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Department of Physiology, Development and Neuroscience



I am interested in why memories can last so long and how they are constructed by the brain. I use rodent models to assess memory and figure out what neural mechanisms lead to their persistence. I am particularly interested in the regulation of the MAPK pathway and interactions of dopamine and glutamate signalling in its regulation.


Dr Amy L Milton (Dept of Psychology)
Dr Lucy Cheke (Dept of Psychology)
Prof Bastian Hengerer (Boerhinger Ingelheim)
Dr Joanne Edgar (University of Bristol)


Key publications: 

EN Cahill, AL Milton (2019) Neurochemical and molecular mechanisms underlying the retrieval-extinction effect. Psychopharmacology, 1-22

EN Cahill, MA Wood, BJ Everitt, AL Milton (2018) The role of prediction error and memory destabilization in extinction of cued-fear within the reconsolidation window. Neuropsychopharmacology, 1

M Dos Santos, EN Cahill, G Dal Bo, P Vanhoutte, J Caboche, B Giros, N Heck "Cocaine increases dopaminergic connectivity in the nucleus accumbens". Brain Structure and Function (2018) 223 (2), 913-923

Cahill EN, Vousden GH, Exton-McGuinness MTJ, Beh IRC, Swerner CB, Macak M, Abas S, Cole CC, Kelleher BF, Everitt BJ, Milton AL “Limbic zif268 expression engaged by reactivation of a rewarded T-maze task memory is not required for stable performance.” Neuroscience (2018) 370: 112-120

Cahill E, Pascoli V, Trifilieff P, Lüscher C, Caboche J, Vanhoutte P  “D1R/GluN1 complexes in the striatum integrate dopamine and glutamate signalling to control synaptic plasticity and cocaine-induced responses.” Molecular Psychiatry, 2014, Dec; 19(12):1295-304. doi: 10.1038/mp.2014.73.

Pascoli V, Cahill E, Bellivier F, Caboche J, Vanhoutte P “Extracellular Signal-Regulated Protein Kinases 1 and 2 Activation by Addictive Drugs: A Signal Toward Pathological Adaptation.” (Review) Biological Psychiatry, 2014, Dec 15;76(12):917-26. doi: 10.1016/j.biopsych.2014.04.005.

Cahill E, Salery M, Vanhoutte P, Caboche J “Convergence of dopamine and glutamate signaling onto striatal ERK activation in response to drugs of abuse.” (Review) Frontiers in Pharmacology, 2014 Jan 8;4:172. doi: 10.3389/fphar.2013.00172.

Roze E, Cahill E, Martin E, Bonnet C, Vanhoutte P, Betuing S, Caboche J “Huntington’s disease and striatal signaling” (Review) Frontiers in Neuroanatomy, 2011, Aug 5:55. doi: 10.3389/fnana.2011.00055.

Larkin A, Fahey B, Gobbo O, Callaghan CK, Cahill E, O'Mara SM, Kelly AM “Blockade of NMDA receptors pre-training, but not post-training, impairs object displacement learning in the rat” Brain Research, 2008, Mar 14;1199:126-32. doi: 10.1016/j.brainres.2008.01.019.

Affiliated Lecturer in Neurophysiology
Picture of Dr Emma  N Cahill

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+44 (0)1223 333805
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