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Department of Physiology, Development and Neuroscience



The underlying mechanism of the hippocampal spatial representations and their role in navigation

Place cells, grid cells, border cells and head direction cells are the main spatial cells in the hippocampal formation and provide the basic units for the hippocampal cognitive map. However, their interrelationship and roles they play in navigation are still not well understood.

We are interested in finding the causal relationship between the spatial cells in the hippocampus and parahippocampal formation and their role in navigation. We will record from a large ensemble of neurons and selectively perturb defined interconnected hippocampal circuits while an animal is navigating in the virtual as well as real environments. We will investigate how these perturbations affect an animal's ability to find reward locations.

How do we remember and forget places and events?

How do we remember different places and which ones do we remember best (or not at all)? How do we forget them during the cognitive impairments such as Alzheimer’s disease?

We are going to answer these questions by developing new complex behavioural assays and integrate them with neural recordings and targeted neural stimulation.


Dr Marius Bauza
Prof John O’Keefe
Prof Ole Paulsen
Dr Dennis Chan
Dr Andras Lakatos
Prof Máté Lengyel
Dr Timothy O’Leary


Key publications: 

Krupic, J., Bauza, M., Burton, S. and O’Keefe, J. Local transformations of the hippocampal cognitive map. Science, in press (2018)

Wood, R.*, Bauza, M.*, Krupic, J.*, Burton, S., Delekate, A., Chan, D. and O'Keefe J. The Honeycomb Maze provides a novel test to study hippocampal-dependent spatial navigation. Nature, doi: 10.1038/nature25433 (2018)

Krupic, J., Wire together, fire apart. Science 357, 974-975 (2017)

Krupic, J., Bauza, M., Burton, S. and O'Keefe, J. Framing the grid: Effect of boundaries on grid cells and navigation. Journal of Physiology 594, 6489–6499 (2016)

Krupic, J. Brain Crystals. Science 6256, 47-48 (2015)

Poort, J., Khan, A. G., Pachitariu, M., Nemri, A., Orsolic, I., Krupic, J., Bauza, M., Sahani, M., Keller, G. B., Mrsic-Flogel, T. D. and Hofer, S. B. Learning Enhances Sensory and Multiple Nonsensory Representations in Primary Visual Cortex. Neuron 86, 1478-90 (2015)

Krupic, J.*, Bauza, M.*, Burton, S., Barry, C. and O’Keefe, J. Grid cell symmetry is shaped by environmental geometry. Nature 518, 232-35 (2015)

Krupic, J.*, Bauza, M.*, Burton, S., Lever, C. and O’Keefe, J. How environment geometry affects grid cell symmetry and what we can learn from it. Philosophical Transactions B 369, (2013)

Krupic, J., Burgess, N. and O’Keefe, J. Neural Representations of Location Composed of Spatially Periodic Bands. Science 337, 853-7 (2012)

Schultz, S. R., Kitamura, K., Post-Uiterweer, A., Krupic, J., Häusser, M. Spatial Pattern Coding of Sensory Information by Climbing Fiber-Evoked Calcium Signals in Networks of Neighboring Cerebellar Purkinje Cells. Journal of Neuroscience 29, 8005-8015 (2009)

Stabinis, A. and Krupic, J. Spatial–temporal frequency band of optical parametric amplifier. Optics Communications. 271: 564-568. (2007)

*these authors contributed equally


Other Publications

Krupic, J., Burgess, N. and O’Keefe, J. Spatially Periodic Cells Are Neither Formed From Grids Nor Poor Isolation. arXiv:1512.06248 (2015).

Poort, J., Khan, A. G., Krupic, J., Bauza, M., Mrsic-Flogel, T. D. and Hofer, S. B. Monitoring Activity in the Brain’s Visual Cortex in Virtual Reality Environments. NI case study, (2015)

Sir Henry Dale Fellow
University Lecturer
Picture of Dr Julija  Krupic

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