
Dr Guillaume Hennequin, Engineering
Dr Martin Hemberg, Wellcome Trust Sanger Institute
Anyscale Learning for All (ALFA) Group, MIT, Boston, USA

Teaching

I teach neurophysiology and neuroanatomy for undergraduates in the Natural Science and Medical and Veterinary Science Tripos. I also supervise Part II Neuroscience thesis projects for Cambridge undergraduates and graduate student rotation projects.  I have summer-time projects available for undergraduate students who are applying for the Amgen Scholars program, or other supported summer research programs.

Key Publications

Mierau SB, Patrizi A, Hensch TK, Fagiolini M, (2016), Cell-specific regulation of NMDA receptor maturation by Mecp2 in cortical circuits, Biological Psychiatry, 79(9), 746-54.  http://dx.doi.org/10.1016/j.biopsych.2015.05.018 [Epub ahead of print, 2015 June 5]

Volkmann RA, Fanger CM, Anderson DR, Sirivolu VR, Paschetto K, Gordon E, Virginio C, Gleyzes M, Buisson B, Steidl E, Mierau SB, Fagiolini M, Menniti FS, (2016), MPX-004 and MPX-007: New Pharmacological Tools to Study the Physiology of NMDA Receptors Containing the GluN2A Subunit. PLoS One, 11(2), e0148129. [PMID: 26829109]

Khurana V, Mierau SB, Dickerson BC, (2010), “Dementia” and Mez JB, Mierau SB, Dickerson BC, “Behavioral Neurology.” In D.M. Greer (Sr. Ed.), Pocket Neurology (pp. 96-104 & 115-125), Philadelphia: Lippincott, Williams & Wilkins.

Maalouf R, Mierau SB, Moore TA, Kaul A, (2009), First case report of community-acquired pneumonia due to Tsukamurella pulmonis.  Annals of Internal Medicine, 150(2), 147-8. [PMID: 19153422]

Banerjee A, Meredith RM, Rodríguez-Moreno A, Mierau SB, Auberson YP, Paulsen O, (2009), Double Dissociation of Spike Timing-Dependent Potentiation and Depression by Subunit-Preferring NMDA Receptor Antagonists in Mouse Barrel Cortex, Cerebral Cortex, 19(12), 2959-2969. [PMCID: PMC2774397]

Mierau SB, Meredith RM, Upton AL, Paulsen O, (2004), Dissociation of experience-dependent and-independent changes in excitatory synaptic transmission during development of barrel cortex, PNAS, 101, 15519-15523. [PMCID: PMC524435]