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Department of Physiology, Development and Neuroscience

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A 3D cell shape that enables tube formation

A 3D cell shape that enables tube formation

New modelling and in vivo observations reveal that cells in tubes adopt an asymmetric cell shape dubbed scutoid, contrary to some previous assumptions

A 3D cell shape that enables tube formation - Read More…

How flat sheets of cells become tubular organs

How flat sheets of cells become tubular organs

New research by Guy Blanchard in collaboration with the LMB Cell Biology Division gives new insight into how flat layers of cell tissue develop into 3D structures

How flat sheets of cells become tubular organs - Read More…

Rapid Cue-Specific Remodeling of the Nascent Axonal Proteome

Rapid Cue-Specific Remodeling of the Nascent Axonal Proteome

The Holt lab at PDN has developed a new method to identify newly synthesized axonal proteins in response to axon guidance cues. Axons stimulated by different guidance cues show distinct and common signatures.

Rapid Cue-Specific Remodeling of the Nascent Axonal Proteome - Read More…

PDN scientists generate key life event in artificial mouse ‘embryo’ created from stem cells

PDN scientists generate key life event in artificial mouse ‘embryo’ created from stem cells

The creation of artificial embryos has moved a step forward after an international team lead by Magda Zernicka-Goetz used mouse stem cells to produce artificial embryo-like structures capable of ‘gastrulation’, a key step in the life of any embryo

PDN scientists generate key life event in artificial mouse ‘embryo’ created from stem cells - Read More…

Amanda Sferruzzi-Perri awarded Lister Prize Fellowship

Amanda Sferruzzi-Perri awarded Lister Prize Fellowship

The Lister Institute provides research funding to outstanding early career scientists whose work shows excellent potential to make an impact in the field of biomedical sciences

Amanda Sferruzzi-Perri awarded Lister Prize Fellowship - Read More…

Five members of Dino Giussani's group awarded prizes at international meeting

Five members of Dino Giussani's group awarded prizes at international meeting

Postdocs, PhDs and undergraduate members of Dino's group receive awards at the Society for Reproductive Investigation 65th Annual International Meeting

Five members of Dino Giussani's group awarded prizes at international meeting - Read More…

Prof Ewa Paluch awarded EMBO membership

Prof Ewa Paluch awarded EMBO membership

PDN's Director of Research among 62 newly selected member of European research organization

Prof Ewa Paluch awarded EMBO membership - Read More…

Wolfram Schultz awarded The 2018 Gruber Neuroscience Prize

Wolfram Schultz awarded The 2018 Gruber Neuroscience Prize

The PDN neuroscientist received the joint award for his work on the structure, organization and functions of the basal ganglia

Wolfram Schultz awarded The 2018 Gruber Neuroscience Prize - Read More…

The game of fate: tracing the origin of heterogeneity and symmetry breaking in the early mammalian embryo

The game of fate: tracing the origin of heterogeneity and symmetry breaking in the early mammalian embryo

New paper on Nature Communications by Magda Zernicka Goetz in collaboration with researchers from the University of Nevada digs into one of the central questions of developmental biology, single cell differentiation

The game of fate: tracing the origin of heterogeneity and symmetry breaking in the early mammalian embryo - Read More…

How muscle satellite-like cells remain undifferentiated

How muscle satellite-like cells remain undifferentiated

New study by Hadi Boukhatmi and Sarah Bray shows population of adult satellite-like cells in Drosophila maintained through a switch in RNA-isoforms

How muscle satellite-like cells remain undifferentiated - Read More…

Transcription factor HIF2a necessary for the development and function of the carotid body.

Transcription factor HIF2a necessary for the development and function of the carotid body.

Study by Randall Johnson's lab uses genetic and physiological analysis to demonstrate the essential role of the transcription factor HIF-2alpha in the sympathetic nervous system control of the ventilatory response to hypoxia

Transcription factor HIF2a necessary for the development and function of the carotid body. - Read More…

Mechanism behind neuron death in motor neurone disease and frontotemporal dementia discovered

Mechanism behind neuron death in motor neurone disease and frontotemporal dementia discovered

Scientists from Christine Holt lab in collaboration with the University of Toronto have identified the molecular mechanism that leads to the death of neurons in amyotrophic lateral sclerosis (also known as ALS or motor neurone disease) and a common form of frontotemporal dementia.

Mechanism behind neuron death in motor neurone disease and frontotemporal dementia discovered - Read More…

‘Sleeping’ stem cells could aid regenerative medicine for brain repair

‘Sleeping’ stem cells could aid regenerative medicine for brain repair

Scientists at the Wellcome Trust/ Cancer Research UK Gurdon Institute, University of Cambridge, have identified a new type of stem cell in the brain which they say has a high potential for repair following brain injury or disease.

‘Sleeping’ stem cells could aid regenerative medicine for brain repair - Read More…

New studies describe role of glutamate receptor ion channels in cancer progression

New studies describe role of glutamate receptor ion channels in cancer progression

Two studies published in Open Biology and Cancer Cell, co-authored by Hugh Robinson, have shed new light on how glutamate receptor ion channels are involved in cancer progression

New studies describe role of glutamate receptor ion channels in cancer progression - Read More…

Study shows how muscles regulate their oxygen consumption

Study shows how muscles regulate their oxygen consumption

A new study by Randall Johnson published in Cell Metabolism shows that an enzyme called FIH determines how muscles consume oxygen. Without the enzyme, the need for oxygen increases during physical exercise. The finding is of potential significance to elite athletes, who have been found to have higher levels of FIH in their muscles than others.

Study shows how muscles regulate their oxygen consumption - Read More…

Azim Surani to receive coveted Canada Gairdner International Award for discovery of genomic imprinting

Azim Surani to receive coveted Canada Gairdner International Award for discovery of genomic imprinting

Azim Surani of the Gurdon Institute and Davor Solter of the Max Planck Institute of Immunobiology and Epigenetics will receive Canada's top research award from the Gairdner Foundation in recognition of their work establishing the field of epigenetics with the discovery of genomic imprinting

Azim Surani to receive coveted Canada Gairdner International Award for discovery of genomic imprinting - Read More…

The world's highest lab is uncovering the secrets of extreme fitness

The world's highest lab is uncovering the secrets of extreme fitness

Andrew Murray, part of the Xtreme Everest project, was interviewed by Wired Magazine on the difficulties of testing Sherpas in high altitude, low oxygen environments

The world's highest lab is uncovering the secrets of extreme fitness - Read More…

Dr Matt Mason awarded 2018 Pilkington Prize

Dr Matt Mason awarded 2018 Pilkington Prize

The Pilkington Prize award acknowledges excellence in teaching at the University of Cambridge

Dr Matt Mason awarded 2018 Pilkington Prize - Read More…

How the brain tidies up memories during sleep

How the brain tidies up memories during sleep

Connections between brain cells are refined during sleep in a way that makes a memory stand out without interfering with previously stored memories, new study by Ole Paulsen's group shows

How the brain tidies up memories during sleep - Read More…

The body in miniature - organoid research at Meritxell Huch's lab

The body in miniature - organoid research at Meritxell Huch's lab

Dr Laura Broutier from Huch's lab interviewed about recent advancements in organoids on the latest issue of Research Horizons

The body in miniature - organoid research at Meritxell Huch's lab - Read More…

PDN scientists discover the secrets behind the cuttlefish’s 3D ‘invisibility cloak’

PDN scientists discover the secrets behind the cuttlefish’s 3D ‘invisibility cloak’

An international team of scientists led by Trevor Wardill has identified the neural circuits that enable cuttlefish to change their appearance in just the blink to eye – and discovered that this is similar to the neural circuit that controls iridescence in squids.

PDN scientists discover the secrets behind the cuttlefish’s 3D ‘invisibility cloak’ - Read More…

The honeycomb maze provides a novel test to study hippocampal-dependent spatial navigation

The honeycomb maze provides a novel test to study hippocampal-dependent spatial navigation

A powerful new tool for the study of spatial memory was today described in Nature as a significant improvement over the standard, the Morris Water Maze. The study was led by the Sainsbury Wellcome Centre in collaboration with PDN's Julija Krupic

The honeycomb maze provides a novel test to study hippocampal-dependent spatial navigation - Read More…

Female sexual behavior in mice is controlled by kisspeptin neurons

Female sexual behavior in mice is controlled by kisspeptin neurons

An international research team which included Prof Bill Colledge has made a major advancement in understanding how the brain controls sexual behaviour, published in Nature Communications.

Female sexual behavior in mice is controlled by kisspeptin neurons - Read More…

Meritxell Huch awarded WICB Medal

Meritxell Huch awarded WICB Medal

Dr Meritxell has received the 2018 Women in Cell Biology Early Career Medal from the British Society for Cell Biology

Meritxell Huch awarded WICB Medal - Read More…

OCD film wins Openness Award for depiction of animal research at Cambridge

A series of films illustrating how research using animals is helping further our understanding of obsessive compulsive disorder (OCD) was awarded the 2017 Openness Award in the category of Website or Use of New Media

OCD film wins Openness Award for depiction of animal research at Cambridge - Read More…

Scientists at PDN shed light on the mechanisms of early pregnancy loss

Scientists at PDN shed light on the mechanisms of early pregnancy loss

Using a newly developed technique to culture mouse and human embryos in vitro beyond implantation, PDN researchers led by Magdalena Zernicka-Goetz show how alteration of the first morphological transformation can lead to pregnancy termination

Scientists at PDN shed light on the mechanisms of early pregnancy loss - Read More…

Dino Giussani given 2017 Nick Hales Award

Dino Giussani given 2017 Nick Hales Award

Prof Giussani has received the prize from the International Society for Developmental Origins of Health & Disease

Dino Giussani given 2017 Nick Hales Award - Read More…