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Department of Physiology, Development and Neuroscience

 
Read more at: Transcription factor HIF2a necessary for the development and function of the carotid body.
Transcription factor HIF2a necessary for the development and function of the carotid body.

Transcription factor HIF2a necessary for the development and function of the carotid body.

30 April 2018

Study by Randall Johnson's lab uses genetic and physiological analysis to demonstrate the essential role of the transcription factor HIF-2alpha in the sympathetic nervous system control of the ventilatory response to hypoxia


Read more at: Study shows how muscles regulate their oxygen consumption
Study shows how muscles regulate their oxygen consumption

Study shows how muscles regulate their oxygen consumption

27 March 2018

A new study by Randall Johnson published in Cell Metabolism shows that an enzyme called FIH determines how muscles consume oxygen. Without the enzyme, the need for oxygen increases during physical exercise. The finding is of potential significance to elite athletes, who have been found to have higher levels of FIH in their muscles than others.


Read more at: Harder for T cells to fight cancer in absence of VEGF-A
Harder for T cells to fight cancer in absence of VEGF-A

Harder for T cells to fight cancer in absence of VEGF-A

13 November 2017

New research by Randall Johnson about the role of VEGF-A in helping T-cells in low oxygen environments makes the cover of Cancer Cell


Read more at: Skin found to play a role in controlling blood pressure
Skin found to play a role in controlling blood pressure

Skin found to play a role in controlling blood pressure

24 October 2017

New study by Randall Johnson on eLife shows that skin reacts to the changes in oxygen in the air to regulate blood pressure and hearth rate


Read more at: Self-renewable killer cells could be key to making cancer immunotherapy work
Self-renewable killer cells could be key to making cancer immunotherapy work

Self-renewable killer cells could be key to making cancer immunotherapy work

26 October 2016

New research from Randall Johnson's team, published on Nature, reveals how a small molecule turns short-lived ‘killer T-cells’ into long-lived, renewable cells that can last in the body for longer, and could help make cell-based immunotherapy a realistic prospect to treat cancer.