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Department of Physiology, Development and Neuroscience



After obtaining a degree in Biochemistry and a Master of Science at the University Paris 6 (France), I worked as a research assistant in Alfonso Martinez-Arias’ lab, where I started learning about developmental biology. During my PhD in Jean-Paul Vincent’s lab at the MRC National Institute of Medical Research (London), I studied how embryonic epithelial cells undergo apoptosis after they lose contact with their neighbours. Further interested in signal transduction, I joined Eugenia Piddini’s lab as a postdoctoral researcher at the WT/CRUK Gurdon Institute (Cambridge) to study how differences in cellular fitness affect cell-fate decisions in tissue homeostasis. In 2017, I started my group at PDN with a Sir Henry Dale Fellowship, jointly funded by the Royal Society and the Wellcome Trust. We explore the roles of extracellular factors and adhesion proteins with regard to cell-fate decisions in the Drosophila intestine.


The intestinal epithelium constantly regenerates from stem cells, which adjust their behaviour to the changing physiological conditions the gut is exposed to. For example, stem cell proliferation rates can transiently increase to speed up regeneration after tissue loss or in response to the diet, before reverting to steady-state levels once correct tissue size is reached. This plasticity is essential for intestinal function, as lack of regeneration causes tissue atrophy whereas unrestricted stem cell proliferation promotes cancer.

The molecular mechanisms of gut maintenance and tissue differentiation resemble largely those used during development. For example, the same signalling pathways that control tissue growth during development control cell fate decisions in the adult or become misregulated in cancer.

Our aim is to identify the secreted and physical factors regulating gut plasticity. We focus on discovering extracellular molecules that instruct cells to proliferate in the gut and on investigating the crosstalk between the visceral mesoderm and the intestinal epithelium. We work with the intestine of the fruit fly Drosophila due to the ease with which it can be genetically manipulated and imaged with sophisticated microscopy, its rapid lifecycle and because it is cost-effective. Importantly, this organism shares more than 70% of its DNA with human disease genes, meaning that our basic research has the potential to uncover new insights into intestinal maintenance and degenerative diseases.


Funding: Wellcome Trust / Royal Society


Lab members:

Jerome Bohere, postdoc (Nov. 2017- )

Buffy Eldridge-Thomas, PhD student, Wellcome Trust (Oct. 2019- )

Yvswenne Liew, Part II student (2023/2024)

Yuan He, Part II student (2023/2024)


Past lab members:

Ayur Tadimalla, MPhil student (2022/2023)

Alexandre Barthelemy, exchange student (2023, Magistere Europeen de Genetique, Universite de Paris)

Sofia el-Hanafi, exchange student (2022, Magistere Europeen de Genetique, Universite de Paris)

Madeleine Frelon, exchange student (2022, AgroParisTech)

Juliette Durand, exchange student (2019, Magistere Europeen de Genetique, Universite de Paris)

Hannah Mudge, Part II student (2018/2019)

Mehmet Goksu, Part II student (2018/2019)

Beth Hindhaugh, Part II student (2017/2018)




Prof Nick Brown (PDN)


Key publications: 

Bohere J, Eldridge-Thomas B, Kolahgar G (2022), Vinculin recruitment to α-catenin halts the differentiation and maturation of enterocyte progenitors to maintain homeostasis of the Drosophila intestine. eLife 11:e72836

Kucinski I*, Dinan M*, Kolahgar G, Piddini E (2017), Chronic activation of JNK, JAK/STAT and oxidative stress signalling causes the loser cell status; (* equal contribution); Nat. Commun. Jul 26;8(1):136

Suijkerbuijk SJE, Kolahgar G, Kucinski I, Piddini E. (2016), Cell competition drives the growth of intestinal adenomas in Drosophila. Curr Biol. 2016 Feb 22;26(4):428-38

Kolahgar G, Suijkerbuijk SJE, Kucinski I, Poirier E, Mansour S, Simons BD, Piddini E. (2015) Cell competition modifies adult stem cell and tissue population dynamics in a JAK-STAT dependent manner. Dev Cell. 2015 Aug 10, 34(3):297-309

Wagstaff L*, Kolahgar G*, Piddini E, (2013), Competitive cell interactions in cancer: a cellular tug of war. Trends Cell Biol. 2013 Apr;23(4):160-7 (* equal contribution)

Vincent JP, Kolahgar G, Gagliardi M, Piddini E, (2011), Steep differences in Wingless signaling trigger Myc-independent competitive cell interactions. Dev Cell. 2011 Aug 16; 21(2):366-74

Kolahgar G*, Bardet PL*, Langton P, Alexandre C, Vincent JP, (2011), Apical deficiency triggers JNK-dependant apoptosis in the embryonic epidermis of Drosophila. Development. 2011 Jul 138(14):3021-31 (* equal contribution)

Bardet PL, Kolahgar G, Mynett A, Miguel-Aliaga I, Briscoe J, Meier P, Vincent JP, (2008), A fluorescent reporter of caspase activity for live imaging. PNAS. 2008 Sep 16;105(37):13901-5

Antoine K, Ferbus D, Kolahgar G, Prosperi MT, Goubin G, (2005), Zinc finger protein overexpressed in colon carcinoma interacts with the telomeric protein hRap1. J Cell Biochem. 2005 Jul 1;95(4):763-8

Teaching and Supervisions


NST II P6 Cell differentiation and organogenesis

Sir Henry Dale Fellow
Picture of Dr Golnar  Kolahgar

Contact Details

01223 334 129
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