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Department of Physiology, Development and Neuroscience

 
Read more at: Bill Colledge's previous research projects

Bill Colledge's previous research projects

Cystic fibrosis My laboratory has generated two different mouse models of cystic fibrosis (CF), CF null and ΔF508, and used these to perform successful gene therapy in vivo. These mice were vital for the preclinical testing of gene delivery reagents that allowed us to conduct two Phase I human...


Read more at: Bill Colledge's transgenics projects

Bill Colledge's transgenics projects

Manipulating the mouse genome Mice carrying genetic alterations can be made by manipulating embryonic stem (ES) cells. ES cells are usually derived from the inner cell mass of blastocyst stage embryos. Pre-implantation embryos are explanted into culture and attach to the substratum. The cells of...