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Department of Physiology, Development and Neuroscience

 

Professor of Neurobiology and Director of Studies in Medicine and Veterinary Medicine, Newnham College
Tel: +44 (0)1223 334057, Fax: +44 (0)1223 333840, E-mail: ajm41@cam.ac.uk

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Publications

2022

2021

  • Vas S, Nicol AU, Kalmar L, Miles J, Morton AJ. (2021) Abnormal patterns of sleep and EEG power distribution during non-rapid eye movement sleep in the sheep model of Huntington's disease. Neurobiology of Disease 155, 105367. doi: 10.1016/j.nbd.2021.105367.
  • Schneider WT, Vas S, Nicol AU, Morton AJ. (2021) Abnormally abrupt transitions from sleep-to- wake in Huntington's disease sheep (Ovis aries) are revealed by automated analysis of sleep/wake transition dynamics. PLoS One 16, e0251767. doi:10.1371/journal.pone.0251767.
  • Sorby-Adams AJ, Schneider WT, Goncalves RP, Knolle F, Morton AJ. (2021) Measuring executive function in sheep (Ovis aries) using visual stimuli in a semi-automated operant system. Journal of Neuroscience Methods 351, 109009. doi: 10.1016/j.jneumeth.2020.109009.
  • Ciosi M, Cumming SA, Chatzi A, Larson E, Tottey W, Lomeikaite V, Hamilton G, Wheeler VC, Pinto RM, Kwak S, Morton AJ, Monckton DG. (2021) Approaches to Sequence the HTT CAG Repeat Expansion and Quantify Repeat Length Variation. Journal of Huntington's Disease 10, 53-74. doi: 10.3233/JHD-200433.

2020

  • O'Connell AB, Kuchel TR, Perumal SR, Sherwood V, Neumann D, Finnie JW, Hemsley KM, Morton AJ. (2020) Longitudinal magnetic resonance spectroscopy and diffusion tensor imaging in sheep (Ovis aries) with quinolinic acid lesions of the striatum: Time-dependent recovery of N- acetylaspartate and fractional anisotropy. Journal of Neuropathology and Experimental Neurology 79,1084-1092. doi: 10.1093/jnen/nlaa053. PMID: 32743645
  • Nicol, A., Morton, A.J. (2020) Characteristic patterns of EEG oscillations in sheep (Ovis aries) induced by ketamine may explain the psychotropic effects seen in humans. Scientific Reports 10, 9440. doi: 10.1038/s41598-020-66023-8.
  • Schneider, W.T., Vas, S.K., Nichol, A., Morton, A.J. (2020) Characterising sleep spindles in sheep. eNeuro 7(2):ENEURO.0410-19.2020. doi: 10.1523/ENEURO.0410-19.2020.
  • Lindner, M., Gilhooley, M.J., Palumaa, T., Morton, A.J., Hughes, S. Hankina, M.W. (2020) Expression and localization of Kcne2 in the vertebrate retina. Investigative Ophthalmology and Visual Science 6, 33. doi: 10.1167/iovs.61.3.33
  • Vas, S., Casey, J.M., Schneider, W.T., Kalmar, L., Morton, A.J. (2020) Wake-Promoting and EEG Spectral Effects of Modafinil After Acute or Chronic Administration in the R6/2 Mouse Model of Huntington's Disease. Neurotherapeutics 17, 1075-1086. doi: 10.1007/s13311-020- 00849-y. PMID: 32297185; PMCID: PMC7609772

2019

  • Morton, A.J., Middleton, B., Rudiger, S., Bawden, C.S., Kuchel, T.R., and Skene, D.J. (2019) Increased plasma melatonin in presymptomatic Huntington disease sheep (Ovis aries): Compensatory neuroprotection in a neurodegenerative disease? J Pineal Res. 68, e12624
  • Ouk, K., Aungier, J., Ware, M,. and Morton, A.J. (2019) Abnormal photic entrainment to phase delaying stimuli in the R6/2 mouse model of Huntington's disease, despite retinal responsiveness to light. eNeuro 6 pii: ENEURO.0088-19.2019
  • O’Connell, A., Sinnott, B., Kuchel, T. R., Perumal, S. R., Fraser, C. K., Hemsley, K. M., and Morton, A. J. (2019) Neurological Examination of Sheep (Ovis aries) with Unilateral and Bilateral Quinolinic Acid Lesions of the Striatum Assessed by Magnetic Resonance Imaging. Journal of Neurology and Experimental Neuroscience  5 (02). https://doi.org/10.17756/jnen.2019-054
  • Knolle, F. Goncalves, R.P., Davies, E.l., Duff, A.R., Morton, A.J. (2019) Response-inhibition during problem solving in sheep. International Journal of Comparative Psychology, 32, in press
  • Morton, A.J., Skillings, E.A., Wood, N.I., Zheng, Z. (2019) Antagonistic pleiotropy in mice carrying a CAG repeat expansion in the range causing Huntington's disease. Scientific Reports 9. 37.

2018

  • McBride, S.D., Morton, A.J. (2018) Indices of comparative cognition: assessing animal models of human brain function. Experimental Brain Research 236, 3379-3390.
  • Morton, A.J. (2018) Large-Brained Animal Models of Huntington's Disease: Sheep. Methods in Molecular Biology 1780, 221-239.
  • Polyzos, A.A., Wood, N.I., Williams, P., Wipf, P., Morton, A.J., McMurray, C.T. (2018)  XJB-5-131-mediated improvement in physiology and behaviour of the R6/2 mouse model of Huntington's disease is age- and sex- dependent. PLoS One 13, e0194580.
  • Pfister, E.L., DiNardo, N., Mondo, E., Borel, F., Conroy, F., Fraser, C., Gernoux, G., Han, X., Hu, D., Johnson, E., Kennington, L., Liu, P., Reid, S.J. , Sapp, E., Vodicka, P., Kuchel, T. , Morton, A.J., Howland, D., Moser, R., Sena-Esteves M., Gao, G., Mueller, C., DiFiglia M., and Aronin, N. (2018) Artificial miRNAs reduce human mutant huntingtin throughout the striatum in a transgenic sheep model of Huntington's disease. Human Gene Therapy https://doi.org/10.1089/hum.2017.199
  • McBride, S., & Morton, A. (2018). Visual attention and cognitive performance in sheep. Applied Animal Behaviour Science, 206, 52-58.
  • Ast, A., Buntru, A., Schindler, F., Hasenkopf, R., Schulz, A., et al. (2018) mHTT Seeding Activity: A Marker of Disease Progression and Neurotoxicity in Models of Huntington's Disease. Molecular Cell 71, 675-688
  • Garland, H., Wood N.I., Skillings, E.A., Detloff, P.J., Morton, A.J. and Grant, R.A. (2018) Characterisation of progressive motor deficits in whisker movements in R6/2, Q175 and Hdh knock-in mouse models of Huntington’s disease. Journal of Neuroscience Methods 300, 103-111
  • Hook, P.W., McClymont, S.A., Cannon, G.H., Law, W.D., Morton, A.J., Goff, L.A. and McCallion, A.S. (2018) Single-cell RNA-Seq of mouse dopaminergic neurons informs candidate gene selection for sporadic Parkinson disease. The American Journal of Human Genetics 102, 427–446
  • Polyzos, A.A., Wood, N.I., Williams, P., Wipf, P., Morton, A.J. and McMurray, C.T. (2018) XJB-5-131-mediated improvement in physiology and behaviour of the R6/2 mouse model of Huntington’s disease is age- and sex-dependent. PLoS One 13, e0194580
  • Keilar, C. and Morton, A.J. (2018) Early neurodegeneration in R6/2 mice carrying the Huntington’s disease mutation with a super-expanded CAG repeat, despite normal lifespan. Journal of Huntington’s Disease 7, 76

2017

  • Knolle, F., Goncalves, R.P. and Morton, A.J. (2017) Sheep recognize familiar faces and unfamiliar human faces from two-dimensional images.  In Press Royal Society Open Science 101098/rsos.171228

  • Kantor, S., Varga, J., Kulkarni, S. and Morton, A.J. (2017) Chronic paroxetine treatment prevents the emergence of abnormal EEG oscillations in Huntington's disease mice. In Press Neurotherapeutics 10.1007/s13311-017-0546-7

  • Knolle, F., McBride, S.D., Stewart, J.E., Goncalves, R.P. and Morton, A.J. (2017) A stop-signal task for sheep: introduction and validation of a direct measure for the stop-signal reaction time. Animal Cognition 20 615–626

  • Skene, D.J., Middleton, B., Fraser, C.K., Pennings, J.L., Kuchel, T.R., Rudiger, S.R., Bawden, C.S. and Morton, A.J. (2017) Metabolic profiling of presymptomatic Huntington's disease sheep reveals novel biomarkers.  7, 43030

  • Kantor, S., Varga, J., Kulkarni, S. and Morton, A.J. (2017) Chronic paroxetine treatment prevents the emergence of abnormal EEG oscillations in Huntington’s disease mice. In Press Neurotherapeutics

  • Jacobsen, J.C., Erdin, S., Chiang, C., Hanscom, C., Handley, R.R., Barker, D.D., Stortchevoi, A., Blumenthal, I., Reid, S.J., Snell, R.G., MacDonald, M.E., Morton, A.J., Ernst, C., Gusella, J.F. and Talkowski, M.E. (2017) Potential molecular consequences of transgene integration: The R6/2 mouse example.

2016

  • Ouk, K., Aungier, J. and Morton, A.J. (2016) Prolonged day length exposure improves circadian deficits and survival in a transgenic mouse model of Huntington’s disease.Neurobiology of Sleep and Circadian rhythms , 27–38
  • Kantor, S.K., Varga, J. and Morton, A.J. (2016) A single dose of hypnotic corrects sleep and EEG abnormalities in Huntington’s disease mice. Neuropharmacology, In Press, Link
  • Kumar, A., Zhang, J., Tallaksen-Greene, S., Crowley, M.R., Crossman, D.K., Morton, A.J., van Groen, T.,  Kadish, I., Albin, R.L., Lesort, M. and Detloff, D.J. (2016) 
Allelic series of Huntington’s disease knock-in mice reveals expression discorrelates. Human Molecular Genetics 
doi: 10.1093/hmg/ddw040
  • Ouk, K., Hughes, S., Pothecary, C.A., Peirson, S.N. and Morton, A.J. (2016) Attenuated pupillary light responses and loss of opsin expression parallels decline in circadian disruption in two different mouse models of Huntington’s disease. Experimental Neurology 25, 24
  • Perentos, N., Martins, A.Q., Cumming, R., Mitchell, N.L., Palmer, D.N., Sawiak, S.J. and Morton, A.J. (2016) An EEG investigation of sleep homeostasis in healthy and CLN5 Batten disease affected sheep Journal of Neuroscience 36, 8238-8249
  • Nicol, A.U., Perentos, N., Martins, A.Q. and Morton, A.J. (2016) Automated detection and characterisation of rumination in sheep using in vivo electrophysiology. Physiology & Behavior 163, 258-266
  • Sawiak, S.J., Wood, N.I. and Morton, A.J. (2016) Similar progression of morphological and metabolic phenotype in R6/2 mice with different CAG repeats revealed by in vivo magnetic resonance imaging and spectroscopy. Neurobiology of disease 5, 271-283
  • Glynn, D., Skillings, E.A. and Morton A.J. (2016) A comparison of discrimination learning in Touchscreen and 2-choice swim tank using an allelic series of Huntington's disease mice. Journal of Neuroscience Methods 265, 56-71
  • Skillings, E.A. and Morton, A.J. (2016) Delayed onset and reduced cognitive deficits through pre-conditioning with 3-Nitropropionic acid is dependant on sex and CAG repeat length in the R6/2 mouse model of Huntington’s disease. Journal of Huntington’s Disease 5, 19-32
  • Kumar, A., Zhang, J., Tallaksen-Greene, S., Crowley, M.R., Crossman, D.K., Morton, A.J., van Groen, T., Kadish, I., Albin, R.L., Lesort, M. and Detloff, D.J. (2016) 
Allelic series of Huntington’s disease knock-in mice reveals expression discorrelates. Human Molecular Genetics Vol. 25(8) 1619-1636

2015

  • Furmston, T., Morton, A.J. and Hailes, S (2015) A significance test for inferring affiliation networks from spatio-temporal data. PlosOne 10(7) e0132417 Link
  • McBride, S.D., Perentos, N. and Morton, A.J. (2015) A mobile, high-throughput semi-automated system for testing cognition in large non-primate animal models of Huntington disease.  Journal of Neuroscience Methods doi:10.1016/2015.08.025 Link
  • Ciamei, A., Detloff, P.J. and Morton, A.J. (2015) Progression of behavioural despair in R6/2 and Hdh knock-in mouse models recapitulates depression in Huntington's disease.  Behavioural Brain Research, 291, 140-146 Link
  • Sawiak, S. and Morton, A.J. (2015) The Cambridge MRI database for animal models of Huntington disease. Neuroimage Link
  • McLennan, K. M., Skillings, E.A., Rebelo C.J.B., Corke M.J., Pires Moreira, M.A. Morton, A.J., Constantino-Casas, F. (2015) Validation of an automatic recording system to assess behavioural activity level in sheep (Ovis aries). Small Ruminant Research Link
  • Larson, E., Fyfe, I., Morton, A.J. and Monckton, D.G. (2015) Age-, tissue- and length-dependent bidirectional somatic CAG-CTG repeat instability in an allelic series of R6/2 Huntington disease mice. Neurobiology of Disease (in press) Link
  • Perentos, N., Martins, A.Q., Watson, T.C., Bartsch, U., Mitchell, N.L., Palmer, D.N., Jones, M.W. and Morton, A.J. (2015) Translational neurophysiology in sheep: measuring sleep and neurological dysfunction in CLN5 Batten disease affected sheep. Brain (in press) Link
  •  Wood, N.I. and Morton, A.J. (2015) Social behaviour is impaired in the R6/2 mouse model of Huntington’s disease. Journal of Huntington’s Disease 4 61-73
  • Sawiak, J.S.,Perumal, S.R., Rudiger, S.R., Matthews, L., Mitchell, N.l., McLaughlan, C.J., Bawden, C.S., Palmer, D.N., Kuchel, T. and Morton, A.J. (2015) Rapid and progressive regional brain atrophy in CLN6 Batten disease affected sheep measured with longitudinal magnetic resonance imaging. PlosOne 10(7) e0132331

2014

  • McBride, S.D., Perentos, N. and Morton, A.J. (2014) Understanding the concept of a reflective surface: Can sheep improve navigational ability through the use of a mirror? Animal Cognition 18 361-71 Link
  • Buonincontri, G., Wood, N.I., Puttick, S.G., Ward, A.O., Carpenter, T.A., Sawiak,S.J. and Morton, A.J. (2014) Right Ventricular Dysfunction in the R6/@ transgenic mouse model of Huntington’s disease is unmasked by dobutamine. Journal of Huntington’s Disease 1(1): 25-32 Link
  •  Morton, A.J., Rudiger, S.R., Wood, N.I., Sawiak, S.J., Brown, G.C., McLaughlan, C.J., Kuchel, T.R., Snell, R.G., Faull, R.L. and Bawden, C.S. (2014) Early and progressive circadian abnormalities in Huntington's disease sheep are unmasked by social environment. Human Molecular Genetics 23, (13): 3375-3383 Link
  • Furmston, T., Hailes, S. and Morton, A.J. (2014) A Bayesian residual-based test for cointegration. Royal Society Interface in press Link
  • Strömbom, D., Mann, R.P., Wilson, A.M., Hailes, S., Morton, A.J., Sumpter, D.J.T., and King, A.J. (2014) Solving the shepherding problem: Heuristics for herding autonomous, interacting agents.  Royal Society Interface 11 (100)  Link
  • Skillings E. A., Glynn, D. and Morton, A.J. (2014) Beneficial Effects of Environmental Enrichment and Food Entrainment in the R6/2 Mouse Model of Huntington's Disease. Brain and Behaviour 4, 675–686 Link
  • McBride, S.D., Perentos, N. and Morton, A.J. (2014) Understanding the concept of a reflective surface: Can sheep improve navigational ability through the use of a mirror? Animal Cognition DOI 10.1007/s10071-014-0807-3 Link

2013

  • Wood, N.I., McAllister, C.J., Cuesta, M., Aungier, J., Fraenkel, E. and Morton, A.J. (2013) Adaptation to experimental jet-lag in R6/2 mice despite circadian dysrhythmia. PLoS One. 8(2):e55036. Link
  • Morton, A.J. (2013) Circadian and sleep disorder in Huntington's disease. Exp Neurol. 243:34-44. Link
  • Morton, A.J. (2013) Huntington’s disease and sleep. HDBuzz Special Feature Link
  • Morton, A.J. (2013) Simple rules for a good night’s sleep in Huntington’s disease. HDBuzz Link
  • Sawiak, S.J., Wood, N.I., Williams, G.B., Morton, A.J. and Carpenter, T.A. (2013) Voxel-based morphometry with templates and validation in a mouse model of Huntington’s disease. Magnetic Resonance Imaging 31:1522-31 Link
  • Pouladi, M.A., Morton, A.J. and Hayden, M.R. (2013) Choosing an animal model for the study of Huntington's disease. Nat Rev Neurosci 14, 708-721 Link
  • Reid,S.J., Patassini, S., Handley, R.R., Rudiger, S.R., McLaughlan, C.J., Osmand, A., Jacobsen, J.C., Morton, A.J., Weiss, A., Waldvogel, H.J., MacDonald, M.E., Gusella, J.F., Bawden, C.S., Faull, R.L.M., and Snell, R.G. (2013) Further Molecular Characterisation of th OVT73 Transgenic Sheep Model of Huntington’s Disease Identifies Cortical Aggregates. Journal of Huntington’s Disease 2, 279 –295 DOI 10.3233/JHD-130067 Link
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  • Ma, L., Chen, K., Clarke, D.J., Nortcliffe, C.P., Wilson, G.G., Edwardson, J.M., Morton, A.J., Jones, A.C. and Dryden, D.T. (2013) Restriction endonuclease TseI cleaves A:A and T:T mismatches in CAG and CTG repeats. Nucleic Acids Research 41 (9): 4999-5009 Link
  • Kantor, S., Szabo, L., Varga, J., Cuesta, M. and Morton A.J. (2013) Progressive sleep and electroencephalogram changes in mice carrying the Huntington’s disease mutation. Brain 136, 2147-2158 Link
  • Morton, A.J. and Howland, D. S. (2013) Large genetic animal models of Huntington’s disease. Journal of Huntington’s Disease 2, 3-19 Link
  • Cuesta, M., Aungier, J. and Morton, A.J. (2013) Behavioral therapy reverses circadian deficits in a transgenic mouse model of Huntington’s disease. Neurobiology of Disease 63, 85-91 Link
  • Mason, A.G., Tome, S., Simard, J.P.,  Randell T. L., Bammler, T.K., Beyer, R.P., Morton, A.J., Pearson, C.E. and La Spada, A.R. (2013)  Expression levels of DNA replication and repair genes predict regional somatic repeat instability in the brain but are not altered by polyglutamine disease protein expression or age. Human Molecular Genetics 23:6 1606-1618 Link

2012

  • Cuesta, M., Aungier, J. and Morton, A.J. (2012) The methamphetamine-sensitive circadian oscillator is dysfunctional in a transgenic mouse model of Huntington's disease. Neurobiology of Disease 45, 145-55 Link
  • Kielar, C., Sawiak, S.J., Navarro Negredo, P., Tse, D.H. and Morton, A.J. (2012) Tensor-based morphometry and stereology reveal brain pathology in the Complexin1 knockout mouse PLoS ONE (in press) 7(2):e32636 Link
  • King, A.J., Wilson, A. M., Wilshin, S.D., Lowe, J., Haddadi, H., Hailes, S. and Morton, A.J. (2012) Selfish-herd behaviour of sheep under threat. Current Biology (in press) Link
  • Haddadi, H., King, A.J., Wills, A.P., Fay, D., Lowe, J., Morton, A.J., Hailes, S. and Wilson, A.M. (2012) Determining association networks in social animals; choosing spatial-temporal criteria and sampling rates. Behavioural Ecology and Sociobiology 1-10 Link
  • Wood, N.I., Sawiak, S.J., Buonincontri, G., Niu, Y., A.D, Carpenter, A. Giussani, D. A., Morton, A.J. (2012) Direct evidence of progressive cardiac dysfunction in a transgenic mouse model of Huntington’s disease. Journal of Huntington’s Disease 1 65-72 Link
  • Gong, B., Kielar,, C, Morton, A.J. (2012) Aggregation precedes ubiquitination during early inclusion formation in a transgenic mouse carrying the Huntington's disease mutation In press PLoS One Link
  • Sawiak, S.J., Wood, N.I., Carpenter, A., Morton, A.J. (2012) Huntington's disease mouse models online: high-resolution MRI images with stereotaxic templates for computational neuroanatomy. PLoS One 7, e53361 Link
  • Bulley, S.J., Cheney, J.G. and Morton, A.J. (2012) Direct visualisation of abnormal dendritic spine morphology in the hippocampus of the R6/2 transgenic mouse model of Huntington’s disease. Journal of Huntington’s Disease 1, 267-273 Link

2011

  • Morton, A.J. and Avanzo, L. (2011) Executive decision-making in the domestic sheep. PLoS ONE 6(1): e15752 Link
  • Williams, R.H, Morton, AJ and Burdakov, D. (2011) Paradoxical function of orexin/hypocretin circuits in a mouse model of Huntington's disease, Neurobiology of Disease 42,(3):438-45 Link
  • Duzdevich, D., Li, J. Whang, J., Takahashi, H., Takeyasu, K., Dryden, D.T.F., Morton, A.J. and Edwardson, J.M. (2011) Unusual Structures Are Present in DNA Fragments Containing Super-Long Huntingtin CAG Repeats. PLoS One 6(2): e17119 Link
  • Wood, N.I, Glynn. D, and Morton A.J. (2011) "Brain training" improves cognitive performance and survival in a transgenic mouse model of Huntington's disease. Neurobiology of Disease 42, 427-37 Link
  • Hobbs-Chell, H., King, A.J., Sharratt, H., Haddadi, H., Rudiger, S.R., Hailes, S., Morton, A.J. and Wilson, A.M. (2011) Data-loggers carried on a harness do not adversely affect sheep locomotion. Research in Veterinary Science 93(1):549-552 Link

2010

  • Wood, N.I., Carta, V., Milde, S., Skillings, E.A., McAllister, C.J., Ang, Y.L., Duguid, A., Wijesuriya, N., Afzal, S.M., Fernandes, J.X., Leong, T.W. and Morton A.J. (2010) Responses to environmental enrichment differ with sex and genotype in a transgenic mouse model of Huntington's disease. PLoS One. 2010 Feb 12;5(2):e9077 Link
  • Maywood, E.S., Fraenkel, E., McAllister, C.J., Wood, N.I., Reddy, A.B., Hastings, M.H. and Morton, A.J. (2010) Disruption of peripheral circadian timekeeping in a mouse model of Huntington's disease and its restoration by temporally scheduled feeding. Journal of Neuroscience 30, 10199-204 Link
  • Glynn, D., Gibson, H.E., Harte, M.K., Reim, K., Jones, S., Reynolds, G.P. and Morton, A.J. (2010) Clorgyline-mediated reversal of neurological deficits in a Complexin 2 knockout mouse. Human Molecular Genetics 19:3402-12 Link
  • Goodman, A.O., Rogers, L., Pilsworth, S., McAllister, C.J., Shneerson, J.M., Morton, A.J. and Barker, R.A (2010) Asymptomatic sleep abnormalities are a common early feature in patients with Huntington’s disease. Current Neurology and Neuroscience Reports, 11, 211-217 Link
  • Goodman, A.O., Morton, A.J. and Barker, R.A. (2010) Identifying sleep disturbances in Huntington’s disease using a simple disease-focused questionnaire. PLoS Currents 2:RRN1189 Link

2009

  • Sawiak, S.J., Wood, N.I., Williams, G.B., Morton, A.J. and Carpenter, T.A. (2009) Use of Magnetic Resonance Imaging for Anatomical Phenotyping of the R6/2 Mouse Model of Huntington's Disease. Neurobiology of Disease 33, 12-9 Link
  • Sawiak, S.J., Wood, N.I., Williams, G.B., Morton, A.J. and Carpenter, T.A. (2009) Voxel-based morphometry in the R6/2 transgenic mouse reveals differences between genotypes not seen with manual 2D morphometry. Neurobiology of Disease 33, 20-7 Link
  • Pallier, P.N., Drew, C.J. and Morton AJ. (2009) The detection and measurement of locomotor deficits in a transgenic mouse model of Huntington's disease are task- and protocol-dependent: Influence of non-motor factors on locomotor function. Brain Research Bulletin, 78, 347-355 Link
  • Morton, A.J., Glynn, D., Leavens, W., Zheng, Z., Faull, R.L.M., Skepper, J.N. and Wight, J.M (2009) Paradoxical delay in the onset of disease caused by super-long CAG repeat expansions in R6/2 mice. Neurobiology of Disease 33, 331-341 Link
  • Menalled, L., El-Khodor, B.F., Patry, M., Suárez-Fariñas, M., Orenstein, S.J., Zahasky, B., Leahy, C., Wheeler, V., Yang, X.W., MacDonald, M., Morton, A.J., Bates, G., Leeds, J., Park, L., Howland, D., Signer, E., Tobin, A. and Brunner, D. (2009) Systematic behavioral evaluation of Huntington's disease transgenic and knock-in mouse models. Neurobiology of Disease 35, 319-36 Link
  • Ciamei, A. and Morton, A.J. (2009) Progressive imbalance in the interaction between spatial and procedural memory systems in the R6/2 mouse model of Huntington's disease. Neurobiology of Learning and Memory Oct;92(3):417-28 Link

2008

  • Van der Burg, J.M.M., Bacos, K., N.I., Andreas Lindqvist, A., Wierup, N., Wamsteeker, J.I., Smith, R., Deierborg, T., Kuhar, M., Bates, G.P., Mulder, H., Erlanson-Albertsson, C., Morton, A.J., Brundin, P., Petersén, A. and Björkqvist, M. (2008) Increased metabolism in the R6/2 mouse model of Huntington’s disease. Neurobiology of Disease 29, 41-51 Link
  • Gong, B., Lim, M. C. Y., Wanderer, J., Wyttenbach, A. and Morton, A.J. (2008) Time-lapse analysis of aggregate formation in an inducible PC12 cell model of Huntington's disease reveals time-dependent aggregate formation that transiently delays cell death. Brain Research Bulletin 75,146-157 Link
  • Ciamei, A. and Morton, A.J. (2008) Rigidity in social and emotional memory in the R6/2 mouse model of Huntington's disease. Neurobiology of Learning and Memory 89, 533-44 Link
  • Wood, N.I., Goodman, A., Van der Burg, J.M.M., Gazeau, V., Brundin, P., Björkqvist, M., Petersén, A., Tabrizi, S., Barker, R.A. and Morton, A.J. (2008) Increased thirst and drinking in Huntington's disease and the R6/2 mouse. Brain Research Bulletin 76, 70-79 Link
  • Goodman, A.O.G., Murgatroyd, P.R., Medina-Gomez, G., Wood, N.I., Finer, N., Vidal-Puig,, A.J., Morton, A.J. and Barker, R.A. (2008) The metabolic profile of early Huntington's disease - a combined human and transgenic mouse study. Experimental Neurology 210, 691-8 Link
  • Michell, A.W., Goodman, A.O., Silva, A.H., Lazic, S.E., Morton, A.J. and Barker, R.A. (2008) Hand tapping: A simple, reproducible, objective marker of motor dysfunction in Huntington's disease. Journal of Neurology 255, 1145-52 Link
  • Bussey, T.J., Padain, T.L., Skillings, E.A., Winters, B.D., Morton, A.J. and Saksida, L.M. (2008) The touchscreen cognitive testing method for rodents: How to get the best out of your rat. Learning and Memory 15, 516-23 Link
  • Court, F., Gillingwater, T.H., Melrose, S., Sherman, D.L., Greenshields, K., Morton, A.J., Harris, J.B., Willison, H.J. and Ribchester R.R. (2008) Identity, developmental restriction and reactivity of extralaminar cells capping mouse neuromuscular junctions Journal of Cell Science 121, 3901-11Link
  • Wade, A., Jacobs, P., Morton, A.J. (2008) Atrophy and degeneration in sciatic nerve of presymptomatic mice carrying the Huntington's disease mutation. Brain Research, 1188, 61-68 Link

2007

  • Pallier,P.N., Maywood, E.A., Zheng, Z., Chesham, J., Inyushkin, A.N., Dyball, R., Hastings, M., Morton, A.J. (2007) Pharmacological imposition of sleep slows cognitive decline and reverses dysregulation of circadian gene expression in a transgenic mouse model of Huntington's disease. Journal of Neuroscience, 27, 7869-7878 Link 
  • Kung VW, Hassam R, Morton AJ, Jones S. (2007) Dopamine-dependent long term potentiation in the dorsal striatum is reduced in the R6/2 mouse model of Huntington's disease. Neuroscience, 146:1571-80 Link
  • Lazic, S.E., Goodman, A.O., Grote, H.E., Blakemore, C., Morton, A.J., Hannan, A.J., van Dellen, A., Barker, R.A. (2007) Olfactory abnormalities in Huntington's disease: Decreased plasticity in the primary olfactory cortex of R6/1 transgenic mice and reduced olfactory discrimination in patients. Brain Research 1151:219-26 Link
  • Morton, A. J. (2007) Ecstasy. Is the party over? The Biochemist 29 (2) 4-7 Link
  • Wanderer, J., Morton, A.J. (2007) Differential Morphology and Composition of Inclusions in the R6/2 Mouse and PC12 Cell Models of Huntington's Disease. Journal of Histochemistry and Cell Biology, 127(5):473-84 Link

2006

  • Glynn. D., Sizemore, R.J., Morton A.J. (2006) Early motor development is abnormal in complexin 1 knockout mice. Neurobiology of Disease 25(3):483-95 Link
  • Wood, N., Pallier, P.N., Wanderer, J., Morton, A. J. (2007) Systemic administration of Congo red does not improve motor or cognitive function in R6/2 mice. Neurobiology of Disease 25(2):342-53 Link
  • Phillips, W. Morton, A.J., Barker, RA (2006) Limbic neurogenesis/ plasticity in the R6/2 mouse model of Huntington's disease. Neuroreport 17, 1623-1627 Link
  • Glynn. D., Reim, K., Brose, N., Morton A.J. (2007) Depletion of Complexin II does not affect disease progression in a mouse model of Huntington's disease (HD); Support for role for complexin II in behavioural pathology in a mouse model of HD. Brain Research Bulletin 72(2-3):108-20 Link
  • Hernandez-Espinosa, D. and Morton, A.J. (2006) Calcineurin inhibitors cause an acceleration of the neurological phenotype in a mouse transgenic for the human Huntington's disease mutation. Brain Research Bulletin 69, 669-79 Link
  • Morton, A.J., Skilings, E., Bussey, T., and Saksida, L.M. (2006) Measuring cognitive deficits in disabled mice using an automated interactive touchscreen system. Nature Methods 3(10): 767 Link

2005

  • Phillips, W. Morton, A.J., Barker, RA (2005) Abnormalities of neurogenesis in the R6/2 mouse model of Huntington's disease are due to the in vivo microenvironment. Journal of Neuroscience, 25, 11586-11594 Link
  • Gibson, H.E., Reim, K., Brose, N., Morton, A.J., Jones, S. (2005) Impaired CA3 mossy fibre LTP in the R6/2 mouse model of Huntington's disease and in the complexin II knockout mouse. European Journal of Neuroscience, 22, 1701-1712 Link
  • Glynn, D., Drew, C. J., Reim, K., Brose, N. and Morton, A.J. (2005) Profound ataxia in Complexin I knockout mice masks a complex phenotype that includes exploratory and habituation deficits. Human Molecular Genetics, 16, 2369-2385 Link
  • Pallier , P.N., Zheng, Z., Morton, A.J. (2005) Pharmacological imposition of sleep prevents cognitive decline in a transgenic mouse model of Huntington's disease. Journal of Neuroscience 27, 7869-78 Link
  • Hunt, J., Morton, A.J. (2005) Atypical Diabetes Associated with Inclusion Formation in the R6/2 Mouse Model of Huntington's Disease is not improved by treatment with hypoglycemic agents. Experimental Brain Research, 166, 220-9 Link
  • Henderson, G., Morton, A.J., Little, H (2005) Drug Abuse: from gene through cell to behavior. Current Opinion in Pharmacology, 5, 1-3 Link
  • Morton, A.J. (2005) Ecstasy: pharmacology and neurotoxicity. Current Opinion in Pharmacology, 5, 79-87 Link
  • Morton, A.J., Hunt, M.J., Hodges, A.K, Lewis, P. D. Redfern, A. J. Dunnett, S. B., Jones, L. (2005) A combination drug therapy improves cognition and reverses gene expression changes in a mouse model of Huntington's disease. European Journal of Neuroscience 21,855-870 Link
  • Morton, A.J., Wood, N.I., Hastings, M. Hurelbrink, C., Barker, R.A., Maywood, E.A. (2005) Disintegration of the sleep/wake cycle and circadian timing in Huntington's disease. Journal of Neuroscience 25, 157-163 Link
  • Wasle, B., Turvey, M., Larina, O., Thorn, P., Skepper, J. Morton, A.J., Edwardson, J.M. (2005) Syncollin is required for efficient zymogen granule exocytosis. Biochemical Journal 385, 721-7 Link

2004

  • Morton, A.J. (2004) Molecular pathogenesis in Huntington's disease. Advances in Clinical Neuroscience and Rehabilitation 4 (1) 9-11 Link
  • Ribchester, R.R., Thomson, D., Wood, N.I., Hinks, T., Gillingwater, T.H., Wishart, T.M., Court, F.A., Morton, A.J. (2004) Progressive abnormalities in skeletal muscle and neuromuscular junctions of transgenic mice expressing the Huntington's disease mutation, European.Journal of Neuroscience 20, 3092-3114 Link
  • Freeman, W. and Morton, A. J. (2004) Regional and progressive changes in brain expression of complexin II in a mouse transgenic for the Huntington's Disease mutation. Brain Research Bulletin 63, 45-55 Link
  • Freeman, W. and Morton, A.J. (2004) Differential messenger RNA expression of complexins in mouse brain. Brain Research Bulletin 63, 33-44 Link

2003

  • Ma L., Carter R.J., Morton A.J. and Nicholson, L.F.B. (2003) RAGE is expressed in pyramidal cells of the hippocampus following moderate hypoxic ischemic brain injury in rats. Brain Research 966, 167-174
  • Ma, L., Morton, A.J. and Nicholson L.F.B. (2003) Microglia decrease with age in a mouse model of Huntington’s disease. Glia 43, 274-280
  • Wood, N.I. and Morton, A.J. (2003) Chronic lithium chloride treatment has variable effects on motor behaviour and survival of mice transgenic for the Huntington's disease mutation. Brain Research Bulletin 61, 375-383
  • Edwardson, J.M., Wang, C-T., Gong, B., Wyttenbach, A., Bai, J., Jackson, M.B., Chapman, E.B. and Morton A.J. (2003) Expression of mutant huntingtin blocks exocytosis in PC12 cells by depletion of complexin II. Journal of Biological Chemistry 278, 30849-53
  • Glynn, D., Bortnick, R.A. and Morton, A.J. (2003) Complexin II is essential for normal neurological function in mice. Human Molecular Genetics 19, 2431-2448

2002

  • Hickey, M.A, Reynolds, G.P. and Morton, A.J. (2002) The role of dopamine in motor symptoms in the R6/2 transgenic mouse model of Huntington’s disease. Journal of Neurochemistry 81, 46-59

2001

  • Morton, A.J and Edwardson, J.M. (2001) Progressive depletion of Complexin II in a transgenic mouse model of Huntington’s disease. Journal of Neurochemistry 76, 166-172
  • Morton, A.J., Faull, R.L.M. and Edwardson, J.M. (2001) Abnormalities in the synaptic vesicle fusion machinery in Huntington’s disease. Brain Research Bulletin 56, 111-117
  • Carter, R.J., Morton, A.J. and Dunnett, S.B. (2001) Motor co-ordination and balance in rodents. Current Protocols in Neuroscience pp 8.12.1-8.12.14 John Wiley and Sons.
  • Morton A.J. Hickey, M.A. and Dean, L.C. (2001) Methamphetamine toxicity in mice is potentiated by exposure to loud music. NeuroReport 12, 3277-3281

2000

  • Morton, A. J., Lagan, M. A., Skepper,, J. N. & Dunnett, S. B. (2000) Progressive formation of inclusions in the striatum and hippocampus of mice transgenic for the human Huntington's disease mutation Journal of Neurocytology,29, 681-705
  • Morton, A. J & Leavens, W. (2000) Mice transgenic for the human Huntington's Disease mutation have reduced sensitivity to kainic acid toxicity Brain Research Bulletin 52 (1) 52-59
  • Murphy, K. P. S. J ., Carter, R. J., Lione, L. A., Mangiarini, L., Mahal, A., Bates, G.P. Dunnett, S. B. & Morton, A. J. (2000) Abnormal synaptic plasticity and impaired spatial cognition in mice transgenic for the human Huntington's disease mutation. Journal of Neuroscience 20 (12) 5115-5223
  • Carter, R. J., Hunt, M.A. & Morton, A. J. (2000) Environmental stimulation increases survival in mice transgenic for exon 1 of the Huntington's Disease gene Movement Disorders 15 925-37
  • Hickey, M. A. & Morton (2000) Mice transgenic for the Huntington's Disease mutation are resistant to chronic 3-nitropropionic acid-induced striatal toxicity J Neurochmistry 75, 2163-71
  • Hickey, M.A. and Morton, A.J. (2000) Mice transgenic for the human Huntington’s disease mutation are not more susceptible to 3-nitropropionic acid than wild type mice. British Journal of Pharmacology 129, 87-88

1999

  • Carter, R.J., Lione, L.A., Humby, T., Mangiarini, L., Mahal, A., Bates, G.P. Dunnett, S.B. & Morton, A.J. (1999) Characterisation of progressive motor deficits in mice transgenic for the human Huntington's Disease mutation. Journal of Neuroscience 19, 3248-3257
  • Lione, L. A., Carter, R. J., Hunt, M. J., Bates, G.P., Morton, A. J. & Dunnett, S. B. (1999) Selective discrimination learning impairments in mice expressing the human Huntington's Disease mutation Journal of Neuroscience 19, 10428-10437.