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Franze lab - publications


Koser DE, Thompson AJ, Foster SK, Dwivedy A, Pillai EK, Sheridan GK, Svoboda H, Viana M, Costa LdF, Guck J, Holt CE, Franze K: Mechanosensing is critical for axon growth in the developing brain. Nature Neuroscience 19(12):1592-1598 (2016)

Sciacovelli M, Gonçalves E, Johnson TI, Zecchini VR, da Costa ASH, Gaude E, Drubbel AV, Theobald SJ, Abbo SR, Tran MGB, Rajeeve V, Cardaci S, Foster S, Yun H, Cutillas P, Warren A, Gnanapragasam V, Gottlieb E, Franze K, Huntly B, Maher ER, Maxwell PH, Saez-Rodriguez J, Frezza C: Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition. Nature 537(7621):544-547 (2016)

Holtzmann K, Gautier HOB, Christ AF, Guck J, Karadottir RT, Franze K: Brain tissue stiffness is a sensitive marker for acidosis. Journal of Neuroscience Methods 271:50–54 (2016)

Pearson JR, Zurita F, Tomás-Gallardo L, Díaz-Torres A, del Carmen Díaz de la Loza M, Franze K, Martín-Bermudo MD, González-Reyes A: ECM-regulator timp is required for stem cell niche organization and cyst production in the Drosophila ovary. PLOS Genetics 12(1):e1005763 (2016)



Jakobs M, Franze K, Zemel A: Force generation by molecular-motor powered microtubule bundles; implications for neuronal polarization and growth. Frontiers in Cellular Neuroscience 9:441 (2015)Cover JCB

MacDonald RB, Randlett O, Oswald J, Yoshimatsu T, Franze K*, Harris WA*: Muller Glia Provide Essential Tensile Strength to the Developing Retina. Journal of Cell Biology 210(7):1075–1083 (2015)

Bollmann L, Koser DE, Shahapure R, Gautier HOB, Holzapfel GA, Scarcelli G, Gather MC, Ulbricht E, Franze K: Microglia mechanics: immune activation alters traction forces and durotaxis. Frontiers in Cellular Neuroscience 9:363 (2015)

Bedzhov I, Bialecka M, Zielinska A, Kosalka J, Thompson AJ, Franze K, Zernicka-Goetz M: Development of the anterior-posterior axis is a self-organising process in the absence of maternal cues in mouse embryo. Cell Research 25:1368–1371 (2015)

Koser DE, Moeendarbary E, Hanne J, Kuerten S, Franze K: CNS cell distribution and axon orientation determine local spinal cord mechanical properties. Biophysical Journal 108(9):2137-2147 (2015)Cover BiophysJ

Randall A, Liu CH, Chu B, Zhang Q, Dongre S, Juusola M, Franze K, Wakelam M, Hardie R: Speed and sensitivity of phototransduction in Drosophila depend on degree of saturation of membrane phospholipids. Journal of Neuroscience 35(6): 2731-2746 (2015)

Gautier HOB, Thompson AJ, Achouri S, Koser DE, Holtzmann K, Moeendarbary E, Franze K: Atomic force microscopy-based force measurements on animal cells and tissues. Methods in Cell Biology (Volume 125) 125:211-235 (2015)



Pagliara S*, Franze K*, McClain CR, Wylde G, Fisher CL, Franklin RJM, Kabla AJ, Keyser UF, Chalut KJ: Auxetic nuclei in embryonic stem cells exiting pluripotency. Nature Materials 13:638-644 (2014)

Moshayedi P, Ng G, Kwok JC, Yeo GSH, Bryant C, Fawcett J, Franze K*, Guck J: The relationship between glial cell mechanosensitivity and foreign body reactions in the central nervous system. Biomaterials 35(13):3919-3925 (2014)



Franze K: The mechanical control of nervous system development. Development 140:3069-3077 (2013)

Franze K, Janmey P, Guck J: Mechanics in Neuronal Development and Repair. Annual Reviews in Biomedical Engineering 15:227-251 (2013)



Hardie RC, Franze K: Photomechanical responses in Drosophila photoreceptors. Science 338(6104):260-263 (2012)

Kuo CHR, Xian J, Brenton JD, Franze K*, Sivaniah E*: Complex stiffness gradient substrates for studying mechanotactic cell migration. Advanced Materials 24(45):6059-6064 (2012)Cover Advanced Materials

Kreysing M, Pusch R, Haverkate D, Landsberger M, Engelmann J, Ruiter J, Mora-Ferrer C, Ulbricht E, Grosche J, Franze K, Streif S, Schumacher S, Makarov F, Kacza J, Guck J, Wolburg H, Bowmaker J, von der Emde G, Schuster S, Wagner HJ, Reichenbach A, Francke M: Photonic Crystal Light Collectors in Fish Retina Improve Vision in Turbid Water. Science 336(6089):1700-1703 (2012)

Verho T, Korhonen JT, Sainiemi L, Jokinen V, Bower C, Franze K, Franssila S, Andrew P, Ikkala O, Ras RHA: Reversible Switching between Superhydrophobic States on a Hierarchically Structured Surface. Proc Natl Acad Sci USA 109(26):10210-10213 (2012)

Reichenbach A, Franze K, Agte S, Junek S, Wurm A, Grosche J, Savvinov A, Guck J, Skatchkov SN: Live Cells as Optical Fibers in the Vertebrate Retina. In Selected Topics on Optical Fiber Technology. M. Yasin, S. W. Harun and H. Arof, editors. InTech. (2012)



Franze K: Atomic force microscopy and its contribution to understanding the development of the nervous system.
Current Opinion in Genetics & Development 21(5):530-537 (2011)

Betz T, Koch D, Lu YB, Franze K, Käs J: Growth cones as soft and weak force generators. Proc Natl Acad Sci USA 108(33):13420-13425 (2011)



Franze K, Francke M, Guenter K, Christ AF, Koerber N, Reichenbach A, Guck J: Spatial mapping of the mechanical properties of the living retina using scanning force microscopy. Soft Matter 7(7):3147-3154 (2010)

Franze K & Guck J: The biophysics of neuronal growth. Reports on Progress in Physics 73(9):4601-4619 (2010)

Moshayedi P, da F Costa L, Christ AF, Lacour SP, Fawcett J, Guck J, Franze K: Mechanosensitivity of astrocytes on optimized polyacrylamide gels analyzed by quantitative morphometry, Journal of Physics: Condensed Matter 22(19), doi:10.1088/0953-8984/22/19/194114 (2010)

Christ AF, Franze K, Gautier H, Moshayedi P, Franklin RJM, Karadottir RT, Guck J: Mechanical difference between white and gray matter in the rat cerebellum measured by scanning force microscopy. Journal of Biomechanics 43(15):2986-92 (2010)

Poetes R, Holtzmann K, Franze K, Steiner U: Metastable underwater superhydrophobicity. Physical Review Letters 105(16), doi:10.1103/PhysRevLett.105.166104 (2010)

Lindqvist N, Liu Q, Zajadacz J, Franze K, Reichenbach A: Retinal Glial (Muller) Cells Sense and Respond to Tissue Stretch. Investigative Ophthalmology & Visual Science 51(3):1683-90 (2010)



Franze K, Gerdelmann J, Weick M, Betz T, Pawlizak S, Lakadamyali M, Bayer J, Rillich K, Gogler M, Lu YB, Reichenbach A, Janmey P, Kas J: Neurite branch retraction is caused by a threshold-dependent mechanical impact. Biophysical Journal 97(7):1883-1890 (2009)



Franze, K, Reichenbach A, Kas J: Biomechanics of the CNS. In Mechanosensitivity in Cells and Tissues: Nervous system, A. Kamkin and I. Kiseleva, editors. Springer, New York (2008)



Franze K, Grosche J, Skatchkov SN, Schinkinger S, Foja C, Schild D, Uckermann O, Travis K, Reichenbach A, Guck J: Muller cells are living optical fibers in the vertebrate retina. Proc Natl Acad Sci USA 104(20):8287-8292 (2007)

Ehrlicher A, Betz T, Stuhrmann B, Gogler M, Koch D, Franze K, Lu YB, Kas J: Optical Neuronal Guidance, Methods in Cell Biology 83:495-520 (2007)



Lu YB*, Franze K*, Steinhauser C, Kirchhoff F, Wolburg H, Guck J, Janmey P, Kas J, Reichenbach A: Viscoelastic properties of individual glial cells and neurons in the CNS. Proc Natl Acad Sci USA 103(47):17759-17764 (2006) 



Biedermann B, Bringmann A, Franze K, Faude F, Wiedemann P, Reichenbach A: GABA(A) receptors in Muller glial cells of the human retina. Glia 46(3):302-310 (2004)

Uckermann O, Iandiev I, Francke M, Franze K, Grosche J, Wolf S, Kohen L, Wiedemann P, Reichenbach A, Bringmann A: Selective staining by vital dyes of Müller glial cells in retinal wholemounts. Glia 45(1):59-66 (2004)


Media exposure (selection)

Interview by The Node (The Company of Biologists), 12/2016

Interview by Cambridge TV, 09/2016

Brain's physical structure may help guide its wiring
ScienceNews, 9/2016

Neurons feel the force—physical interactions control brain development
Medical Xpress, 9/2016

Researchers Identify New Mechanism Controlling Brain Development
Scicasts, 9/2016

Interview by Varsity, the oldest of Cambridge University's main student newspapers, 10/2015

Interview by ZDF (one of the two major German TV stations), shown in prime time news, 02/2014

Filling me softly: Implant stiffness is a major cause of foreign body reactions
PhysOrg, 02/2014

Fruit flies' eyes shrink a little to see
New Scientist, 10/2012

Fly eye mystery: Why flies have fastest vision in animal kingdom
PhysOrg, 10/2012

‘Optical fibres’ aid vision in our backward eyes
NewScientist 5/2010

Franze K: Und es ward Sicht
Bild der Wissenschaft 9/2008

Franze K & Grosche J: Müllerzellen in einem anderen Licht
BIOspektrum 7/2008

Franze K & Reichenbach A: Gliazellen als Lichtleiter
Interview by MDR radio station 12/2007

Franze K: Lichtleiter in der Netzhaut
Spektrum der Wissenschaft 10/2007

Franze K: Und es ward Sicht
Gehirn & Geist, 7-8/2007

Franze K & Grosche J: Lebende Lichtleiter in der Netzhaut
BIOforum 4/2007