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Dr Megan Sutherland

My research is focussed on determining the long-term impact of chronic fetal hypoxia on the kidneys, and whether antenatal antioxidant (vitamin C) treatment can prevent any adverse renal consequences.
Dr Megan Sutherland

Visiting Academic (Postdoctoral Fellow)


Office Phone: +44 (0) 1223 333 816

Research Interests

Kidney Development: During gestation the nephrons (functional units of the kidneys) are formed; once development is completed, no new nephrons are formed for your lifetime. Therefore, it is essential for life-long renal health that the number of nephrons formed are optimised during fetal life.

Chronic Fetal Hypoxia: A low oxygen supply to the developing fetus occurs in numerous conditions during pregnancy, such as pre-eclampsia and placental insufficiency. This results in growth restriction of the fetus, including impaired development of the kidneys. Using a large animal (ovine) model, current research is focussed on investigating the long-term impact of fetal hypoxia on the kidneys. Furthermore, maternal Vitamin C administration is being investigated as a possible treatment to ameliorate the effects of fetal hypoxia on kidney development.

Collaborators

Prof Dino Giussani

Key Publications

Sutherland MR, Bertagnolli M, Lukaszewski MA, Huyard F, Yzydorczyk C, Luu TM, Nuyt AM, (2014), Preterm birth and hypertension risk: The oxidative stress paradigm, Hypertension, 63(1):12-18

Popescu CR*, Sutherland MR*, Cloutier A, Benoît G, Bertagnolli M, Yzydorczyk C, Germain N, Phan V, Lelièvre-Pegorier M, Sartelet H, Nuyt AM, (2013), Hyperoxia exposure impairs nephrogenesis in the neonatal rat: Role of HIF-1α, PLoS One, 8(12):e82421 (*joint first authors)

Sutherland MR, O’Reilly M, Kenna K, Ong K, Sozo F, Harding R, Black MJ, (2013), Neonatal hyperoxia: Effects on nephrogenesis and long-term glomerular structure, Am J Physiol Renal Physiol, 304(10):F1308-1316 

Sutherland MR*, Gubhaju L*, Moore L, Kent AL, Dahlstrom JE, Horne RS, Hoy WE, Bertram JF, Black MJ, (2011), Accelerated maturation and abnormal morphology in the preterm neonatal kidney, J Am Soc Nephrol, 22(7):1365-74 (*joint first authors)

Gubhaju L*, Sutherland MR*, Horne RS, Medhurst A, Kent AL, Ramsden A, Moore L, Singh G, Hoy WE, Black MJ, (2014), Assessment of renal functional maturation and injury in preterm neonates during the first month of life, Am J Physiol Renal Physiol, [Epub ahead of print] (*joint first authors)

Gubhaju L, Sutherland MR, Black MJ, (2011), Preterm birth and the kidney: implications for long-term renal health, Reprod Sci, 18(4):322-33

Sutherland MR, Gubhaju L, Black MJ, (2011), Stereological assessment of renal development in a baboon model of preterm birth, Am J Nephrol, 33(Suppl 1):25-33

Sutherland MR, Yoder BA, McCurnin D, Seidner S, Gubhaju L, Clyman RI, Black MJ, (2012), Effects of ibuprofen treatment on the developing preterm baboon kidney, Am J Physiol Renal Physiol, 302(10):F1286-92

Sutherland MR, Gubhaju L, Yoder BA, Stahlman MT, Black MJ, (2009), The effects of postnatal retinoic acid administration on nephron endowment in the preterm baboon kidney, Pediatr Res, 65(4):397-402

Gubhaju L, Sutherland MR, Yoder BA, Zulli A, Bertram JF, Black MJ, (2009), Is nephrogenesis affected by preterm birth? Studies in a non-human primate model, Am J Physiol Renal Physiol, 297:F1668-77

Above: Glomerulus from the outer renal cortex of a 9-month old lamb. A cross-section of the kidney shown is shown in the inset.