Roger Hardie FRS
Roger C Hardie publications (with Pubmed/Journal links)
Articles
Satoh, A., Xia, H., Yan, L Hardie, R.C., Ready, DF. (2010) Arrestin translocation is stoichiometric to rhodopsin isomerization and accelerated by phototransduction in Drosophila photoreceptors Neuron 67, 997-1008 ref
Fain, G; Hardie, R.C., Laughlin, S.B. (2010) Phototransduction and the evolution of photoreceptors. Curr. Biol., 20, R114-124 ref
Mecklenburg, K.L., Takemori, N., Komori, N., Chu, B., Hardie, R.C., Matsumoto, H., and O'Tousa, J.E. (2010) Retinophilin Is a Light-Regulated Phosphoprotein Required to Suppress Photoreceptor Dark Noise in Drosophila. J. Neurosci. 30, 1238-1249.ref
Huang, J, Liu, C-H, Hughes, S.A, Postma, M, Schwiening, C Hardie.R.C. Activation of TRP channels by protons and phosphoinositide depletion and in Drosophila photoreceptors. (2010) Cur Biol 20,189-197 ref
Yau, K-W, Hardie, R.C (2009) Phototransduction Motifs in Vertebrates and Invertebrates Cell 139,246-264 ref
Hardie, R.C., Muallem, S Lipids in Ca2+ signalling - An Introduction. (2009) Cell Calcium 45,517-520 ref
Raghu, P., Hardie, R.C. Regulation of Drosophila TRPC channels by lipid messengers. (2009) Cell Calcium 45, 566-573 ref
Yusein,S., Velikova, N., Kupenova,P.,Hardie,R., Wolstenholme A and Semenov, E (2008) Altered ivermectin pharmacology and defective visual system in Drosophila mutants for histamine receptor HCLB. Invert Neurosc 8,211-222
Liu, C.-H., Satoh, A.K., Postma, M., Huang, J., Ready, D.F., and Hardie, R.C. (2008.). Ca2+ dependent metarhodopsin inactivation mediated by calmodulin and NINAC myosin III. Neuron 59 778-789 ref
Krause, S., Krause, Y., Liu, C.-H., Huang, J., Hardie, R.C., and Weckstrom, M. (2008). Light-dependent modulation of Shab channels via phosphoinositide depletion in Drosophila photoreceptors. Neuron 59, 596-607. ref
Pantazis, A., Segaran, A., Liu, C.H., Nikolaev, A., Rister, J., Thum, A., Semenov, E., Juusola, M., and Hardie, R.C. (2008). Distinct roles for two histamine receptors (hclA and hclB) at the Drosophila photoreceptor synapse. J Neurosci. 28:7250-7259 ref
Hardie, R.C. (2007). Vision: dynamic platforms. Nature 450, 37-39.
Hardie, R.C., and Postma, M. (2007). Phototransduction in microvillar photoreceptors of Drosophila and other invertebrates. In The Senses - a comprehensive reference Vision Volume 1 (eds. Albright, Masland) pp. 77-130, K. Basbaum, Shepher, Westheimer., ed. (Oxford: Academic Press).
Liu, C-H, Wang, T, Postma, M, Obukhov, AG, Montell, C & Hardie, RC (2007). In vivo identification and manipulation of the Ca2+ selectivity filter in the Drosophila TRP channel. J. Neurosci. 27 604-615 ref
Hardie, RC (2006). TRP channels and lipids: from Drosophila to mammalian physiology. J Physiol Lond. 578 9-25 ref
Hardie, R.C. Phototransduction in Invertebrate Photoreceptors (2006) In: Invertebrate Vision eds Warrant E, Nillson, D-E. C.U.P. pp.43-80
M. Vähäsöyrinki, J. E. Niven, R. C. Hardie, M. Weckström & M. Juusola Robustness of Neural Coding in Drosophila Photoreceptors in the Absence of Slow Delayed Rectifier K+ Channels. (2006) J Neurosci. 26:2652-2660 ref
Zheng, L.,Polaveja, G.G, Wolfram, V., Asyali, M.H., Hardie, R.C. & Juusola, M. (2006) Adaptation and feedback regulation in the first visual synapse of in vivo Drosophila. J. Gen Physiol. 127, 495-510ref
Rosenbaum E, Hardie RC and Colley NJ Calnexin is Essential for Rhodopsin Maturation, Calcium Homeostasis and Photoreceptor Cell Survival (2006). Neuron 49 229-241 ref
Hardie R.C. (2005) Inhibition of phospholipase C activity in Drosophila photoreceptors by BAPTA and di-bromo-BAPTA. Cell Calcium 38,547-556 ref
Gu, Y, Oberwinkler, J, Postma, M., Hardie, R.C. (2005) Mechanisms of light adaptation in Drosophila photoreceptors. Current Biology 15,1228-1234 ref
Georgiev P, Garcia-Murillas I, Ulahannan D, Hardie RC and Raghu P (2005) Functional INAD complexes are required to mediate degeneration in photoreceptors of the Drosophila rdgA mutant. J Cell Science 118; 1373-1384 ref
MacPherson, M.R., Pollock, V.P, Kean, L, Southall T.D., Giannakou,M.E., Broderick,K.E,, Dow,J.A.T.,. Hardie, R.C and Davies,S.A. (2005) Transient receptor potential-like (TRPL) channels are essential for calcium signalling and fluid transport in a Drosophila epithelium. Genetics 169:1541-1552 ref
Wang,T., Xu H, Oberwinkler, J, Gu, Y,Hardie, R.C. (2005) and Montell, C. Light-Activation, Adaptation and Cell Survival Functions of the Na+/Ca2+ Exchanger, CalX. Neuron 45:367-378 ref
Hardie, RC, Gu, Y Martin, F., Sweeney, S., Raghu P (2004) In vivo light induced and basal phospholipase C measured with genetically targeted PIP2 sensitive ion channels (Kir.21). J Biol Chem 279, 47773-47782. erf
Hardie, R.C. (2004) Regulation of Drosophila TRP channels by lipid messengers. In: Mammalian TRP channels as molecular targets. (Novartis Foundation Symposium). pp. 160-171 Wiley Chichester
Niven, J.E., M. Vahasoyrinki, M. Kauranen, R.C. Hardie, M. Juusola, and M. Weckstrom. (2003). The contribution of Shaker K+ channels to the information capacity of Drosophila photoreceptors. Nature. 421:630-4. ref
Hardie, R.C., F. Martin, S. Chyb, and P. Raghu. (2003). Rescue of Light Responses in the Drosophila "Null" Phospholipase C Mutant, norpAP24, by the Diacylglycerol Kinase Mutant, rdgA, and by Metabolic Inhibition. J. Biol. Chem. 278:18851-18858. ref
Hardie, R.C. (2003). TRP channels in Drosophila photoreceptors: the lipid connection. Cell Calcium. 33:385-393. ref
Hardie, R.C. (2003). Regulation of TRP channels via lipid second messengers. Annu Rev Physiol. 65:735-59. ref
Hardie, R.C. (2003). Phototransduction: shedding light on translocation. Curr Biol. 13:R775-7.
Hardie, R.C. et al (2002) Molecular basis of amplification in Drosophila phototransduction: roles for G protein, phospholipase C and diacylglycerol kinase. Neuron, 36,689-701 ref
Geng, C. Leung H-T, Skingsley DR, Iovchev, MI ZhanYin, Semenov EP, Burg MG, Hardie RC, Pak WL. (2002) Target of Drosophila Photoreceptor Synaptic Transmission is Histamine-Gated Chloride Channel Encoded by ort (hclA). J. Biol Chem 277,42113-42120 ref
Hardie R.C. (2002) Adaptation through translocation. Neuron (preview) 34, 3-5.
Hardie R.C. (2001) Phototransduction in Drosophila. J. Exp . Biol. 204:3403-3409 ref
Hardie, R.C. & Raghu, P. (2001) Visual transduction in Drosophila. Nature 41:186-193 ref
Polyanovsky, A., Zierold, K., Hardie, R.C. Gribakin, F.. Electrolyte distribution in Drosophila ommatidium as revealed by electron probe X-ray microanalysis. In prep.
Hardie, R.C., Raghu, P. , Moore, S. Juusola, M. Baines R.A & Sean T. Sweeney (2001) Calcium influx via TRP channels is required to maintain PIP2 levels in Drosophila photoreceptors. Neuron 30 149-159 ref
Juusola M, Hardie RC (2001) Light-Adaptation in Drosophila Photoreceptors: II Rising temperature increases the bandwidth of reliable signalling J Gen Physiol. 2000 117: 27-42. ref
Juusola M, Hardie RC (2001) Light-Adaptation in Drosophila Photoreceptors: I. Response dynamics and signaling efficiency at 25oC J Gen Physiol. 2000 117: 3-25. ref
Raghu,P , Colley N, Hasan, G, Selinger Z, &. Hardie RC (2000) Normal phototransduction in Drosophila photoreceptors lacking an InsP3 receptor gene. Mol. Cell Neurosci. 15: 429-445. ref
Raghu, P. Usher, K., Jonas, S.,Chyb, S, Polyanovsky, A, Hardie RC (2000). Constitutive activity of the light-sensitive channels TRP and TRPL in Drosophila diacylglycerol kinase mutant, retinal degeneration A (rdgA). Neuron 26:169-179 ref
Henderson, SR, Reuss H, Hardie RC (2000) Single photon responses in Drosophila photoreceptors and their regulation by Ca2+. J. Physiol. 524, 179-194 ref
Minke B, Hardie R.C Genetic dissection of phototransduction in Drosophila. (2000) Handbook of Biological Physics, Vol 3: Primary Visual Processes (D.G Stavenga, W.J. de Grip, Pugh EJ Jr. eds.). Elsevier (pp 449-525).
Polyanovskii, A.D., Hardie, R.C. & Krause, K.H. The TRP protein in Drosophila photoreceptors: An immunogold localization of the light-sensitive calcium-permeable channel. J Evol Biochem Physiol 35, 669-680 (1999).
Chyb,S, Hevers W, Forte M, Wolfgang WJ, Selinger Z, Hardie, RC (1999) Modulation of the light response by cAMP in Drosophila photoreceptors. J . Neurosci. 1999 19: 8799-8807 ref
Chyb S, Raghu, P., Hardie.R.C. (1999) Poly-unsaturated fatty acids activate the Drosophila light-sensitive channels TRP and TRPL. Nature 397:255-259 ref
Hardie, R.C., Raghu, P (1998) Activation of heterologously expressed Drosophila TRPL channels: Ca2+ is not required, InsP3 is not sufficient. Cell Calcium 24:153-163. ref
Yagodin, S., Hardie, R.C, Millar, N, Mason, W., & Sattelle DB (1998). Thapsigargin and receptor-mediated activation of Drosophila TRPL channels expressed in a Drosophila S2 cell line Cell Calcium 23:219
Reuss H., Mojet, M., Chyb, S. & Hardie R.C (1997) In vivo analysis of the Drosophila light-sensitive channels TRP and TRPL Neuron 19: 1249-1259 ref
Hardie R.C., Reuss H., Lansdell, S.J. & Millar, N.S. (1997) Functional equivalence of native light-sensitive channels in the Drosophila trp301 mutant and TRPL cation channels expressed in a stable cell line. Cell Calcium. 21: 431-440. ref
Hardie RC (1997b) Excitation in Drosophila photoreceptors. . Cloe Taddei-Ferretti and Carlo Musio, eds.,"From Structure to Information in Sensory Systems", World Scientific, Singapore, New Jersey, London, Hong Kong, 1997.
Hardie RC (1997a) Properties of light-sensitive channels in Drosophila photoreceptors. Cloe Taddei-Ferretti and Carlo Musio, eds.,"From Structure to Information in Sensory Systems", World Scientific, Singapore, New Jersey, London, Hong Kong, 1997.
Hardie R.C. (1996) Setting store by Calcium. Current Biology. 6: 1371-1373.
Hofstee, CA, Henderson S, Hardie RC, Stavenga DG (1996) Differential effects of calmodulin binding proteins (p132 and p174) on pigment migration and light-activated currents in Drosophila photoreceptors. Visual Neurosci. 13:987-906. ref
Hardie RC (1996c) Excitation of Drosophila photoreceptors by BAPTA and ionomycin: evidence for capacitative Ca2+ entry? Cell Calcium 20:315-327. ref
Hardie RC (1996b) A quantitative estimate of the maximum amount of light-induced Ca2+ release in Drosophila photoreceptors. J Photochem Photobiol. 35; 83-89. ref
Hardie RC (1996a) INDO-1 measurements of resting and light-induced cytosolic Ca in Drosophila photoreceptors. J Neurosci. 16:2924-2933 ref
Anderson J, Hardie RC (1996). Different photoreceptors in the same retina contain unique complements of K channels. J Comp Physiol. 178,513-422
Hardie RC, Minke B (1995) Phosphoinositide-mediated phototransduction in fly photoreceptors: the role of Ca2+ and TRP. Cell Calcium 16:256-274 ref
Hardie RC, Mojet MH (1995) Magnesium dependent block of the light-activated- and trp-dependent conductance in Drosophila photoreceptors. (J Neurophysiol.74:2590-2599)
Hardie RC (1995b) Effects of intracellular Ca2+ chelation on the light response in Drosophila photoreceptors. J Comp Physiol A 177: 707-721. ref
Pollock JA, Assaf A, Peretz A, Nichols CD, Mojet MH, Hardie RC, Minke B (1995) TRP a protein essential for inositide-mediated Ca2+ influx is localized adjacent to the calcium stores in Drosophila photoreceptors. J Neurosci. 15:3747-3760.
Skingsley DR, Laughlin SB, Hardie RC (1995) Properties of histamine-activated chloride channels in the large monopolar cells (LMCs) of the dipteran compound eye: a comparative study. J comp Physiol 176:611-623
Hevers W, Hardie RC (1995) Serotonin modulates the voltage dependence of Shaker potassium channels in Drosophila photoreceptors Neuron 14: 845-856 ref
Cuttle M, Hevers W, Laughlin, SB, Hardie RC (1995) Diurnal modulation of potassium conductance in locust photoreceptors. J comp Physiol A 176:307-316
Hardie, R.C. (1995a) Caged Ca2+ facilitates and inactivates but does not directly excite light sensitive channels in Drosophila photoreceptors. J Neurosci. 15:889-902 ref
Peretz, A., Sandler, C., Kirschfeld, K.,Hardie R.C., and Minke, B. (1994) Genetic dissection of light-induced Ca2+ influx into Drosophila photoreceptors. J. gen. Physiol. 104:1-57-1078 ref
Hardie, R.C., and Minke, B (1994) Ca2+-dependent inactivation of light-sensitive channels in Drosophila photoreceptors. J. gen. Physiol.103:409-427 ref
Hardie, R.C., and Minke, B (1994) Spontaneous activation of light-sensitive channels in Drosophila photoreceptors. J. gen. Physiol.103:389-407
Hardie , R.C. (1993) Phototransduction: the invertebrate enigma. News & Views Nature 366:113-114
Hardie, R.C., and Minke, B (1993) Novel Ca2+ channels underlying transduction in Drosophila photoreceptors: implications for phosphoinositide-mediated Ca2+ mobilization. Trends Neurosci. 16:371-376. ref
Hardie, R.C. & Minke, B. (1993) Phototransduction in Drosophila. In: Sensory systems of arthropods (Wiese K, Gribakin FG, Popov AV & Renninger G eds) pp. 3-12 Birkhauser Verlag Basel Boston Berlin
Hardie, R.C., Suss-Toby, E., Peretz, A., Rom-Glas, A., Selinger, Z. & Minke, B (1993) Protein kinase C is required for light adaptation in Drosophila photoreceptors. Nature 363, 634-637. ref
Hardie R.C., Pollock J.A, Peretz, A. & Minke B (1993) Ca2+ limits the development of the light response in Drosophila photoreceptors. Proc Roy Soc Lond B 252:223-229. ref
Hardie, R.C. Minke, B. (1992) Light-activated channels in Drosophila are coded by the trp gene. In: Structures and functions of retinal proteins. Ed. J.L Rigaud. Colloque INSERM/ John Libbey Eurotext Ltd Vol 221:403-406.
Hardie RC, Minke B. (1992) The trp gene is essential for a light-activated Ca channel in Drosophila photoreceptors. Neuron 8,643-651. ref
Hardie RC (1991b) Voltage sensitive potassium channels in Drosophila photoreceptors. J. Neurosci. 11:3079- 3095 ref
Hardie RC (1991a) Whole-cell recordings of the light-induced current in Drosophila photoreceptors: evidence for feedback by calcium permeating the light sensitive channels. Proc Roy Soc Lond B. 245:203-210
Weckström M, Hardie, RC & Laughlin SB (1991). Voltage-activated potassium channels in blowfly photoreceptors and their role in light-adaptation. J. Physiol. Lond 440:635-657 ref
Hardie, RC, Voss D, Pongs O & Laughlin SB (1991) Novel potassium channels encoded by the Shaker locus in Drosophila photoreceptors. Neuron 6:477-486 ref
Hardie R.C & Weckström, M. (1990) Three classes of potassium channels in identified non-spiking visual interneurones from the blowfly Calliphora vicina. J. comp. Physiol. 167: 723-736
Hardie, R.C. (1989) A histamine-gated chloride channel involved in synaptic transmission at a photoreceptor synapse. Nature,339:704-706 ref
Hardie, R.C., Laughlin, S.B., Osorio, D-C. (1989). Early visual processing in the compound eye: physiology and pharmacology of the retina-lamina projection in the fly. In: Neurobiology of sensory systems. Singh N, Strausfeld NJ eds. pp. 23-42 Plenum New York.
Hardie, R.C. (1989) Neurotransmitters in compound eyes. In: Facets of vision. (Stavenga DG, Hardie, R.C. eds). pp. 235-256 Springer Berlin Heidelberg New York.
Hardie, R.C., Vogt, K., Rudolph, A. (1989) The compound eye of the Tse-tse fly, Glossina . J Insect Physiol 35:423-447.
v Hateren J.H., Hardie, R.C., Rudolph A., Laughlin S.B., Stavenga D.G. (1988) The bright zone: the dorsal eye of the male blowfly Chrysomia megalocephala. J Comp Physiol A 164:297-308
Hardie, R.C. (1988) Effects of antagonists on putative histamine receptors in the first visual neuropile of the housefly (Musca domestica) J Exp Biol 138,221-241
Nässel, D.R., Homlqvist, M.H., Hardie, R.C., Hakanson ,R., & Sundler, F. (1988) Histamine-like immunoreactivity in photoreceptors of the compound eyes and ocelli of flies. Cell Tissue Res 253:638- 646. ref
Simmons P.J., Hardie, R.C. (1988) Evidence that histamine is a neurotransmitter of photoreceptors of the locust ocellus J. Exp Biol 138,205-219
Hardie, R.C. (1988) The eye of the mantid shrimp. News & Views. Nature 333, 499-500
Kirschfeld K., Hardie, R.C., Lenz. G., Vogt, K. (1988) The pigment system of the photoreceptor 7 yellow in the fly, a complex photoreceptor. J Comp Physiol A 162:421-433
Hardie, R.C. (1987) Is histamine a neurotransmitter in insect photoreceptors? J Comp Physiol A 161:201-213 ref
Hardie R.C (1986b) The bee's celestial compass. News and Views Nature 323, 106-107
Hardie R.C. (1986a) The photoreceptor array of the dipteran retina Trends in Neurosci. 99, 419-423
Hardie R.C. (1985) Functional organization of the fly retina In: Ottoson D (ed.) Progress in Sens Physiol vol. 5 Springer, Berlin, Heidelberg, New York, Toronto pp 1-79
Hardie R.C. (1984) Properties of photoreceptors R7 and R8 in dorsal marginal ommatidia in the compound eyes of Musca and Calliphora. J Comp Physiol A 154:157-165
Kirschfeld K, Feiler R, Hardie R, Vogt K, Franceschini N (1983) The sensitizing pigment in fly photoreceptors. Properties and candidates Biophys Struct Mech 10: 81-92
Hardie R.C., Kirschfeld K (1983) Ultraviolet sensitivity of fly photoreceptors R7 and R8: evidence for a sensitising function Biophys Struct Mech 9:171-180
Hardie R.C. (1983) Projection and connectivity of sex-specific photoreceptors in the compound eye of the male housefly Musca domestica Cell Tissue Res 233:1-21
Blest A.D. Hardie R.C. McIntyre P. Williams D.S. (1981) The spectral sensitivities of identified receptors and the function of retinal tiering in the principal eyes of a jumping spider. J Comp Physiol A 145 227- 239
Franceschini N, Hardie R.C., Ribi W, Kirschfeld K (1981) Sexual dimorphism in a photoreceptor Nature 291: 241-244
Hardie R.C., Franceschini N, Ribi W, Kirschfeld K (1981) Distribution and properties of sex-specific photoreceptors in the fly Musca domestica. J Comp Physiol A 145:139-152
Hardie R.C., Franceschini N, McIntyre PD (1979) Electrophysiological analysis of the fly retina II Spectral and polarization sensitivity in R7 and R8 J Comp Physiol A 133:23-39
Hardie R.C. (1979) Electrophysiological analysis of the fly retina I Comparative properties of R1-6 and R7 and R8 J Comp Physiol A 129:19-33
Laughlin SB, Hardie R.C. (1978) Common strategies for light adaptation in the peripheral visual systems of fly and dragonfly J Comp Physiol A 128:319-340
Hardie R.C. Duelli P (1978) Properties of single cells in posterior lateral eyes of jumping spiders. Z Naturforsch 33c 156-158
Hardie R.C. (1978) Peripheral visual function in the fly. PhD Thesis ANU Canberra Australia
Hardie R.C. (1977) Electrophysiological properties of R7 and R8 in dipteran retina. Z Naturforsch 32c:887- 889
Horridge G.A, Mimura K, Hardie R.C. (1976) Fly photoreceptors III. Angular sensitivity as a function of wavelength and the limits of resolution. Proc R. Soc. Lond. B 194:151-177
Books/Volumes
The physiology of the compound eyes of insects and crustaceans. Sigmund Exner. Translated and annotated by R.C. Hardie (1988) Springer Heidelberg Berlin New York Tokyo.
Facets of vision: compound eyes from Exner to Autrum and beyond. (1989) Eds. Stavenga, D.G. & Hardie R.C. Springer Heidelberg Berlin New York Tokyo.
Lipids in Ca2+ Signalling. Cell Calcium Special Issue Vol 45 Issue 6 p 517-650 (June 2009) Edited by R.C. Hardie and S Muallem