Research
In developed countries, more than 15% of women develop pregnancy complications which are associated with placental insufficiency and fetal and maternal morbidity and mortality. Such complications include fetal growth restriction, premature birth, gestational diabetes and preeclampsia. To better understand the aetiology of these pregnancy complications and developmental processes in a wider context, my laboratory has been investigating the environmental and genetic control of placental morphogenesis and function and its relevance for fetal development, maternal health and the long-term programming of disease. Our work combines novel genetic tools and established environmental models, with in vivo functional assays and cellular, histological and molecular techniques in vitro. We also use donated human biomaterial from women. The research aims of the lab are:
1) To better understand the molecular mechanisms governing placental trophoblast differentiation and function.
2) To examine how the placenta may influence the metabolic and cardiovascular systems of the mother and thus, her capacity to partition resources to the developing fetus.
3) To determine how the placenta senses and responds to the maternal environment and thereby regulates fetal growth and development.
4) To identify whether changes in maternal-fetal resource allocation due to altered placental function has consequences for the developmental and health programme of the offspring later in life.
Collaborators
Prof Abby Fowden
Dr Andrew Murray
Prof Dino Giussani
Dr Miguel Constancia, Dept of Obstetrics and Gynaecology, University of Cambridge
Prof Sue Ozanne, Institute of Metabolic Sciences, Cambridge
Dr David Williams, University College London
Prof Martha Lappas and Dr Padma Murthi, University of Melbourne
Prof Anna David, and Dr Sara Hillman, University College London
Prof Joris Vriens, KY Leuven
Dr Linus Shao, University of Gothenburg
Current and past funding
Royal Society
Academy of Medical Sciences
MRC
EU commission
Lister Institute of Preventative Medicine
Isaac Newton Trust
A*Star
Publications
Lopez-Tello J*, Yong HEJ, Sandovici I, Christoforou E, Salazar-Petres E, Boyland R, Napso T, Constancia M†, Sferruzzi-Perri AN† (2023) Fetal manipulation of maternal metabolism is a critical function of Igf2 imprinting. Available on bioRxiv and in press Cell Metabolism (CELL-METABOLISM-D-22-00333). * joint first author. † Joint senior author
Yong HEJ*, Maksym K*, Yusoff MAB, Salazar-Petres E, Nazarenko T, Zaikin A, David AL, Hillman SL†, Sferruzzi-Perri AN† (2023) Integrated placental modelling of histology with gene expression to identify functional impact in health and disease. Cells 12(7):1093 and medRxiv. * joint first author. † Joint senior author.
Musa E*, Salazar-Petres E*, Arowolo A, Levitt N, Matjila M*, Sferruzzi-Perri AN* 2023 Obesity and gestational diabetes independently and collectively, induce specific impacts on placental structure, inflammation, and endocrine function. Accepted in press Journal of Physiology doi: 10.1113/JP284139. A feature by the journal: https://physoc.onlinelibrary.wiley.com/doi/10.1113/JP284407 and much media attention (featured on 23 outlets): https://wiley.altmetric.com/details/142967245/news
Salazar-Petres E, Pereira-Carvalho D, Lopez-Tello†, Sferruzzi-Perri AN† (2023) Maternal and intrauterine influences on feto-placental growth are accompanied by sexually dimorphic changes in placental mitochondrial respiration, and metabolic signalling pathways. † Joint senior author. Cells 12:797 and on bioRxiv https://www.biorxiv.org/content/10.1101/2023.01.24.525377v1?rss=1
Lopez-Tello J and Sferruzzi-Perri AN (2023) Characterization of placental endocrine function and fetal brain development in a mouse model of small for gestational age. Frontiers in Endocrinology, 14:1116770
Candia AA, Jiménez T, Navarrete A, Beñaldo F, Silva P, Garcia-Herrera C, Sferruzzi-Perri AN, Krause BJ, González-Candia A, Herrera, EA (2023) Developmental ultrasound characteristics in guinea pigs: similarities with human pregnancy. J Vet Sci 10:144.
Sferruzzi-Perri AN, Lopez-Tello J, Salazar Petres E (2023) Invited review: Placental adaptations supporting fetal growth during normal and adverse gestational environments. Experimental Physiology 108:371-397
Pereira-Carvalho D, Salazar-Petres E, Lopez-Tello J*, Sferruzzi-Perri AN* (2022) Maternal and fetal PI3K-p110α deficiency induces sex-specific changes in conceptus growth and placental mitochondrial bioenergetic reserve in mice. Journal of Veterinary Science 13;9:501. On front page of journal: https://www.mdpi.com/journal/vetsci
Lean SC, Candia AA, Gulacsi E, Lee GCL, Sferruzzi-Perri AN (2022) Obesogenic high sugar and fat diet in mice compromises maternal metabolic physiology and lactation ability in association with maternal fat hyper-mobilisation and hepatic steatosis, and reductions in fetal growth and neonatal viability. Acta Physiologica 236:e13861. Much media attention e.g. https://mcginleysbar.com/western-style-diet-high-in-fat-and-sugar-can-ne....
Schroeder M*, Badini G, Sferruzzi-Perri AN*, Albrecht C* (2022) From placental development to health outcomes in middle-aged offspring: An update on the consequences of reproductive technologies. In press Frontiers in Cell and Developmental Biology. 10:906240. doi: 10.3389/fcell.2022.906240. *Contributed equally.
Cindrova-Davies, Sferruzzi-Perri AN* (2022) Human placental development and function. In press Seminars in Cell and Developmental Biology S1084-9521(22)00121-5. *Contributed equally
Lopez-Tello J, Salazar-Petres E, Webb L, Fowden AL, Sferruzzi-Perri AN (2022) Ablation of PI3K-p110alpha impairs maternal metabolic adaptations to pregnancy. Frontiers in Cell and Developmental Biology 10:928210
Lopez-Tello J, Jimenez-Martinez MA, Salazar-Petres E, Patel R, George AL, Kay RG, Sferruzzi-Perri AN (2022) Physiological changes in the mouse renal system in response to pregnancy. International Journal of Molecular Sciences 23, 6287
Lopez-Tello J*, Schofield Z*, Kiu R, Dalby MJ, van Sinderen S, Le Gall G, Sferruzzi-Perri AN, Hall LJ† (2021) Maternal microbiota Bifidobacterium promotes placental vascularization, nutrient transport and fetal growth in mice. Cell and Molecular Life Sciences 79:386 and Bioarchive server. † Joint senior author. Media attention: https://www.cam.ac.uk/research/news/maternal-microbiome-promotes-healthy-development-of-the-baby
Salazar-Petres E, Pereira Carvalho D, Lopez-Tello J, Sferruzzi-Perri AN (2022) Placental mitochondrial function, nutrient transporters, metabolic signalling and steroid metabolism relate to fetal size and sex in mice. Biology of Reproduction 106(6):1292-1311 and available on bioRxiv.
Napso T, Lean S, Lu M, Mort EJ, Desforges M, Moghimi, A, Bartels B, El-Bacha T, Fowden AL, Camm EJ*, Sferruzzi-Perri AN* (2022) Maternal obesity impacts feto-placental growth and induces sex-specific alterations in placental morphology, mitochondrial respiratory capacity, dynamics, lipid metabolism and oxidative stress. Acta Physiologica 234(4):e13795.
Pereira Carvalho D, Dias AF, Sferruzzi-Perri AN, Ortiga TM (2022) Gaps in the knowledge of thyroid hormones and placental biology. Biology of Reproduction, ioac006.
Aykroyd BRL, Tunster ST, Sferruzzi-Perri AN (2022) Loss of imprinting of the Igf2-H19 ICR1 enhances placental endocrine capacity via sex-specific alterations in signalling pathways in the mouse. Available on Bioarchive server and Development 149: dev199811. Featured as a Journal research highlight and Medicine Innovates Series
Sandovici I, Georgopoulou A, Perez-Garcia V, Hufnagel AS, López-Tello J, Lam BYH, Schiefer SN, Gaudreau C, Santos F, Hoelle K, Yeo GSH, Burling K, Reiterer M, Fowden AL, Burton GJ, Branco CM, Sferruzzi-Perri AN, Constância M (2022) The imprinted Igf2-Igf2r axis is critical for matching placental microvasculature expansion to fetal growth. Available on Bioarchive server and Developmental Cell 57(1):P63-79.E8W Covered by 10 media outlets around the world including, Science Daily
Hu M, Zhang Y, Ma S, Li J, Wang X, Liang M, Sferruzzi-Perri AN, Wu X, Ma H, Brännström M, Shao LR, Billig H (2021) Suppression of uterine and placental ferroptosis in a rat model of polycystic ovary syndrome by N-acetylcysteine. Molecular Human Reproduction 27 (12), gaab067.
Salazar-Petres E, Pereira Carvalho D, Lopez-Tello J, Sferruzzi-Perri AN (2021) Placental mitochondrial function, nutrient transporters, metabolic signalling and steroid metabolism relate to fetal size and sex in mice. Available on Bioarchive server
Lopez-Tello J*, Schofield Z*, Kiu R, Dalby MJ, van Sinderen S, Le Gall G, Sferruzzi-Perri AN†, Hall LJ† (2021) Maternal microbiota Bifidobacterium promotes placental vascularization, nutrient transport and fetal growth in mice. Available on Bioarchive server
Aykroyd BRL, Tunster ST, Sferruzzi-Perri AN (2021) Loss of imprinting of the Igf2-H19 ICR1 enhances placental endocrine capacity via sex-specific alterations in signalling pathways in the mouse. Available on Bioarchive server
Salazar Petres E and Sferruzzi-Perri AN (2021) Pregnancy-induced changes in β-cell function: who are the key players? In press J Physiology (doi: 10.1113/JP281082).
Siragher E and Sferruzzi-Perri AN (2021) The Hypoxic Placenta: What Have we Learnt from Small Animal Models of Maternal Inhalation Hypoxia? Placenta 113:29-47.
Rodgers A and Sferruzzi-Perri AN (2021) Developmental programming of offspring adipose tissue biology and obesity risk. Int J Obesity 45:1170-92.
Napso T, Zhao X, Ibañez Lligoña M, Sandovici I, Kay RG, Gribble FM, Reimann F, Meek CL, Hamilton RS, Sferruzzi-Perri AN (2021) Unbiased placental secretome characterization identifies candidates for pregnancy complications. Nature Communications Biology 4:701. Available of bioRxiv Covered by 43 media outlets around the world, including The Times
Shao LR, Zhang Y, Hu M, Yang F, Zhang Y, Ma S, Zhang D, Wang X, Sferruzzi-Perri AN, Wu X, Brännström M, Billig H (2021) Increased uterine androgen receptor protein abundance results in implantation and mitochondrial defects in pregnant rats with hyperandrogenism and insulin resistance. Journal of Molecular Medicine 99:1427-1446
Lopez-Tello J and Sferruzzi-Perri AN (2021) Fused placentas: Till birth do us part. Placenta 103:177-9.
Yao S, Lopez-Tello J, Sferruzzi-Perri AN (2021) Developmental programming of the female reproductive system - a review. Biology of Reproduction 104:745-770.
Sferruzzi-Perri AN (2021) Placenta mitochondria central to GDM pathogenesis? Journal of Physiology 599:1019-1020.
Lu and Sferruzzi-Perri. Placental mitochondrial function in response to gestational exposures. Placenta 113:29-47.
Colson A, Sonveaux P, Debiève F, Sferruzzi-Perri AN (2021) Adaptations of the human placenta to hypoxia: opportunities for interventions in fetal growth restriction. Human Reproduction Update 27:531-69.
Lopez-Tello J and Sferruzzi-Perri AN (2021) Fused placentas: Till birth do us part. Placenta 103: 177-9.
Zhang Y, Hu M, Jia W, Liu G, Zhang J, Wang B, Li J, Cui P, Li X, Lager S, Sferruzzi-Perri AN, Han Y, Liu S, Wu X, Brännström M, Linus Shao L, Billig H (2020) Hyperandrogenism and insulin resistance modulate gravid uterine and placental ferroptosis in PCOS-like rats. Journal of Endocrinology 246:247-263.
Christoforou ER and Sferruzzi-Perri AN (2020) Invited review: Molecular mechanisms governing offspring metabolic programming in rodent models of in utero stress. Cellular and Molecular Life Sciences 77:4861-4898.
Fowden AL, Camm EJ, Sferruzzi-Perri (2021) Invited review: Placental consequences of maternal obesity. Current Vascular Pharmacology 19:113-31.
Aykroyd BRL, Tunster ST, Sferruzzi-Perri AN (2020) Igf2 deletion alters mouse placenta endocrine capacity in a sexually-dimorphic manner. Journal of Endocrinology 246:93-108.
De Clercq K*, Lopez-Tello J, Vriens J, Sferruzzi-Perri AN (2020) Double-label immunohistochemistry to assess labyrinth structure of the mouse placenta with stereology. Placenta 94:44-47. * Contributed equally.
Kaitu’u-Lino TJ, MacDonald TM, Cannon P, Nguyen TV, Hiscock RJ, Haan N, Hastie R, Dane KM, Middleton AL, Bittar I, Sferruzzi-Perri AN, Pritchard N, Harper A, Hannan AJ, Kyritsis V, Crinis N, HuiL, Walker SP, Tong S (2020) Circulating SPINT1 is a marker of placental insufficiency and fetal growth restriction. Nature Communications 11:2411.
Sandovici I, Georgopoulou A, Perez-Garcia V, Hufnagel AS, López-Tello J, Lam BYH, Schiefer SN, Gaudreau C, Santos F, Hoelle K, Yeo GSH, Burling K, Reiterer M, Fowden AL, Burton GJ, Branco CM, Sferruzzi-Perri AN, Constância M (2019) The Imprinted Igf2-Igf2r Axis is Critical for Matching Placental Microvasculature Expansion to Fetal Growth. Available on bioRxiv: https://www.biorxiv.org/content/10.1101/520536v3
Napso T, Hung Y-P, Davidge S, Care A, Sferruzzi-Perri AN (2019) Advanced maternal age compromises fetal growth and induces sex-specific changes in placental phenotype in rats. Scientific Reports 9:16916.
Sferruzzi-Perri AN, López-Tello J, Napso T, Yong HE. Invited review: Exploring the causes and consequences of maternal metabolic maladaptations during pregnancy. Placenta 98:43-51.
López-Tello J, Arias-Álvarez M, González-Bulnes A, Sferruzzi-Perri AN (2019) Rabbit models for studying intrauterine growth restriction and fetal programming. Molecular Reproduction & Development 86:1781-1809.
Musial B, Fernandez-Twinn, Duque-Guimaraes D, Carr SK, Fowden AL, Ozanne SE*, Sferruzzi-Perri AN* (2019) Exercise alters the molecular pathways of insulin signalling and lipid handling in maternal tissues of obese pregnant mice. Physiological Reports 7(16):e14202.
Lopez-Tello J, Perez-Garcia V, Khaira J, Kusinski L, Andreani, A, Grant I, Fernandez De Liger E, Cooper W, Hemberger M, Sandovici I, Constancia M, Sferruzzi-Perri AN (2019) Interplay between fetal and trophoblast phosphoinositol 3-kinase (PI3K) p110α signalling modifies resource allocation to the growing fetus. eLIFE 8: e45282.
Lee CQR, Bailey A, Lopez-Tello J, Sferruzzi-Perri AN, Okkenhaug K, Moffett A, Hemberger M, Rossant J (2019) Inhibition of phosphatidylinositol-3-kinase signaling promotes the stem cell state of trophoblast. Stem Cells 37:1307-1318
Zhang Y, Zhao W, Xu H, Hu M, Guo X, Jia W, Liu G, Li J, Cui P, Lager SM, Sferruzzi-Perri AN, Li W, Wu X, Brännström M, Shao LR, Billig H (2019) Mechanisms of PCOS-induced fetal loss: evidence for placental mitochondrial abnormalities and elevated ROS production in PCOS-like pregnant rats. Journal of Physiology 597:3927-3950.
Sandovici I, Georgopoulou A, Hufnagel AS, Schiefer SN, Santos F, Hoelle K, Lam BYH, Yeo GSH, Burling K, López-Tello J, Reiterer M, Fowden AL, Burton GJ, Sferruzzi-Perri AN, Branco CM, Constância M (2019) Fetus-derived IGF2 matches placental development to fetal demand. Available on bioRxiv: https://www.biorxiv.org/content/early/2019/01/16/520536
De Clercq K, Persoons E, Napso T, Luyten C, Parac-Vogt TN, Sferruzzi-Perri AN, Kerckhofs G and Vriens J (2019) Simultaneous 3D morphological analysis of the mature murine placenta and its vasculature using contrast enhanced microCT. PNAS 116:13927-13936.
Hu M, Zhang Y, Guo X, Jia W, Liu G, Zhang J, Li J, Cui P, Sferruzzi-Perri AN, Han Y, Wu X, Ma H, Brännström M, Shao LR and Billig H (2019) Hyperandrogenism and insulin resistance induce gravid uterine defects in association with mitochondrial dysfunction and aberrant ROS production. American Journal of Physiology Endocrinology and Metabolism 316:E794-E809.
Sferruzzi-Perri AN, Higgins J, Vaughan OR, Murray AJ, Fowden AL (2019) Placental mitochondria adapt developmentally and in response to hypoxia to support fetal growth. PNAS 116(5):1621-1626.
Lopez-Tello J, Jimenez-Martinez MA. Herrera E, Krause B*, Sferruzzi-Perri AN* (2018) Progressive uterine artery occlusion in the guinea pig leads to defects in placental structure that relate to fetal growth. Placenta 72-73:36-40. *joint last author.
Napso T*, Yong HEJ*, Lopez-Tello J, Sferruzzi-Perri AN (2018). The role of placental hormones in mediating maternal adaptations to support pregnancy and lactation. Frontiers in Physiology. 9:1091. *Joint first author.
Camm EJ, Botting KJ, Sferruzzi-Perri AN Near to one’s heart: the intimate relationship between the placenta and fetal heart. Invited Review. Frontiers in Physiology 9:629.
Nuzzo AM*, Camm EJ*, Sferruzzi-Perri AN, Ashmore TJ, Yung HW, Spiroski AM, Sutherland MR, Logan A, Austin-Williams S, Burton GJ, Rolfo A, Todros T, Murphy MP, Giussani DA (2018) Placental adaptation to early-onset hypoxic pregnancy and mitochondria-targeted antioxidant therapy in the rat. American Journal of Pathology 188:2704-2716. *joint first author.
Balmas E, Rana B, Hamilton RS, Shreeve N, Kieckbusch J, Aye I, Hawkes DA, Trotter S, López-Tello J, Yong H, Valenti S, Sferruzzi-Perri AN, Gaccioli F, McKenzie ANJ, Colucci F (2018) Maternal group 2 innate lymphoid cells control fetal growth and protect from endotoxin-induced abortion in mice. Available online on bioRxiv: http://biorxiv.org/cgi/content/short/348755v1
Sferruzzi-Perri AN (2018) Balancing needs; Exploring the role of IGF2 signalling in materno-fetal resource allocation. Invited Review. Placenta, 64 Suppl 1:S16-S22.
Sferruzzi-Perri AN Assessment of placental transport function in studies of disease programming (2018). Invited Review. Methods in Molecular Biology, 1735:239-250.
Kwok A, Zvetkova I, Virtue S, Huang-Doran I, Tomlinson P, Bulger A, Hart D, Knox R, Franks S, Voschol P, Vidal-Puig A, Sferruzzi-Perri AN, Jensen J, O’Rahilly S, Semple R (2017) C-terminal truncation of Pik3r1 in mice models human lipodystrophic insulin resistance uncoupled from dyslipidemia. Available online on bioRxiv: https://www.biorxiv.org/content/early/2017/11/24/224485.
Decato BE, Lopez-Tello J, Sferruzzi-Perri AN, Smith AD, Dean MD (2017) DNA methylation divergence and tissue specialization in the developing mouse placenta, Molecular Biology and Evolution, 34(7):1702-1712.
Musial B, Vaughan OR, Ozanne SE, Fowden AL, Sferruzzi-Perri AN (2017) A diet high in sugar and fat causes glucose intolerance and fat deposition in the mother with consequences for feto-placental growth in mice, Journal of Physiology, 595(14):4875-4892.
Sferruzzi-Perri AN, Sandovici I, Constancia M, Fowden AL (2017) Placental phenotype and the insulin-like growth factors: resource allocation to fetal growth. Invited review, Journal of Physiology, 595(15):5057-5093
Fernandez-Twinn D, Gascoin G, Musial B, Carr S, Duque-Guimaraes D, Blackmore H, Zahra M Alfaradhi, Loche E, Ferland-McCollough D, Bushell M, Sferruzzi-Perri AN, Fowden AL, Ozanne SE (2017) Exercise rescues obese mothers' insulin sensitivity, placental function and her offsprings' insulin sensitivity, Scientific Reports, 7:44650.
Nadkarni S,Smith J, Machado I,Sferruzzi-Perri AN, Kishore M Hass R, Mauro C, Williams D, Farsky S, Marelli-Berg F, Perretti M (2017) Neutrophils induce pro-angiogenic T cells with a regulatory phenotype in pregnancy, PNAS, 113(52):E8415-E8424.
Sferruzzi-Perri AN, Lopez-Tello J, Fowden AL, Constancia M (2016) Maternal and fetal genomes interplay through phosphoinositol 3-kinase(PI3K)-p110α signaling to modify placental resource allocation, PNAS, 113(40):11255-11260.
Sferruzzi-Perri AN, Camm EJ (2016) The programming power of the placenta, Frontiers in Physiology, 7:33.
Boulenouar B*, Doisne J-M*, Sferruzzi-Perri AN, Gaynor L, Kieckbusch J, Balmas E, Yung HW, Javadzadeh S, Volmer L, Hawkes DA, Phillips K, Brady H, Fowden AL, Burton GJ, Moffett A, Colucci F (2015) NFIL3-dependent natural killer cells mediate maternal adaptations to pregnancy, placental development and fetal growth, Frontiers in Immunology, 7:43* joint first author.
Musial B, Fernandez-Twinn, Vaughan OR, Ozanne SE, Voshol P, Sferruzzi-Perri AN, Fowden AL (2015) Proximity to delivery alters insulin sensitivity and glucose metabolism in pregnant mice, Diabetes, Jan 6. pii: db151531.
Higgins JS, Vaughan OR, Fernandez De Liger E, Fowden AL, Sferruzzi-Perri AN (2015) Placental phenotype and resource allocation to fetal growth are modified by the timing and degree of hypoxia during mouse pregnancy, Journal of Physiology, 594:1341-56.
Ito M, Sferruzzi-Perri AN, Edwards CA, Adalsteinsson BT, Allen SE, Loo TH, Kitazawa M, Kaneko-Ishino T, Ishino F, Stewart CL, Ferguson-Smith AC (2015) A trans-homologue interaction between reciprocally imprinted miR-127 and Rtl1 regulates placenta development, Development, 142:2425-30.
Standen P, Sferruzzi-Perri AN, Taylor R, Heinemann G, Zhang JV, Highet AR, Pringle KG, Owens JA, Kumarasamy V, Lumbers ER, Roberts CT (2015) Maternal insulin-like growth factor 1 and 2 differentially affect the renin-angiotensin system during pregnancy in the guinea pig, Growth Hormone and IGF Research, 25:141-7.
Skeffington KL, Higgins JS, Mahmoud AD, Evans AM, Sferruzzi-Perri AN, Fowden AL, Yung HW, Burton GJ, Giussani DA, Moore LG (2015) Hypoxia, AMPK activation and uterine artery vasoreactivity, Journal of Physiology, 594:1105-11.
Vaughan OR, Fisher HM, Dionelis KN, Jefferies EC, Higgins JS, Musial B, Sferruzzi-Perri AN, Fowden AL (2015) Corticosterone alters materno-fetal glucose partitioning and insulin signalling in pregnant mice, Journal of Physiology, 593:1307-21.
Fowden AL, Forhead AJ, Sferruzzi-Perri AN, Burton GJ, Vaughan OR (2014) Endocrine regulation of placental phenotype, Placenta, Suppl 1:S50-9.
Sferruzzi-Perri AN, Vaughan OR, Haro M, Cooper WN, Musial B, Charalambous M, Pestana D, Ayyar S, Ferguson-Smith AC, Burton GJ, Constancia M, Fowden AL (2013) An Obesogenic Diet Modifies nutrient partitioning and fetal Growth Trajectory, FASEB Journal, 27(10):3928-37.
Sferruzzi-Perri AN, Vaughan OR, Forhead AJ, Fowden AL (2013) Hormonal and nutritional drivers of intrauterine growth, Current Opinion in Clinical Nutrition & Metabolic Care, 16(3):298-309.
Sferruzzi-Perri AN, Owens JA, Pringle KG, Roberts CT (2011) The neglected role of maternal endocrine insulin-like growth factors in regulating fetal growth, Invited Review, Journal of Physiology, 589(Pt 1):7-20.
Sferruzzi-Perri AN, Vaughan OR, Coan PM, Suciu MC, Darbyshire R, Constancia M, Burton GJ, Fowden AL (2011) Placental-specific Igf2 deficiency alters developmental adaptations to undernutrition in mice, Endocrinology, 52:3202-12.
Teaching and Supervisions
Co-organiser of the Part II Course
Senior examiner and demonstrator for Part 1B Human Reproduction
Lecturer for the Placental Biology Course, Centre for Trophoblast Research
Co-organiser MPhil in Biological Sciences - Reproduction & Embryology
Tutor, St John's College
