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Dr Hadi Boukhatmi

I am exploring the role of Notch pathway in Drosophila muscle stem cells.
Dr Hadi Boukhatmi

Postdoc


Office Phone: +44 (0) 1223 333755

Research Interests

Muscular dystrophies are genetic disorders that cause progressive muscle weakness and disability. One cause of dystrophy is a failure of muscle stem cells, called Satellite Cells (SCs), to maintain and repair muscles. Despite intense biomedical research, much remains to be learnt about SCs function. Recent studies have revealed the existence of SCs in the insect Drosophila, which now emerges as a new genetic model to study SCs. Our project is to exploit genetic, cellular and molecular tools available in Drosophila to decipher mechanisms controlling SCs function in normal and muscle injury conditions. 

Collaborators 

Prof Sarah Bray
Dr Evanthia Zacharioudaki
Dr Kat Millen

Key Publications

Hadi Boukhatmi and Sarah Bray (2018). A population of adult satellite-like cells in Drosophila is maintained through a switch in RNA-isoforms. eLife 2018;7:e35954. https://elifesciences.org/articles/35954

Domenica Lovero, Luca Giordano, René Massimiliano Marsano, Alvaro Sanchez- Martinez, Hadi Boukhatmi, Maik Drechsler, Marta Oliva, Alexander J. Whitworth, Damiano Porcelli, Corrado Caggese (2018). Characterization of Drosophila ATPsynC mutants as a new model of mitochondrial ATP synthase disorders. PLoS ONE 13(8): e0201811. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0201811

Laetitia Bataillé, Hadi Boukhatmi, Jean-Louis Frendo and Alain Vincent (2017). Dynamics of transcriptional (re)- programming of syncytial nuclei in developing muscles. BMC Biology, 15:48. https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-017-0386-2

Hadi Boukhatmi, Christoph Schaub, Laetitia Bataillé, Ingolf Reim, Jean-Louis Frendo, Manfred Frasch, Alain Vincent, (2014), An Org-1–Tup transcriptional cascade reveals different types of alary muscles connecting internal organs in Drosophila, Development, 141, 3761-3771

Guillaume Pézeron, Kat Millen, Hadi Boukhatmi, Sarah Bray, (2014), Notch directly regulates the cell morphogenesis genes Reck, talin and trio in adult muscle progenitors, Journal of cell science, 127, 4634-4644

Hadi Boukhatmi, Jean Louis Frendo, Jonathan Enriquez, Michèle Crozatier, Laurence Dubois, Alain Vincent, (2012), Tup/Islet1 integrates time and position to specify muscle identity in Drosophila, Development, 139, 3572-3582

Jonathan Enriquez, Hadi Boukhatmi, Laurence Dubois, Anthony A Philippakis, Martha L Bulyk, Alan M Michelson, Michèle Crozatier, Alain Vincent, (2010), Multi-step control of muscle diversity by Hox proteins in the Drosophila embryo, Development, 137:457-466