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Department of Physiology, Development and Neuroscience

 

Research

Phototransduction and olfactory transduction. Calcium homeostasis in vertebrate photoreceptors and olfactory receptors, and its role in modulating their electrical responses. Light-induced calcium release within the photoreceptor outer segment.

Research students

Ms Salomé Antolin
Ms Yiu Tak Leung

Current collaborators

Prof Gordon L. Fain, Department of Physiological Science, University of California at Los Angeles, Los Angeles, CA, USA
Prof Carter Cornwall, Department of Physiology, Boston University Medical School, Boston, MA, USA
Prof Rosalie K Crouch, Department of Ophthalmology, Medical University of South Carolina, Charleston, SC, USA
Dr Alapakkam P Sampath, Department of Physiology & Biophysics, University of Washington, Seattle, WA, USA
Dr Johannes Reisert, Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, USA

Publications

Key publications: 

Antolin S, Reisert J, Matthews HR, (2010), Olfactory response termination involves Ca2+-ATPase in vertebrate olfactory receptor neuron cilia, J Gen Physiol, 135(4):367-78

Matthews HR, Sampath AP (2010), Photopigment quenching is Ca2+ dependent and controls response duration in salamander L-cone photoreceptors, J Gen Physiol, 135(4):355-66

Antolin S, Matthews HR (2007), The effect of external sodium concentration on sodium-calcium exchange in frog olfactory receptor cells, J Physiol, 581(Pt 2):495-503

Leung YT, Fain GL, Matthews HR (2007), Simultaneous measurement of current and calcium in the ultraviolet-sensitive cones of zebrafish, Journal of Physiology, 579:15-27

Matthews HR, Fain GL (2003), The effect of light on outer segment calcium in salamander rods, Journal of Physiology, 552:763-776

Fellow of St John's College
Picture of Dr Hugh  Matthews

Contact Details

+44 (0) 1223 333803, Fax: +44 (0) 1223 333840
Email address: