Research
I am interested in why memories can last so long and how they are constructed by the brain. I use rodent models to assess memory and figure out what neural mechanisms lead to their persistence. I am particularly interested in the regulation of the MAPK pathway and interactions of dopamine and glutamate signalling in its regulation.
Collaborators
Dr Amy L Milton (Dept of Psychology)
Dr Lucy Cheke (Dept of Psychology)
Prof Bastian Hengerer (Boerhinger Ingelheim)
Dr Joanne Edgar (University of Bristol)
Publications
EN Cahill, AL Milton (2019) Neurochemical and molecular mechanisms underlying the retrieval-extinction effect. Psychopharmacology, 1-22
EN Cahill, MA Wood, BJ Everitt, AL Milton (2018) The role of prediction error and memory destabilization in extinction of cued-fear within the reconsolidation window. Neuropsychopharmacology, 1
M Dos Santos, EN Cahill, G Dal Bo, P Vanhoutte, J Caboche, B Giros, N Heck "Cocaine increases dopaminergic connectivity in the nucleus accumbens". Brain Structure and Function (2018) 223 (2), 913-923
Cahill EN, Vousden GH, Exton-McGuinness MTJ, Beh IRC, Swerner CB, Macak M, Abas S, Cole CC, Kelleher BF, Everitt BJ, Milton AL “Limbic zif268 expression engaged by reactivation of a rewarded T-maze task memory is not required for stable performance.” Neuroscience (2018) 370: 112-120
Cahill E, Pascoli V, Trifilieff P, Lüscher C, Caboche J, Vanhoutte P “D1R/GluN1 complexes in the striatum integrate dopamine and glutamate signalling to control synaptic plasticity and cocaine-induced responses.” Molecular Psychiatry, 2014, Dec; 19(12):1295-304. doi: 10.1038/mp.2014.73.
Pascoli V, Cahill E, Bellivier F, Caboche J, Vanhoutte P “Extracellular Signal-Regulated Protein Kinases 1 and 2 Activation by Addictive Drugs: A Signal Toward Pathological Adaptation.” (Review) Biological Psychiatry, 2014, Dec 15;76(12):917-26. doi: 10.1016/j.biopsych.2014.04.005.
Cahill E, Salery M, Vanhoutte P, Caboche J “Convergence of dopamine and glutamate signaling onto striatal ERK activation in response to drugs of abuse.” (Review) Frontiers in Pharmacology, 2014 Jan 8;4:172. doi: 10.3389/fphar.2013.00172.
Roze E, Cahill E, Martin E, Bonnet C, Vanhoutte P, Betuing S, Caboche J “Huntington’s disease and striatal signaling” (Review) Frontiers in Neuroanatomy, 2011, Aug 5:55. doi: 10.3389/fnana.2011.00055.
Larkin A, Fahey B, Gobbo O, Callaghan CK, Cahill E, O'Mara SM, Kelly AM “Blockade of NMDA receptors pre-training, but not post-training, impairs object displacement learning in the rat” Brain Research, 2008, Mar 14;1199:126-32. doi: 10.1016/j.brainres.2008.01.019.
