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Research interests

FlyBase is a database of genetic, genomic and functional data for Drosophila species, with a focus on the model organism Drosophila melanogaster. We integrate information from the research literature and various external databases and projects, and make these data available to the research community via our public website. In so doing, FlyBase provides an essential bioinformatic resource to the genetics, genomics and biomedical research communities all over the world.

The FlyBase project is a collaboration between four groups based at Harvard University, USA (PIs Norbert Perrimon and Cassandra Extavour); Indiana University, USA (PI Thom Kaufman); The University of New Mexico, USA (PIs Maggie Werner-Washburne and Richard Cripps); and The University of Cambridge, UK (PI Nick Brown).

The FlyBase-Cambridge division comprises a team of literature curators and an ontologist. Our primary task is to identify genetic data from scientific articles concerning Drosophila and to record these data in a systematic manner. Relevant data include all genetic entities (genes, alleles, transgenic constructs, etc.) and certain types of associated information such as phenotypes, genetic interactions, gene product functions and models of human disease. Curated data are subsequently integrated into the FlyBase database and website.

Other responsibilities of FlyBase-Cambridge include the maintenance of the FlyBase bibliography, and the development of controlled vocabularies (ontologies) used in literature curation.

Enquiries regarding FlyBase-Cambridge should be sent to the Group Manager, Steven Marygold. General enquires and feedback about FlyBase should be communicated using the Contact FlyBase form.

Key publications

Millburn GH, Crosby MA, Gramates LS, Tweedie S; FlyBase Consortium. (2016)
FlyBase portals to human disease research using Drosophila models.
Dis. Model Mech. 9(3):245-252

Attrill H, Falls K, Goodman JL, Millburn GH, Antonazzo G, Rey AJ, Marygold SJ; the FlyBase Consortium. (2016) FlyBase: establishing a Gene Group resource for Drosophila melanogaster. Nucleic Acids Res. 44 (D1): D786-D792.

Matthews BB, dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM, and the FlyBase Consortium. (2015) Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data. G3 (Bethesda) 5:1721-1736.

Dos Santos G, Schroeder AJ, Goodman JL, Strelets VB, Crosby MA, Thurmond J, Emmert DB, Gelbart WM; the FlyBase Consortium. (2015) FlyBase: introduction of the Drosophila melanogaster Release 6 reference genome assembly and large-scale migration of genome annotations. Nucleic Acids Res. 43(Database issue): D690-D697.

Contact details

Group Leader: Professor Nick Brown
Tel: +44 (0)1223 334128

Group Manager: Dr Steven Marygold
Tel: +44 (0)1223 333170

Senior Curator: Dr Gillian Millburn
Tel: +44(0)1223 333865

Group members