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Eva K Pillai

Eva K Pillai

PhD candidate


Office Phone: +44 (0)1223 333762

Research Interests

Exploring the role of mechanics in nervous system development

Neurons in the eye extend axons across massive distances to reach their synaptic target in the brain. Most studies of this process have focused on how chemical molecules guide axon navigation accurately. Our lab has shown that local tissue stiffness in the brain also regulates the pathfinding decisions of these axons.

Hence, in my project, I am studying the interplay between these mechanical and chemical signals during visual system development.

Collaborators

Kristian Franze

Key Publications

Thompson AJ, Pillai EK, Dimov IB, Holt CE, Franze K, (2018), Simultaneous in vivo time-lapse stiffness mapping and fluorescence imaging of developing tissue, bioRxiv doi:10.1101/323501

Koser DE, Thompson AJ, Foster SK, Dwivedy A, Pillai EK, Sheridan G, Svoboda H, Viana M, Costa LF, Guck J, Holt CE, Franze K, (2016), Mechanosensing is critical for axon growth in the developing brain, Nature Neuroscience, DOI: 10.1038/nn.4394