Professor Andrew Murray
- Professor of Metabolic Physiology
- Deputy Director of Postgraduate Education
- Impact, Translation and Enterprise Champion
Research
Our work is concerned with mitochondrial function; how this is altered in metabolic diseases, during development and ageing, and with changes in diet, exercise and oxygen; and what effects these changes have on physiological performance. We aim to elucidate the causes of mitochondrial dysfunction and the impact this has on function at the level of the tissue, intact organ and whole body.
Mitochondrial function in health and diseaseOur interest lies in the control of mitochondrial respiration and energy metabolism. We are interested in the metabolic response to dietary manipulation and alterations in oxygen supply, including the matching of oxygen demand and supply. We study this in cells, tissues, animal models and healthy humans at high altitude, and in relation to diseases such as heart failure, COPD, anaemia and pathologies of pregnancy such as preeclampsia. A major recent interest is the role of dietary nitrate in the regulation of metabolism.
CollaboratorsResearch team
Dr Katie O’Brien
Mrs Sarah Millington-Burgess (British Heart Foundation funded student)
Miss Alice Sowton (British Heart Foundation funded student)
Mr Lorenz Holzner (Wellcome Trust funded student)
Miss Paula Darwin (BBSRC CASE funded student)
Previous team members
Dr Tom Ashmore
Dr Helen Atherton
Dr Francesca Colleoni
Dr James Horscroft
Dr Aleksandra Kotwica
Dr Ross Lindsay
Dr David Menassa
Dr Andrea Morash
Dr Augustine Ocloo
Main research collaborators
Professor Graham Burton (PDN)
Professor Kieran Clarke (University of Oxford)
Professor Florin Despa (University of Kentucky, USA)
Professor Martin Feelisch (University of Southampton)
Professor Abby Fowden (PDN)
Professor Dino Giussani (PDN)
Professor Erich Gnaiger (University of Innsbruck, Austria)
Professor Julian Griffin (Dept. of Biochemistry, University of Cambridge)
Professor Mike Grocott (University of Southampton)
Professor Hugh Montgomery (UCL)
Dr Lee Roberts (University of Leeds)
Teaching and supervision
Course Organiser - 1B NST Physiology
Lecturer - 1A NST Physiology of Organisms, 1B NST Physiology, Part 2 PDN Systems and Clinical Physiology