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Department of Physiology, Development and Neuroscience

Studying at Cambridge

Talks at PDN

Mon 02 Dec 16:30: The axonal cytoskeleton at the nanoscale

From Adrian Seminars in Neuroscience. Published on Oct 07, 2019.

The axonal cytoskeleton at the nanoscale

The intricate morphology and molecular identity of axons is maintained for decades, but also continuously adapts to changes in the environment and activity of neurons. Axons fulfill these paradoxical demands thanks to a unique cytoskeletal organization that ensures the coordinated transport, anchoring and mobility of axonal components. In our lab, we use super-resolution microscopy to map the nanoscale architecture actin-based structures within the axon. In the axon initial segment, a key compartment for the maintenance of neuronal polarity, we resolved a highly organized assembly encompassing the periodic actin/spectrin scaffold and its partners: ankyrin, myosins. We have also visualized new actin structures along the axon shaft: rings, hotspots and trails, and are now exploring their molecular organization and functions. For this, we develop a combination of versatile labeling, correlative live-cell/super-resolution/electron microscopy and quantitative analysis that allow for high-content, nanoscale interrogation of the axonal architecture.

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Thu 07 Nov 16:00: The amazing world of the GnRH neuron

From Foster Talks. Published on Oct 04, 2019.

The amazing world of the GnRH neuron

Abstract not available

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Thu 16 Jan 16:00: Mechanics of epithelial migration, growth and folding

From Foster Talks. Published on Oct 04, 2019.

Mechanics of epithelial migration, growth and folding

Abstract not available

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Thu 12 Mar 16:00: 3D Genomics in development and disease

From Foster Talks. Published on Oct 04, 2019.

3D Genomics in development and disease

Abstract not available

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Thu 07 May 16:00: Mechanisms of lineage specification in human embryos

From Foster Talks. Published on Oct 04, 2019.

Mechanisms of lineage specification in human embryos

Abstract not available

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Thu 14 May 16:00: Mechanobiology of cell shape control

From Foster Talks. Published on Oct 04, 2019.

Mechanobiology of cell shape control

Abstract not available

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Mon 09 Dec 16:30: Blood is thicker than water

From Adrian Seminars in Neuroscience. Published on Oct 04, 2019.

Blood is thicker than water

Abstract not available

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Mon 28 Oct 16:30: Synapse specific homeostatic responses to sensory deprivation

From Adrian Seminars in Neuroscience. Published on Oct 04, 2019.

Synapse specific homeostatic responses to sensory deprivation

Abstract not available

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