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Dr Jorge Lopez-Tello

Dr Jorge Lopez-Tello

Postdoctoral Newton Royal Society Fellow


Office Phone: +44 (0) 1223 333 882

Research Interests

Current Research Interest

During pregnancy, the mother must adapt metabolically to support offspring growth. Failures in maternal adaptation can result in pregnancy complications like gestational diabetes mellitus, defined as high glucose levels during pregnancy. This is worrying as gestational diabetes mellitus is associated with other pregnancy complications like preeclampsia and abnormal birthweight and predisposes the mother and her child to develop metabolic diseases, like type-2 diabetes in later life.

The placenta secretes hormones with metabolic effects. For example, placental lactogen, prolactins, progesterone and estrogen influence maternal metabolism by modulating insulin secretion by the pancreas and the response of tissues such as the liver, skeletal muscle and adipose tissue to the action of insulin. However, the precise role of placental endocrine function and how other placental derived-hormones influence maternal metabolic health is largely unknown.

Work performed in animal studies have shown that the placental expression of two reciprocally expressed imprinting genes, insulin-like growth factor-2 (Igf2) and H19 is linked to maternal metabolism and placental endocrine capacity during pregnancy. My current work as a Royal Society Fellow employs animal models to manipulate the imprinted Igf2-H19 locus to modify placental endocrine function and determine the impact on maternal metabolism during pregnancy and after delivery, as well as offspring growth, by using a variety of in vivo functional assays and cellular, histological and molecular techniques in vitro.

These studies are important for understanding the development of metabolic diseases during and after pregnancy.

Previous Research Experience

2017-18: Research Associate. University of Cambridge. I examined the impact of cell-specific deletion of PI3K signalling on feto-placental growth. Using PI3K-p110α gene targeting in mice, we found that PI3K-p110α plays distinct roles in the different compartments of the conceptus, which ultimately affect placental development, function and impact on fetal growth.

2018: Frontiers in Reproduction course, Marine Biological Laboratory, Boston, USA.

2014-17: PhD in Veterinary Medicine, Spain. I assessed whether maternal undernutrition compromises maternal metabolism, placental formation, vascularisation and blood flow and thereby contributes to fetal growth restriction. Moreover, I also evaluated the efficacy of Sildenafil Citrate as a possible therapy for pregnancy complications. 

2008-13: Bachelor Degree in Veterinary Medicine with an academic Erasmus Exchange Programme in Italy.

Current funding

Royal Society – Newton Funding

Society for Endocrinology - Early Career Grant

Key Publications

  1. Sandovici I, Georgopoulou A, Hufnagel AS, Schiefer SN, Santos F, Hoelle K, Lam BYH, YeoGSH, BurlingK, López-TelloJ, Reiterer M, Fowden AL, Burton GJ, Sferruzzi-Perri AN, Branco CM, Constância M. Fetus-derived IGF2 matches placental development to fetal demand. (Available online on Bioarchive server: doi.org/10.1101/520536)
  2. Balmas E#, Rana B#, Hamilton RS, Shreeve N, Kieckbusch J, Aye I, HawkesDA, López-Tello J, Yong H, Valenti S, Sferruzi-Perri AN, Gaccioli F, McKenzie ANJ, Francesco Colucci+. Lack of maternal group 2 innate lymphoid cells associated with fetal microcephaly and increased rate of endotoxin-induced abortion in mice. (Available online on Bioarchive server: http://biorxiv.org/cgi/content/short/348755v1)
  3. González-Bulnes A+, Parraguez VH, Berlinguer F, Barbero A, Garcia-Contreras C, López-Tello J, Pesantez-Pacheco JL, Martinez-Ros P (2020). The impact of prenatal environment on postnatal life and performance: Future perspectives for prevention and treatment. Theriogenology  (In press)
  4. Sferruzzi-Perri AN+, López-Tello J, Napso T, Yong HE (2020). Exploring the causes and consequences of maternal metabolic maladaptations during pregnancy. Placenta (In press)
  5. López-Tello J, Perez-Garcia V, KhiaraJ, KusinskiL, Cooper W, Andreani A, Grant I, Fernandez-Liger E, Hemberger M, Sandovici I, ConstanciaM, Sferruzzi-Perri AN+(2019). Fetal and trophoblast PI3Kp110α have distinct roles in regulating resource supply to the growing fetus. eLIFE (DOI: 10.7554/eLife.45282)
  6. López-Tello J+, Arias-Álvarez M, González-Bulnes A, Sferruzzi-Perri AN (2019). Rabbit models for studying intrauterine growth restriction and fetal programming. Molecular Reproduction & Development (DOI: 10.1002/mrd.23271)
  7. Lee CQE, Bailey A, López-Tello J, Sferruzi-Perri AN, OkkenhaugK, MoffettA, HembergerM, RossantJ. Inhibition of phosphatidylinositol-3-kinase signaling promotes the stem cell state of trophoblast. Stem Cells (DOI: doi.org/10.1002/stem.3052)
  8. López-Tello J,  Martínez-Jiménez MA, Herrera EA, KrauseBJ, Sferruzzi-Perri AN+ (2018). Progressive uterine artery occlusion leads to defects in placental formation that relate to fetal growth. Placenta (DOI: doi.org/10.1016/j.placenta.2018.10.003)
  9. Napso T#, Yong HE#, López-Tello J, Sferruzzi-Perri AN+ (2018). The role of placental hormones in mediating maternal adaptations to support pregnancy and lactation. Frontiers in Physiology (DOI: 10.3389/fphys.2018.01091) *Rated exceptional and recommended in F1000Prime as being of special significance in its field by F1000 (link).
  10. Ontiveros AE, Benglini CS, López-Tello J+ (2018) Skating through development. Molecular Reproduction & Development (DOI: doi.org/10.1002/mrd.23000)
  11. Arias-Álvarez M+, García-García RM, López-Tello J, Nieto K, Rebollar PG, Gutiérrez-Adán A, Lorenzo PL (2018) Alpha-tocopherol reduces oxidative stress and apoptosis during rabbit oocyte in vitro maturation. Reproduction, Fertility and Development (DOI: doi.org/10.1071/RD17525)
  12. Rodríguez M, García-García RM, Arias-Álvarez M, Millan P, Febrel N, Formoso-RaffertyN, López-Tello J, Lorenzo PL, Rebollar PG+ (2018) Improvements in the conception rate, milk composition and embryo quality of rabbit does after dietary enrichment with n-3 polyunsaturated fatty acids. Animal. (DOI: 10.1017/S1751731117003706)
  13. López-Tello J+, Arias-Álvarez M, González-Bulnes A, Rebollar PG (2017) Restricción Alimentaria en la Gestación de la Coneja – Revisión de los Últimos Hallazgos. REDVET, vol 8(04)
  14. Rodríguez M, García-GarcíaRM, Arias-ÁlvarezM, Formoso-Rafferty N, MillánP, López-Tello J, LorenzoPL, González-BulnesA, RebollarPG+ (2017) A diet supplemented with n-3 polyunsaturated fatty acids influences the metabolic and endocrine response of rabbit does and their offspring.  Journal of Animal Science (DOI: 10.2527/jas2017.1429)
  15. Decato BE, López-Tello J, Sferruzzi-Perri AN, Smith AD, Dean MD+ (2017) DNA methylation divergence and tissue specialization in the developing mouse placenta. Molecular Biology and Evolution (DOI:doi.org/10.1093/molbev/msx112)
  16. López-Tello J+, Arias-Álvarez M, Martínez-Jiménez MA, García-García RM, RodríguezM, Lorenzo PL, Bermejo-Poza R, González-Bulnes A, Rebollar PG (2016) Competition for materno-fetal resource partitioning in a rabbit model of undernourished pregnancy. Plos One (DOI:10.1371/journal.pone.0169194)
  17. Arias-Álvarez M+, García-García RM, López-Tello J, Rebollar PG, Gutiérrez-Adán A, Lorenzo PL (2016) In vivo and in vitro maturation of rabbit oocyte differently affects the gene expression profile, mitochondrial distribution, apoptosis and early embryo development. Reproduction, Fertility and Development  (DOI:10.1071/RD15553)
  18. Sferruzzi-Perri AN+, López-Tello J, Fowden A, Constancia M (2016) Maternal and fetal genomes interplay through PI3K-p110a signalling to modify placental resource allocation. Proceedings of the National Academy of Sciences (DOI:10.1073/pnas.1602012113)* Two commentary manuscript about our work in PNAS and Biol Reproduction. Also published in media press Daily Mail UK.
  19. López-Tello J+, Arias-Álvarez M, Rebollar PG (2016) Restricción alimentaria durante la gestación en conejas. ¿Existe un conflicto de intereses entre madre y feto? Boletín de cunicultura (ISSN: 1696-6074-20151215)
  20. López-Tello J, Arias-Álvarez M, Martínez-Jiménez MA, Barbero-Fernández A, García-García RM, RodríguezM, Lorenzo PL, Torres-Rovira L, Astiz S, González-Bulnes A, Rebollar PG+ (2016) The effects of sildenafil citrate on fetoplacental development and hemodynamics in a rabbit model of intrauterine growth restriction. Reproduction, Fertility and Development (DOI:10.1071/RD15330)
  21. López-Tello J, Barbero-Fernández A, González-Bulnes A, Astiz S, Rodríguez M, Formoso-RaffertyN, Arias-Álvarez M, Rebollar PG+ (2015) Characterization of early changes in fetoplacental hemodynamics in a diet-induced rabbit model of IUGR. Journal of Developmental Origins of Health and Disease  (DOI:10.1017/S2040174415001385)

 

Plain English

My research explores the regulation of resource allocation between the genetically-determined fetal drive for growth and the maternal nutrient requirements to support pregnancy.

Above: Gross histological images of mouse, guinea pig and rabbit placentas

Above: Lecithotrophy nutrition in the clear‐nosed skate (Raja eglanteria). Frontiers in Reproduction, Boston USA