John Rogers PhD
University Lecturer Tel: +44 (0)1223 333865, Fax: +44 (0)1223 333840, E-mail: jhr11@cam.ac.uk
Research Interests
Neural injury and regeneration. Genetic manipulation promoting axon regeneration. Responses of the mammalian CNS to injury. Viral vectors for repairing damaged neurones.
This research aims to promote axon regeneration in the injured brain and spinal cord. We are working to express enzymes in herpes virus vectors, for expression in tissue culture and in neurons of rat brain or spinal cord.
Although it might be possible to do a Ph.D. project in this area, the student would almost certainly have to find their own funding.
I am also Jupiter Section Director in the British Astronomical Association.
Publications
Wilby MJ, Sinclair SR, Muir EM, Zietlow R, Adcock KH, Horellou P, Rogers JH, Dunnett SB & Fawcett JW (1999). A GDNF-secreting clone of the Schwann cell line SCTM41 enhances survival and fibre outgrowth from embryonic nigral neurons grafted to the striatum and the lesioned substantia nigra. J. Neurosci. 19, 2301-2312.
Fidler PS, Schuette K, Asher RA, Dobbertin A, Thornton SR, Calle-Patino Y, Muir EM, Levine JM, Geller HM, Rogers JH, Faissner A & Fawcett JW (1999). Comparing astrocytic cell lines that are inhibitory or permissive to axon growth: the major axon-inhibitory proteoglycan is NG2. J. Neurosci. 19, 8778-8788.
Rogers J, Ciossek T, Menzel P & Pasquale E (1999). Eph receptors and ephrins demarcate cerebellar lobules before and during their formation. Mechanisms of Development 87, 119-128.
Rogers J, Ciossek T, Ullrich A, West E , Hoare M & Muir EM (1999). Distribution of the receptor EphA7 and its ligands in development of the mouse nervous system. Molecular Brain Research 74, 225-230.
Muir EM, Adcock KH, Morgenstern DA, Clayton R, von Stillfried N, Rhodes K, Ellis C, Fawcett JW, Rogers JH (2002). Matrix metalloproteases and their inhibitors are produced by overlapping populations of activated astrocytes. Molecular Brain Research 100, 103-117.
Rogers JH, Rhodes K, Roberts R, Raza M, Muir EM, Fawcett JW, Scarpini CG, and Efstathiou S (2003). A herpesvirus vector can transduce axotomized brain neurons. Exp. Neurol. 183, 548-558.
How to recognise J.H.R.
Neurons in tissue culture (green) expressing beta-galactosidase (red).
Ganglia
in tissue culture in which many neurons are expressing beta-galactosidase
(blue).
Neurons in adult rat brain, in the parabrachial nucleus, expressing c-Jun (green) as a result of experimental axotomy, and beta-galactosidase (red).