Herbison Lab
We aim to understand how neural circuitry in the hypothalamus controls fertility. Our investigations focus on exploring the way in which two different kisspeptin neuron populations control the activity of the GnRH neurons to generate pulsatile and surge patterns of reproductive hormone secretion.
We use a range of methodologies extending from transcriptome analysis through to ex vivo electrophysiology and calcium imaging, and in vivo chemogenetics and GCaMP fibre photometry. Our studies are undertaken in genetically modified mice and include those representing models of common infertility disorders such as hypothalamic amenorrhea and PMOS (PCOS).
Estrogen receptors and kisspeptin neurons.
Image credit: Herbison Lab
Current Research Projects
How do the arcuate kisspeptin neurons manage to generate intermittent synchronous activity critical for their role as the GnRH pulse generator?
What are the key extrinsic and hormonal inputs to the arcuate kisspeptin neurons and how do they modulate their activity?
Members
- Professor Allan Herbison
- Dr. Paul Morris
- Dr. Szilvia Vas
- Dr. Miguel Ruiz Cruz
- Dr. Zulfiye Gul
- Ms. Tithi Gore
We are not currently accepting applications from potential PhD students
Contact
- https://x.com/HerbiLab
- aeh36[at]cam.ac.uk