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Professor Roger C Thomas FRS

Microelectrode investigation of ionic homeostasis in voltage-clamped snail neurones.
Professor Roger C Thomas, FRS

Emeritus Professor of Physiology


Office Phone: +44 (0) 1223 333869, Fax: +44 (0) 1223 333840

Research Interests

My research focuses on exploring the interactions between the proton channels and calcium pumps in the cell membrane of snail neurones, using ion-sensitive fluorescent indicators and microelectrodes.

Collaborators

Dr Christof Schwiening

Teaching

Homeostasis lectures and practicals, 1B Physiology practicals, Part II Cell Physiology  module.

Key Publications

Thomas RC, (2013), Calcium content of the endoplasmic reticulum of snail neurones releasable by caffeine, Cell Calcium, 53, 120– 124

Thomas RC, (2011), The Ca(2+):H(+) coupling ratio of the plasma membrane calcium ATPase in neurones is little sensitive to changes in external or internal pH, Cell Calcium, 49(6):357-64

Thomas RC, (2009), The plasma membrane calcium ATPase (PMCA) of neurones is electroneutral and exchanges 2 H+ for each Ca2+ or Ba2+ ion extruded, J Physiol, 587.2 315–327

Thomas RC, Postma M, (2007), Dynamic and static calcium gradients inside large snail (Helix aspersa) neurones detected with calcium-sensitive microelectrodes, Cell Calcium, 41 365–378

Thomas RC, (2002), The effects of HCl and CaCl2 injections on intracellular calcium and pH in voltage-clamped snail (Helix aspersa) neurons, J gen Physiol, 120; 567-579

Kennedy HJ, Thomas RC, (1996), Effects of injecting calcium-buffer solutions on Ca[2+]i in voltage-clamped snail neurons, Biophys. J. 70, 2120-2130

Schwiening CJ, Kennedy HJ, Thomas RC, (1993), Calcium-hydrogen exchange by the plasma membrane Ca-ATPase of voltage-clamped snail neurons, Proc. R. Soc. Lond. B. 253, 285-289

Thomas RC, (1984), Review Lecture:  Experimental displacement of intracellular pH and the mechanism of its subsequent recovery, J Physiol, 354, 3P‑22P

Thomas RC, Meech RW, (1982), Hydrogen ion currents and intracellular pH in depolarized voltage‑clamped snail neurones, Nature, 299, 826‑828

Thomas RC, (1977), The role of bicarbonate, chloride and sodium ions in the regulation of intracellular pH in snail neurones,  J Physiol, 273, 317‑338

Thomas RC, (1976), Ionic mechanism of the H+ pump in a snail neurone, Nature, 262, 54‑55

Thomas RC, (1974), Intracellular pH of snail neurones measured with a new pH‑sensitive glass microelectrode, J Physiol, 238, 159‑180

 

Above: Snail sub-oesophageal ganglion preparation.