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Dr Peter F P Wooding

Comparative studies on placenta and mammary gland structure and function.
Dr Peter F P Wooding

Honorary Senior Research Associate (retired)


Office Phone: +44 (0) 1223 333868

Research Interests

Light and Electron microscope immunocytochemical investigations of the mechanisms of Placental growth, development and function and Mammary Gland secretion.  The main focus is on Ruminant species but the wider comparative aspects are also important.

Collaborators

Professor Abby Fowden
Professor Dino Giussani
Dr Alison Forhead
Dr CJP Jones, Manchester University
Professor J A Green, Missouri University, USA

Teaching

1A1B NST Histology

Key Publications

Wooding FBP, Sargeant TJ (2015), Immunocytochemical evidence for golgi vesicle involvement in milk fat globule secretion, Journal of Histochemistry and Cytochemistry, [in press]

Wooding FBP, Wilsher S, Benirschke K, Jones CJP, Allen WR (2015), Immunocytochemistry of the placentas of Giraffe and Okapi: comparison with other ruminants, Placenta, [in press]

Wooding FBP, Burton G, (2008), Comparative placentation: structures, functions and evolution, Berlin, Springer

Wooding FBP, Fowden AL, Bell AW, Ehrhardt RA, Limesand SW, Hay WW, (2005), Localisation of glucose transport in the Ruminant placenta: implications forthe sequential use of transporter isoforms, Placenta, 26:626-40

Wooding FBP, Roberts RM, Green JA, (2005), Light and electron immunocyto-chemical studies of the distribution of PAGs throughout pregnancy in the cow: possible functional implications, Placenta, 26:807-27

Above: Electron Micrograph illustrating the unique characteristic of all Ruminant placentas: formation of fetomaternal syncytia by migration and fusion of specialised fetal binucleate cells[BNC] with the maternal uterine epithelial cells. BNC synthesise granules containing a hormone, placental lactogen, localised immunocytochemically on this section with gold granules, see the inserts. The granules are delivered to the syncytium and released by exocytosis to the maternal blood vessels [ see the asterisk]. This process allows the fetus send biochemical signals directly to the mother throughout pregnancy. Similar granules in the uninucleate trophoblast cells show no label [see central insert]. Expand the image.

Above: Serial electron micrographs of horse placenta showing that  glucose molecules must use two isoforms of the glucose transporter to travel from maternal to fetal circulations. The isoforms are immunocytochemically localised with gold granules. Expand the image.