Roger Hardie FRS
Roger C Hardie publications (with Pubmed/Journal links)
Articles
Chu B, Postma M, Hardie RC (2013) Fractional
Ca(2+) Currents through TRP and TRPL Channels in Drosophila Photoreceptors.
Biophys J 104:1905-1916 ref
Sengupta
S, Barber TR, Xia H, Ready DF, Hardie RC (2013) Depletion of PtdIns(4,5)P2
underlies retinal degeneration in Drosophila trp mutants. J Cell Sci
126:1247-1259 ref
Chu
B, Liu CH, Sengupta S, Gupta A, Raghu P, Hardie RC (2013) Common mechanisms
regulating dark noise and quantum bump amplification in Drosophila
photoreceptors. J Neurophysiol 109:2044-2055 ref
Wardill
TJ, List O, Li X, Dongre S, McCulloch M, Ting CY, O'Kane CJ, Tang S, Lee CH,
Hardie RC, Juusola M (2012) Multiple spectral inputs improve motion
discrimination in the Drosophila visual system. Science 336:925-931 ref
Satoh, A., Xia, H., Yan, L Hardie, R.C., Ready, DF. (2010) Arrestin
translocation is stoichiometric to rhodopsin isomerization and accelerated by
phototransduction in Drosophila photoreceptors Neuron 67, 997-1008 ref
Fain, G; Hardie, R.C., Laughlin, S.B. (2010) Phototransduction and the
evolution of photoreceptors. Curr. Biol., 20, R114-124 ref
Mecklenburg, K.L., Takemori, N., Komori, N., Chu, B., Hardie, R.C.,
Matsumoto, H., and O'Tousa, J.E. (2010) Retinophilin Is a Light-Regulated
Phosphoprotein Required to Suppress Photoreceptor Dark Noise in Drosophila. J.
Neurosci. 30, 1238-1249.ref
Huang, J, Liu, C-H, Hughes, S.A, Postma, M, Schwiening, C Hardie.R.C.
Activation of TRP channels by protons and phosphoinositide depletion and in Drosophila
photoreceptors. (2010) Cur Biol 20,189-197 ref
Yau, K-W, Hardie, R.C (2009) Phototransduction Motifs in Vertebrates and
Invertebrates Cell 139,246-264 ref
Hardie, R.C., Muallem, S Lipids in Ca2+ signalling - An
Introduction. (2009) Cell Calcium 45,517-520 ref
Raghu, P., Hardie, R.C. Regulation of Drosophila TRPC channels by
lipid messengers. (2009) Cell Calcium 45, 566-573 ref
Yusein,S., Velikova, N., Kupenova,P.,Hardie,R., Wolstenholme A and
Semenov, E (2008) Altered ivermectin pharmacology and defective visual system
in Drosophila mutants for histamine receptor HCLB. Invert Neurosc
8,211-222
Liu, C.-H., Satoh, A.K., Postma, M., Huang, J., Ready, D.F., and Hardie,
R.C. (2008.). Ca2+ dependent metarhodopsin inactivation mediated by
calmodulin and NINAC myosin III. Neuron 59 778-789 ref
Krause, S., Krause, Y., Liu, C.-H., Huang, J., Hardie, R.C., and Weckstrom,
M. (2008). Light-dependent modulation of Shab channels via
phosphoinositide depletion in Drosophila photoreceptors. Neuron
59, 596-607. ref
Pantazis, A., Segaran, A., Liu, C.H., Nikolaev, A., Rister, J., Thum, A.,
Semenov, E., Juusola, M., and Hardie, R.C. (2008). Distinct roles for two
histamine receptors (hclA and hclB) at the Drosophila
photoreceptor synapse. J Neurosci. 28:7250-7259 ref
Hardie, R.C. (2007). Vision: dynamic platforms. Nature 450, 37-39.
Hardie, R.C., and Postma, M. (2007). Phototransduction in microvillar
photoreceptors of Drosophila and other invertebrates. In The Senses - a
comprehensive reference Vision Volume 1 (eds. Albright, Masland)
pp. 77-130, K. Basbaum, Shepher, Westheimer., ed. (Oxford: Academic Press).
Liu, C-H, Wang, T, Postma, M, Obukhov, AG, Montell, C & Hardie, RC
(2007). In vivo identification and manipulation of the Ca2+
selectivity filter in the Drosophila TRP channel. J. Neurosci. 27
604-615 ref
Hardie, RC (2006). TRP channels and lipids: from Drosophila to
mammalian physiology. J Physiol Lond. 578 9-25 ref
Hardie, R.C. Phototransduction in Invertebrate Photoreceptors (2006) In:
Invertebrate Vision eds Warrant E, Nillson, D-E. C.U.P. pp.43-80
M. Vähäsöyrinki, J. E. Niven, R. C. Hardie, M. Weckström & M. Juusola
Robustness of Neural Coding in Drosophila Photoreceptors in the Absence of Slow
Delayed Rectifier K+ Channels. (2006) J Neurosci. 26:2652-2660 ref
Zheng, L.,Polaveja, G.G, Wolfram, V., Asyali, M.H., Hardie, R.C. &
Juusola, M. (2006) Adaptation and feedback regulation in the first visual
synapse of in vivo Drosophila. J. Gen Physiol. 127, 495-510ref
Rosenbaum E, Hardie RC and Colley NJ Calnexin is Essential for Rhodopsin
Maturation, Calcium Homeostasis and Photoreceptor Cell Survival (2006). Neuron
49 229-241 ref
Hardie R.C. (2005) Inhibition of phospholipase C activity in
Drosophila photoreceptors by BAPTA and di-bromo-BAPTA. Cell Calcium 38,547-556 ref
Gu, Y, Oberwinkler, J, Postma, M., Hardie, R.C. (2005) Mechanisms of light
adaptation in Drosophila photoreceptors. Current Biology
15,1228-1234 ref
Georgiev P, Garcia-Murillas I, Ulahannan D, Hardie RC and Raghu P (2005)
Functional INAD complexes are required to mediate degeneration in photoreceptors
of the Drosophila rdgA mutant. J Cell Science 118; 1373-1384 ref
MacPherson, M.R., Pollock, V.P, Kean, L, Southall T.D., Giannakou,M.E.,
Broderick,K.E,, Dow,J.A.T.,. Hardie, R.C and Davies,S.A. (2005) Transient
receptor potential-like (TRPL) channels are essential for calcium signalling
and fluid transport in a Drosophila epithelium. Genetics 169:1541-1552 ref
Wang,T., Xu H, Oberwinkler, J, Gu, Y,Hardie, R.C. (2005)
and Montell, C. Light-Activation, Adaptation and Cell Survival Functions
of the Na+/Ca2+ Exchanger, CalX. Neuron 45:367-378 ref
Hardie, RC, Gu, Y Martin, F., Sweeney, S., Raghu P (2004) In vivo light
induced and basal phospholipase C measured with genetically targeted PIP2 sensitive
ion channels (Kir.21). J Biol Chem 279, 47773-47782. erf
Hardie, R.C. (2004) Regulation of Drosophila TRP channels by lipid
messengers. In: Mammalian TRP channels as molecular targets. (Novartis
Foundation Symposium). pp. 160-171 Wiley Chichester
Niven, J.E., M. Vahasoyrinki, M. Kauranen, R.C. Hardie, M. Juusola, and M.
Weckstrom. (2003). The contribution of Shaker K+ channels to the
information capacity of Drosophila photoreceptors. Nature. 421:630-4. ref
Hardie, R.C., F. Martin, S. Chyb, and P. Raghu. (2003). Rescue of Light
Responses in the Drosophila "Null" Phospholipase C Mutant, norpAP24,
by the Diacylglycerol Kinase Mutant, rdgA, and by Metabolic Inhibition. J.
Biol. Chem. 278:18851-18858. ref
Hardie, R.C. (2003). TRP channels in Drosophila photoreceptors: the
lipid connection. Cell Calcium. 33:385-393. ref
Hardie, R.C. (2003). Regulation of TRP channels via lipid second messengers.
Annu Rev Physiol. 65:735-59. ref
Hardie, R.C. (2003). Phototransduction: shedding light on translocation. Curr
Biol. 13:R775-7.
Hardie, R.C. et al (2002) Molecular basis of amplification in Drosophila
phototransduction: roles for G protein, phospholipase C and
diacylglycerol kinase. Neuron, 36,689-701 ref
Geng, C. Leung H-T, Skingsley DR, Iovchev, MI
ZhanYin, Semenov EP, Burg MG, Hardie RC, Pak WL. (2002) Target
of Drosophila Photoreceptor Synaptic Transmission is Histamine-Gated
Chloride Channel Encoded by ort (hclA). J. Biol Chem 277,42113-42120 ref
Hardie R.C. (2002) Adaptation through translocation. Neuron (preview) 34,
3-5.
Hardie R.C. (2001) Phototransduction in Drosophila. J. Exp . Biol.
204:3403-3409 ref
Hardie, R.C. & Raghu, P. (2001) Visual transduction in Drosophila.
Nature 41:186-193 ref
Polyanovsky, A., Zierold, K., Hardie, R.C. Gribakin, F.. Electrolyte distribution
in Drosophila ommatidium as revealed by electron probe X-ray
microanalysis. In prep.
Hardie, R.C., Raghu, P. , Moore, S. Juusola, M. Baines R.A & Sean T.
Sweeney (2001) Calcium influx via TRP channels is required to maintain PIP2
levels in Drosophila photoreceptors. Neuron 30 149-159 ref
Juusola M, Hardie RC (2001) Light-Adaptation in Drosophila
Photoreceptors: II Rising temperature increases the bandwidth of reliable
signalling J Gen Physiol. 2000 117: 27-42. ref
Juusola M, Hardie RC (2001) Light-Adaptation in Drosophila
Photoreceptors: I. Response dynamics and signaling efficiency at 25oC
J Gen Physiol. 2000 117: 3-25. ref
Raghu,P , Colley N, Hasan, G, Selinger Z, &. Hardie RC (2000)
Normal phototransduction in Drosophila photoreceptors lacking an InsP3
receptor gene. Mol. Cell Neurosci. 15: 429-445. ref
Raghu, P. Usher, K., Jonas, S.,Chyb, S, Polyanovsky, A, Hardie RC (2000).
Constitutive activity of the light-sensitive channels TRP and TRPL in
Drosophila diacylglycerol kinase mutant, retinal degeneration A (rdgA).
Neuron 26:169-179 ref
Henderson, SR, Reuss H, Hardie RC (2000) Single photon responses in Drosophila
photoreceptors and their regulation by Ca2+. J.
Physiol. 524, 179-194 ref
Minke B, Hardie R.C Genetic dissection of phototransduction in Drosophila.
(2000) Handbook of Biological Physics, Vol 3: Primary Visual
Processes (D.G Stavenga, W.J. de Grip, Pugh EJ Jr. eds.). Elsevier (pp
449-525).
Polyanovskii, A.D., Hardie, R.C. & Krause, K.H. The TRP protein in
Drosophila photoreceptors: An immunogold localization of the light-sensitive
calcium-permeable channel. J Evol Biochem Physiol 35, 669-680 (1999).
Chyb,S, Hevers W, Forte M, Wolfgang WJ, Selinger Z,
Hardie, RC (1999) Modulation of the light response by cAMP in Drosophila
photoreceptors. J . Neurosci. 1999 19: 8799-8807 ref
Chyb S, Raghu, P., Hardie.R.C. (1999) Poly-unsaturated fatty acids activate
the Drosophila light-sensitive channels TRP and TRPL. Nature 397:255-259
ref
Hardie, R.C., Raghu, P (1998) Activation of heterologously expressed Drosophila
TRPL channels: Ca2+ is not required, InsP3 is not
sufficient. Cell Calcium 24:153-163. ref
Yagodin, S., Hardie, R.C, Millar, N, Mason, W., & Sattelle DB
(1998). Thapsigargin and receptor-mediated activation of Drosophila
TRPL channels expressed in a Drosophila S2 cell line Cell Calcium
23:219
Reuss H., Mojet, M., Chyb, S. & Hardie R.C (1997) In vivo analysis of
the Drosophila light-sensitive channels TRP and TRPL Neuron 19: 1249-1259
ref
Hardie R.C., Reuss H., Lansdell, S.J. & Millar, N.S. (1997)
Functional equivalence of native light-sensitive channels in the Drosophila
trp301 mutant and TRPL cation channels expressed in a stable
cell line. Cell Calcium. 21: 431-440. ref
Hardie RC (1997b) Excitation in Drosophila photoreceptors. . Cloe
Taddei-Ferretti and Carlo Musio, eds.,"From Structure to Information in
Sensory Systems", World Scientific, Singapore, New Jersey, London, Hong
Kong, 1997.
Hardie RC (1997a) Properties of light-sensitive channels in Drosophila
photoreceptors. Cloe Taddei-Ferretti and Carlo Musio, eds.,"From Structure
to Information in Sensory Systems", World Scientific, Singapore, New
Jersey, London, Hong Kong, 1997.
Hardie R.C. (1996) Setting store by Calcium. Current Biology. 6: 1371-1373.
Hofstee, CA, Henderson S, Hardie RC, Stavenga DG (1996) Differential effects
of calmodulin binding proteins (p132 and p174) on pigment migration and
light-activated currents in Drosophila photoreceptors. Visual Neurosci.
13:987-906. ref
Hardie RC (1996c) Excitation of Drosophila photoreceptors by BAPTA
and ionomycin: evidence for capacitative Ca2+ entry? Cell Calcium
20:315-327. ref
Hardie RC (1996b) A quantitative estimate of the maximum amount of
light-induced Ca2+ release in Drosophila photoreceptors. J
Photochem Photobiol. 35; 83-89. ref
Hardie RC (1996a) INDO-1 measurements of resting and light-induced cytosolic
Ca in Drosophila photoreceptors. J Neurosci. 16:2924-2933 ref
Anderson J, Hardie RC (1996). Different photoreceptors in the same retina
contain unique complements of K channels. J Comp Physiol. 178,513-422
Hardie RC, Minke B (1995) Phosphoinositide-mediated phototransduction in fly
photoreceptors: the role of Ca2+ and TRP. Cell Calcium 16:256-274 ref
Hardie RC, Mojet MH (1995) Magnesium dependent block of the light-activated-
and trp-dependent conductance in Drosophila photoreceptors. (J
Neurophysiol.74:2590-2599)
Hardie RC (1995b) Effects of intracellular Ca2+ chelation
on the light response in Drosophila photoreceptors. J Comp Physiol
A 177: 707-721. ref
Pollock JA, Assaf A, Peretz A, Nichols CD, Mojet MH, Hardie RC, Minke B
(1995) TRP a protein essential for inositide-mediated Ca2+
influx is localized adjacent to the calcium stores in Drosophila
photoreceptors. J Neurosci. 15:3747-3760.
Skingsley DR, Laughlin SB, Hardie RC (1995) Properties of
histamine-activated chloride channels in the large monopolar cells (LMCs) of
the dipteran compound eye: a comparative study. J comp Physiol
176:611-623
Hevers W, Hardie RC (1995) Serotonin modulates the voltage dependence
of Shaker potassium channels in Drosophila photoreceptors Neuron
14: 845-856 ref
Cuttle M, Hevers W, Laughlin, SB, Hardie RC (1995) Diurnal modulation
of potassium conductance in locust photoreceptors. J comp Physiol A 176:307-316
Hardie, R.C. (1995a) Caged Ca2+ facilitates and inactivates
but does not directly excite light sensitive channels in Drosophila
photoreceptors. J Neurosci. 15:889-902 ref
Peretz, A., Sandler, C., Kirschfeld, K.,Hardie R.C., and Minke, B. (1994)
Genetic dissection of light-induced Ca2+ influx into Drosophila
photoreceptors. J. gen. Physiol. 104:1-57-1078 ref
Hardie, R.C., and Minke, B (1994) Ca2+-dependent inactivation of light-sensitive
channels in Drosophila photoreceptors. J. gen. Physiol.103:409-427 ref
Hardie, R.C., and Minke, B (1994) Spontaneous activation of light-sensitive
channels in Drosophila photoreceptors. J. gen. Physiol.103:389-407
Hardie , R.C. (1993) Phototransduction: the invertebrate enigma. News &
Views Nature 366:113-114
Hardie, R.C., and Minke, B (1993) Novel Ca2+ channels underlying
transduction in Drosophila photoreceptors: implications for
phosphoinositide-mediated Ca2+ mobilization. Trends Neurosci.
16:371-376. ref
Hardie, R.C. & Minke, B. (1993) Phototransduction in Drosophila.
In: Sensory systems of arthropods (Wiese K, Gribakin FG, Popov AV &
Renninger G eds) pp. 3-12 Birkhauser Verlag Basel Boston Berlin
Hardie, R.C., Suss-Toby, E., Peretz, A., Rom-Glas, A., Selinger, Z. &
Minke, B (1993) Protein kinase C is required for light adaptation in Drosophila
photoreceptors. Nature 363, 634-637. ref
Hardie R.C., Pollock J.A, Peretz, A. & Minke B (1993) Ca2+ limits
the development of the light response in Drosophila
photoreceptors. Proc Roy Soc Lond B 252:223-229. ref
Hardie, R.C. Minke, B. (1992) Light-activated channels in Drosophila
are coded by the trp gene. In: Structures and functions of retinal
proteins. Ed. J.L Rigaud. Colloque INSERM/ John Libbey Eurotext Ltd Vol
221:403-406.
Hardie RC, Minke B. (1992) The trp gene is essential for a
light-activated Ca channel in Drosophila photoreceptors. Neuron
8,643-651. ref
Hardie RC (1991b) Voltage sensitive potassium channels in Drosophila
photoreceptors. J. Neurosci. 11:3079- 3095 ref
Hardie RC (1991a) Whole-cell recordings of the light-induced current in Drosophila
photoreceptors: evidence for feedback by calcium permeating the light sensitive
channels. Proc Roy Soc Lond B. 245:203-210
Weckström M, Hardie, RC & Laughlin SB (1991). Voltage-activated
potassium channels in blowfly photoreceptors and their role in
light-adaptation. J. Physiol. Lond 440:635-657 ref
Hardie, RC, Voss D, Pongs O & Laughlin SB (1991) Novel potassium
channels encoded by the Shaker locus in Drosophila
photoreceptors. Neuron 6:477-486 ref
Hardie R.C & Weckström, M. (1990) Three classes of potassium channels in
identified non-spiking visual interneurones from the blowfly Calliphora
vicina. J. comp. Physiol. 167: 723-736
Hardie, R.C. (1989) A histamine-gated chloride channel involved in synaptic
transmission at a photoreceptor synapse. Nature,339:704-706 ref
Hardie, R.C., Laughlin, S.B., Osorio, D-C. (1989). Early visual processing
in the compound eye: physiology and pharmacology of the retina-lamina
projection in the fly. In: Neurobiology of sensory systems. Singh N, Strausfeld
NJ eds. pp. 23-42 Plenum New York.
Hardie, R.C. (1989) Neurotransmitters in compound eyes. In: Facets of
vision. (Stavenga DG, Hardie, R.C. eds). pp. 235-256 Springer Berlin Heidelberg
New York.
Hardie, R.C., Vogt, K., Rudolph, A. (1989) The compound eye of the Tse-tse
fly, Glossina . J Insect Physiol 35:423-447.
v Hateren J.H., Hardie, R.C., Rudolph A., Laughlin S.B., Stavenga D.G.
(1988) The bright zone: the dorsal eye of the male blowfly Chrysomia
megalocephala. J Comp Physiol A 164:297-308
Hardie, R.C. (1988) Effects of antagonists on putative histamine receptors
in the first visual neuropile of the housefly (Musca domestica) J Exp
Biol 138,221-241
Nässel, D.R., Homlqvist, M.H., Hardie, R.C., Hakanson ,R., & Sundler, F.
(1988) Histamine-like immunoreactivity in photoreceptors of the compound eyes
and ocelli of flies. Cell Tissue Res 253:638- 646. ref
Simmons P.J., Hardie, R.C. (1988) Evidence that histamine is a
neurotransmitter of photoreceptors of the locust ocellus J. Exp Biol
138,205-219
Hardie, R.C. (1988) The eye of the mantid shrimp. News & Views. Nature
333, 499-500
Kirschfeld K., Hardie, R.C., Lenz. G., Vogt, K. (1988) The pigment system of
the photoreceptor 7 yellow in the fly, a complex photoreceptor. J Comp
Physiol A 162:421-433
Hardie, R.C. (1987) Is histamine a neurotransmitter in insect
photoreceptors? J Comp Physiol A 161:201-213 ref
Hardie R.C (1986b) The bee's celestial compass. News and Views Nature 323,
106-107
Hardie R.C. (1986a) The photoreceptor array of the dipteran retina Trends in
Neurosci. 99, 419-423
Hardie R.C. (1985) Functional organization of the fly retina In: Ottoson D
(ed.) Progress in Sens Physiol vol. 5 Springer, Berlin, Heidelberg, New York,
Toronto pp 1-79
Hardie R.C. (1984) Properties of photoreceptors R7 and R8 in dorsal marginal
ommatidia in the compound eyes of Musca and Calliphora. J Comp
Physiol A 154:157-165
Kirschfeld K, Feiler R, Hardie R, Vogt K, Franceschini N (1983) The
sensitizing pigment in fly photoreceptors. Properties and candidates Biophys
Struct Mech 10: 81-92
Hardie R.C., Kirschfeld K (1983) Ultraviolet sensitivity of fly
photoreceptors R7 and R8: evidence for a sensitising function Biophys Struct
Mech 9:171-180
Hardie R.C. (1983) Projection and connectivity of sex-specific
photoreceptors in the compound eye of the male housefly Musca domestica
Cell Tissue Res 233:1-21
Blest A.D. Hardie R.C. McIntyre P. Williams D.S. (1981) The spectral sensitivities
of identified receptors and the function of retinal tiering in the principal
eyes of a jumping spider. J Comp Physiol A 145 227- 239
Franceschini N, Hardie R.C., Ribi W, Kirschfeld K (1981) Sexual dimorphism
in a photoreceptor Nature 291: 241-244
Hardie R.C., Franceschini N, Ribi W, Kirschfeld K (1981) Distribution and
properties of sex-specific photoreceptors in the fly Musca domestica. J
Comp Physiol A 145:139-152
Hardie R.C., Franceschini N, McIntyre PD (1979) Electrophysiological analysis
of the fly retina II Spectral and polarization sensitivity in R7 and R8 J Comp
Physiol A 133:23-39
Hardie R.C. (1979) Electrophysiological analysis of the fly retina I
Comparative properties of R1-6 and R7 and R8 J Comp Physiol A 129:19-33
Laughlin SB, Hardie R.C. (1978) Common strategies for light adaptation in
the peripheral visual systems of fly and dragonfly J Comp Physiol A 128:319-340
Hardie R.C. Duelli P (1978) Properties of single cells in posterior lateral
eyes of jumping spiders. Z Naturforsch 33c 156-158
Hardie R.C. (1978) Peripheral visual function in the fly. PhD Thesis ANU
Canberra Australia
Hardie R.C. (1977) Electrophysiological properties of R7 and R8 in dipteran
retina. Z Naturforsch 32c:887- 889
Horridge G.A, Mimura K, Hardie R.C. (1976) Fly photoreceptors III. Angular
sensitivity as a function of wavelength and the limits of resolution. Proc R.
Soc. Lond. B 194:151-177
Books/Volumes
The physiology of the compound eyes of insects and crustaceans. Sigmund
Exner. Translated and annotated by R.C. Hardie (1988) Springer Heidelberg
Berlin New York Tokyo.
Facets of vision: compound eyes from Exner to Autrum and beyond. (1989) Eds.
Stavenga, D.G. & Hardie R.C. Springer Heidelberg Berlin New York Tokyo.
Lipids in Ca2+ Signalling. Cell Calcium Special Issue Vol 45
Issue 6 p 517-650 (June 2009) Edited by R.C. Hardie and S Muallem