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Department of Physiology, Development and Neuroscience

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CTR members awarded prizes at SRI meeting

CTR members awarded prizes at SRI meeting

Several members of the Centre for Trophoblast research receive prizes during the 66th meeting of the Society for Reproductive Investigation in Paris

CTR members awarded prizes at SRI meeting - Read More…

Cambridge University ranked No 1 for study of anatomy and physiology

Cambridge University ranked No 1 for study of anatomy and physiology

According to the Higher Education Statistics Agency, Cambridge tops the worldwide chart for the subjects of anatomy and physiology, increasing its score from the previous year

Cambridge University ranked No 1 for study of anatomy and physiology - Read More…

Noncanonical Modulation of the eIF2 Pathway Controls an Increase in Local Translation during Neural Wiring

Noncanonical Modulation of the eIF2 Pathway Controls an Increase in Local Translation during Neural Wiring

New research by Christine Holt’s laboratory reveals a cue-induced noncanonical mechanism of translation regulation in axons, which is required for the development of the visual pathway.

Noncanonical Modulation of the eIF2 Pathway Controls an Increase in Local Translation during Neural Wiring - Read More…

Boosting glutamate reduces anxiety in monkeys

Boosting glutamate reduces anxiety in monkeys

New study led by Hannah Clarke, published in JNeurosci, show that increasing levels of the neurotransmitter glutamate in the hippocampus normalizes anxious monkey’s “fight or flight” response

Boosting glutamate reduces anxiety in monkeys - Read More…

Heart disease risk begins in the womb, study in sheep suggests

Heart disease risk begins in the womb, study in sheep suggests

Offspring whose mothers had a complicated pregnancy may be at greater risk of heart disease in later life, according to a new study in sheep by Dino Giussani's lab

Heart disease risk begins in the womb, study in sheep suggests - Read More…

Placentas adapt to help keep babies healthy when mothers have poor diets or low oxygen during pregnancy

Placentas adapt to help keep babies healthy when mothers have poor diets or low oxygen during pregnancy

CTR researchers have discovered the placenta regulates how much oxygen and nutrients it transports to babies during challenging pregnancies in a study using mice to model conditions in the womb

Placentas adapt to help keep babies healthy when mothers have poor diets or low oxygen during pregnancy - Read More…

Former PDN student awarded Anatomical Society Best Image prize

Former PDN student awarded Anatomical Society Best Image prize

Léa Wenger, a former part 2 student, has just been awarded the runner-up prize of the Anatomical Society Best Image competition

Former PDN student awarded Anatomical Society Best Image prize - Read More…

Mechanics paves the way for nerve cells

Mechanics paves the way for nerve cells

By tracking real-time changes in physical properties of the embryonic brain, researchers from the Franze lab have shown that changes in brain stiffness tell growing nerve cells which way to turn

Mechanics paves the way for nerve cells - Read More…

Late endosomes serve as mRNA translation platforms and help to sustain mitochondrial health in axon

Late endosomes serve as mRNA translation platforms and help to sustain mitochondrial health in axon

New research by Christine Holt and colleagues published in Cell shows that late endosomes serve as mRNA translation platforms and help to sustain mitochondrial health in the axons of neurons

Late endosomes serve as mRNA translation platforms and help to sustain mitochondrial health in axon - Read More…

Ewa Paluch receives 2019 Blavatnik Award for Young Scientists in the UK

Ewa Paluch receives 2019 Blavatnik Award for Young Scientists in the UK

Prof Paluch is the 2019 Laureate in Life Sciences and will receive the award and associated cash prize at the March Blavatnik Awards Ceremony to be held at the V&A.

Ewa Paluch receives 2019 Blavatnik Award for Young Scientists in the UK - Read More…

PDN Part II students awarded BACA prize

Two of our Part II PDN students from last year who did anatomy projects with the Human Anatomy Teaching Group have been awarded the prize for best oral presentation at the BACA (British Association of Clinical Anatomists) and Anatomical Society meetings

PDN Part II students awarded BACA prize - Read More…

CTR study on mini placentas makes Guardian 2018 science stories list

CTR study on mini placentas makes Guardian 2018 science stories list

The miniature placenta study by Margherita Turco and her CTR colleagues has been featured in a list of science stories that shook 2018 by The Guardian

CTR study on mini placentas makes Guardian 2018 science stories list - Read More…

Using the marmoset brain to understand depression

Using the marmoset brain to understand depression

Marmoset study by the Roberts lab shows how over-activity in a specific area of the brain’s frontal lobe blunts the anticipatory excitement and motivation for reward – core symptoms of depression.

Using the marmoset brain to understand depression - Read More…

Physical forces, not shape, identified as driving factor of cell division direction

Physical forces, not shape, identified as driving factor of cell division direction

Study by the Sanson Lab published in Developmental Cell sheds light on the driving mechanisms that determine the direction of the plane of division during development

Physical forces, not shape, identified as driving factor of cell division direction - Read More…

‘Mini-placentas’ could provide a model for early pregnancy

‘Mini-placentas’ could provide a model for early pregnancy

PDN researchers say that new ‘mini-placentas’ – a cellular model of the early stages of the placenta – could provide a window into early pregnancy and help transform our understanding of reproductive disorders. Details of this new research are published today in the journal Nature.

‘Mini-placentas’ could provide a model for early pregnancy - Read More…

Single-cell reconstruction of the early maternal–fetal interface in humans

Single-cell reconstruction of the early maternal–fetal interface in humans

Transcriptomes of about 70,000 single cells from first-trimester deciduas and placentas reveal subsets of perivascular, stromal and natural killer cells in the decidua, according to new research by CTR published on Nature

Single-cell reconstruction of the early maternal–fetal interface in humans - Read More…

New mechanisms of action for platelet inhibition identified

New mechanisms of action for platelet inhibition identified

Study by Gavin Jarvis on citalopram-induced platelet inhibition reports evidence for two novel and putative mechanisms of inhibition

New mechanisms of action for platelet inhibition identified - Read More…

Predatory flies use "homing missile" system to intercept preys mid-air

Predatory flies use "homing missile" system to intercept preys mid-air

New study by Gonzalez-Bellido lab published on the Journal of the Royal Society Interface sheds light on the underlying system behind predation and navigation in insects

Predatory flies use "homing missile" system to intercept preys mid-air - Read More…

Sequential formation and resolution of multiple rosettes drive embryo remodelling after implantation

Sequential formation and resolution of multiple rosettes drive embryo remodelling after implantation

New study by Magda Zernicka-Goetz's lab on Nature Cell Biology examines the mechanisms of cavity formation during development for the correct formation of the embryo

Sequential formation and resolution of multiple rosettes drive embryo remodelling after implantation - Read More…

PDN receives Green Impact Excellence Award

PDN receives Green Impact Excellence Award

The Vice Chancellor has awarded our Department with the Green Impact Excellence Award for its commitment to waste reduction

PDN receives Green Impact Excellence Award - Read More…

A 3D cell shape that enables tube formation

A 3D cell shape that enables tube formation

New modelling and in vivo observations reveal that cells in tubes adopt an asymmetric cell shape dubbed scutoid, contrary to some previous assumptions

A 3D cell shape that enables tube formation - Read More…

How flat sheets of cells become tubular organs

How flat sheets of cells become tubular organs

New research by Guy Blanchard in collaboration with the LMB Cell Biology Division gives new insight into how flat layers of cell tissue develop into 3D structures

How flat sheets of cells become tubular organs - Read More…

Rapid Cue-Specific Remodeling of the Nascent Axonal Proteome

Rapid Cue-Specific Remodeling of the Nascent Axonal Proteome

The Holt lab at PDN has developed a new method to identify newly synthesized axonal proteins in response to axon guidance cues. Axons stimulated by different guidance cues show distinct and common signatures.

Rapid Cue-Specific Remodeling of the Nascent Axonal Proteome - Read More…

PDN scientists generate key life event in artificial mouse ‘embryo’ created from stem cells

PDN scientists generate key life event in artificial mouse ‘embryo’ created from stem cells

The creation of artificial embryos has moved a step forward after an international team lead by Magda Zernicka-Goetz used mouse stem cells to produce artificial embryo-like structures capable of ‘gastrulation’, a key step in the life of any embryo

PDN scientists generate key life event in artificial mouse ‘embryo’ created from stem cells - Read More…

Amanda Sferruzzi-Perri awarded Lister Prize Fellowship

Amanda Sferruzzi-Perri awarded Lister Prize Fellowship

The Lister Institute provides research funding to outstanding early career scientists whose work shows excellent potential to make an impact in the field of biomedical sciences

Amanda Sferruzzi-Perri awarded Lister Prize Fellowship - Read More…

Five members of Dino Giussani's group awarded prizes at international meeting

Five members of Dino Giussani's group awarded prizes at international meeting

Postdocs, PhDs and undergraduate members of Dino's group receive awards at the Society for Reproductive Investigation 65th Annual International Meeting

Five members of Dino Giussani's group awarded prizes at international meeting - Read More…

Prof Ewa Paluch awarded EMBO membership

Prof Ewa Paluch awarded EMBO membership

PDN's Director of Research among 62 newly selected member of European research organization

Prof Ewa Paluch awarded EMBO membership - Read More…

Wolfram Schultz awarded The 2018 Gruber Neuroscience Prize

Wolfram Schultz awarded The 2018 Gruber Neuroscience Prize

The PDN neuroscientist received the joint award for his work on the structure, organization and functions of the basal ganglia

Wolfram Schultz awarded The 2018 Gruber Neuroscience Prize - Read More…