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Department of Physiology, Development and Neuroscience

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Using the marmoset brain to understand depression

Using the marmoset brain to understand depression

Marmoset study by the Roberts lab shows how over-activity in a specific area of the brain’s frontal lobe blunts the anticipatory excitement and motivation for reward – core symptoms of depression.

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Physical forces, not shape, identified as driving factor of cell division direction

Physical forces, not shape, identified as driving factor of cell division direction

Study by the Sanson Lab published in Developmental Cell sheds light on the driving mechanisms that determine the direction of the plane of division during development

Physical forces, not shape, identified as driving factor of cell division direction - Read More…

‘Mini-placentas’ could provide a model for early pregnancy

‘Mini-placentas’ could provide a model for early pregnancy

PDN researchers say that new ‘mini-placentas’ – a cellular model of the early stages of the placenta – could provide a window into early pregnancy and help transform our understanding of reproductive disorders. Details of this new research are published today in the journal Nature.

‘Mini-placentas’ could provide a model for early pregnancy - Read More…

Single-cell reconstruction of the early maternal–fetal interface in humans

Single-cell reconstruction of the early maternal–fetal interface in humans

Transcriptomes of about 70,000 single cells from first-trimester deciduas and placentas reveal subsets of perivascular, stromal and natural killer cells in the decidua, according to new research by CTR published on Nature

Single-cell reconstruction of the early maternal–fetal interface in humans - Read More…

New mechanisms of action for platelet inhibition identified

New mechanisms of action for platelet inhibition identified

Study by Gavin Jarvis on citalopram-induced platelet inhibition reports evidence for two novel and putative mechanisms of inhibition

New mechanisms of action for platelet inhibition identified - Read More…

Predatory flies use "homing missile" system to intercept preys mid-air

Predatory flies use "homing missile" system to intercept preys mid-air

New study by Gonzalez-Bellido lab published on the Journal of the Royal Society Interface sheds light on the underlying system behind predation and navigation in insects

Predatory flies use "homing missile" system to intercept preys mid-air - Read More…

Sequential formation and resolution of multiple rosettes drive embryo remodelling after implantation

Sequential formation and resolution of multiple rosettes drive embryo remodelling after implantation

New study by Magda Zernicka-Goetz's lab on Nature Cell Biology examines the mechanisms of cavity formation during development for the correct formation of the embryo

Sequential formation and resolution of multiple rosettes drive embryo remodelling after implantation - Read More…

PDN receives Green Impact Excellence Award

PDN receives Green Impact Excellence Award

The Vice Chancellor has awarded our Department with the Green Impact Excellence Award for its commitment to waste reduction

PDN receives Green Impact Excellence Award - Read More…

A 3D cell shape that enables tube formation

A 3D cell shape that enables tube formation

New modelling and in vivo observations reveal that cells in tubes adopt an asymmetric cell shape dubbed scutoid, contrary to some previous assumptions

A 3D cell shape that enables tube formation - Read More…

How flat sheets of cells become tubular organs

How flat sheets of cells become tubular organs

New research by Guy Blanchard in collaboration with the LMB Cell Biology Division gives new insight into how flat layers of cell tissue develop into 3D structures

How flat sheets of cells become tubular organs - Read More…

Rapid Cue-Specific Remodeling of the Nascent Axonal Proteome

Rapid Cue-Specific Remodeling of the Nascent Axonal Proteome

The Holt lab at PDN has developed a new method to identify newly synthesized axonal proteins in response to axon guidance cues. Axons stimulated by different guidance cues show distinct and common signatures.

Rapid Cue-Specific Remodeling of the Nascent Axonal Proteome - Read More…

PDN scientists generate key life event in artificial mouse ‘embryo’ created from stem cells

PDN scientists generate key life event in artificial mouse ‘embryo’ created from stem cells

The creation of artificial embryos has moved a step forward after an international team lead by Magda Zernicka-Goetz used mouse stem cells to produce artificial embryo-like structures capable of ‘gastrulation’, a key step in the life of any embryo

PDN scientists generate key life event in artificial mouse ‘embryo’ created from stem cells - Read More…

Amanda Sferruzzi-Perri awarded Lister Prize Fellowship

Amanda Sferruzzi-Perri awarded Lister Prize Fellowship

The Lister Institute provides research funding to outstanding early career scientists whose work shows excellent potential to make an impact in the field of biomedical sciences

Amanda Sferruzzi-Perri awarded Lister Prize Fellowship - Read More…

Five members of Dino Giussani's group awarded prizes at international meeting

Five members of Dino Giussani's group awarded prizes at international meeting

Postdocs, PhDs and undergraduate members of Dino's group receive awards at the Society for Reproductive Investigation 65th Annual International Meeting

Five members of Dino Giussani's group awarded prizes at international meeting - Read More…

Prof Ewa Paluch awarded EMBO membership

Prof Ewa Paluch awarded EMBO membership

PDN's Director of Research among 62 newly selected member of European research organization

Prof Ewa Paluch awarded EMBO membership - Read More…

Wolfram Schultz awarded The 2018 Gruber Neuroscience Prize

Wolfram Schultz awarded The 2018 Gruber Neuroscience Prize

The PDN neuroscientist received the joint award for his work on the structure, organization and functions of the basal ganglia

Wolfram Schultz awarded The 2018 Gruber Neuroscience Prize - Read More…

The game of fate: tracing the origin of heterogeneity and symmetry breaking in the early mammalian embryo

The game of fate: tracing the origin of heterogeneity and symmetry breaking in the early mammalian embryo

New paper on Nature Communications by Magda Zernicka Goetz in collaboration with researchers from the University of Nevada digs into one of the central questions of developmental biology, single cell differentiation

The game of fate: tracing the origin of heterogeneity and symmetry breaking in the early mammalian embryo - Read More…

How muscle satellite-like cells remain undifferentiated

How muscle satellite-like cells remain undifferentiated

New study by Hadi Boukhatmi and Sarah Bray shows population of adult satellite-like cells in Drosophila maintained through a switch in RNA-isoforms

How muscle satellite-like cells remain undifferentiated - Read More…

Transcription factor HIF2a necessary for the development and function of the carotid body.

Transcription factor HIF2a necessary for the development and function of the carotid body.

Study by Randall Johnson's lab uses genetic and physiological analysis to demonstrate the essential role of the transcription factor HIF-2alpha in the sympathetic nervous system control of the ventilatory response to hypoxia

Transcription factor HIF2a necessary for the development and function of the carotid body. - Read More…

Mechanism behind neuron death in motor neurone disease and frontotemporal dementia discovered

Mechanism behind neuron death in motor neurone disease and frontotemporal dementia discovered

Scientists from Christine Holt lab in collaboration with the University of Toronto have identified the molecular mechanism that leads to the death of neurons in amyotrophic lateral sclerosis (also known as ALS or motor neurone disease) and a common form of frontotemporal dementia.

Mechanism behind neuron death in motor neurone disease and frontotemporal dementia discovered - Read More…

‘Sleeping’ stem cells could aid regenerative medicine for brain repair

‘Sleeping’ stem cells could aid regenerative medicine for brain repair

Scientists at the Wellcome Trust/ Cancer Research UK Gurdon Institute, University of Cambridge, have identified a new type of stem cell in the brain which they say has a high potential for repair following brain injury or disease.

‘Sleeping’ stem cells could aid regenerative medicine for brain repair - Read More…

New studies describe role of glutamate receptor ion channels in cancer progression

New studies describe role of glutamate receptor ion channels in cancer progression

Two studies published in Open Biology and Cancer Cell, co-authored by Hugh Robinson, have shed new light on how glutamate receptor ion channels are involved in cancer progression

New studies describe role of glutamate receptor ion channels in cancer progression - Read More…

Study shows how muscles regulate their oxygen consumption

Study shows how muscles regulate their oxygen consumption

A new study by Randall Johnson published in Cell Metabolism shows that an enzyme called FIH determines how muscles consume oxygen. Without the enzyme, the need for oxygen increases during physical exercise. The finding is of potential significance to elite athletes, who have been found to have higher levels of FIH in their muscles than others.

Study shows how muscles regulate their oxygen consumption - Read More…

Azim Surani to receive coveted Canada Gairdner International Award for discovery of genomic imprinting

Azim Surani to receive coveted Canada Gairdner International Award for discovery of genomic imprinting

Azim Surani of the Gurdon Institute and Davor Solter of the Max Planck Institute of Immunobiology and Epigenetics will receive Canada's top research award from the Gairdner Foundation in recognition of their work establishing the field of epigenetics with the discovery of genomic imprinting

Azim Surani to receive coveted Canada Gairdner International Award for discovery of genomic imprinting - Read More…

The world's highest lab is uncovering the secrets of extreme fitness

The world's highest lab is uncovering the secrets of extreme fitness

Andrew Murray, part of the Xtreme Everest project, was interviewed by Wired Magazine on the difficulties of testing Sherpas in high altitude, low oxygen environments

The world's highest lab is uncovering the secrets of extreme fitness - Read More…

Dr Matt Mason awarded 2018 Pilkington Prize

Dr Matt Mason awarded 2018 Pilkington Prize

The Pilkington Prize award acknowledges excellence in teaching at the University of Cambridge

Dr Matt Mason awarded 2018 Pilkington Prize - Read More…

How the brain tidies up memories during sleep

How the brain tidies up memories during sleep

Connections between brain cells are refined during sleep in a way that makes a memory stand out without interfering with previously stored memories, new study by Ole Paulsen's group shows

How the brain tidies up memories during sleep - Read More…